SE9902899D0 - New peptides, corresponding antibodies, and compositions thereof - Google Patents

New peptides, corresponding antibodies, and compositions thereof

Info

Publication number
SE9902899D0
SE9902899D0 SE9902899A SE9902899A SE9902899D0 SE 9902899 D0 SE9902899 D0 SE 9902899D0 SE 9902899 A SE9902899 A SE 9902899A SE 9902899 A SE9902899 A SE 9902899A SE 9902899 D0 SE9902899 D0 SE 9902899D0
Authority
SE
Sweden
Prior art keywords
sufuh
gli
peptides
pharmaceutical compositions
compositions
Prior art date
Application number
SE9902899A
Other languages
Swedish (sv)
Inventor
Rune Toftgaard
Priit Kogerman
Thomas Grimm
Lembi Kogerman
Darren Krause
Bengt Sandstedt
Anna Birgitte Unden
Peter G Zaphiropoulos
Original Assignee
Karolinska Innovations Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karolinska Innovations Ab filed Critical Karolinska Innovations Ab
Priority to SE9902899A priority Critical patent/SE9902899D0/en
Publication of SE9902899D0 publication Critical patent/SE9902899D0/en
Priority to AU67444/00A priority patent/AU6744400A/en
Priority to PCT/SE2000/001576 priority patent/WO2001012655A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to the field of mammalian signalling pathways, and more precisely to the physical interaction between two components of the Sonic hedgehog (Shh)-Patched (Ptch) signalling pathway, namely GLI-1 and SUFUH. The invention provides peptides consisting of fragments of GLI-1 and SUFUH, respectively which are able to specifically bind to SUFUH and GLI-1, respectively. The invention also provides monoclonal antibodies and antibody fragments specifically binding to these peptides, as well as pharmaceutical compositions containing the peptides, antibodies and/or antibody fragments, said pharmaceutical compositions being useful for treating cancer and diseases influencing cell differentiation and tissue development.
SE9902899A 1999-08-13 1999-08-13 New peptides, corresponding antibodies, and compositions thereof SE9902899D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE9902899A SE9902899D0 (en) 1999-08-13 1999-08-13 New peptides, corresponding antibodies, and compositions thereof
AU67444/00A AU6744400A (en) 1999-08-13 2000-08-14 Peptides consisting of fragments of gli-1 and sufuh and their use
PCT/SE2000/001576 WO2001012655A1 (en) 1999-08-13 2000-08-14 Peptides consisting of fragments of gli-1 and sufuh and their use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9902899A SE9902899D0 (en) 1999-08-13 1999-08-13 New peptides, corresponding antibodies, and compositions thereof

Publications (1)

Publication Number Publication Date
SE9902899D0 true SE9902899D0 (en) 1999-08-13

Family

ID=20416664

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9902899A SE9902899D0 (en) 1999-08-13 1999-08-13 New peptides, corresponding antibodies, and compositions thereof

Country Status (3)

Country Link
AU (1) AU6744400A (en)
SE (1) SE9902899D0 (en)
WO (1) WO2001012655A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE200200531A (en) * 2002-09-17 2004-04-15 O� InBio Production and use of therapeutic intracellular antibodies
US9248128B2 (en) 2012-01-27 2016-02-02 New York University Method for enhancing remyelination using GLI1 inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999032517A1 (en) * 1997-12-19 1999-07-01 Karolinska Innovations Ab Molecules associated with the human suppressor of fused gene

Also Published As

Publication number Publication date
WO2001012655A1 (en) 2001-02-22
AU6744400A (en) 2001-03-13

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