SE9801148D0 - New receptors - Google Patents
New receptorsInfo
- Publication number
- SE9801148D0 SE9801148D0 SE9801148A SE9801148A SE9801148D0 SE 9801148 D0 SE9801148 D0 SE 9801148D0 SE 9801148 A SE9801148 A SE 9801148A SE 9801148 A SE9801148 A SE 9801148A SE 9801148 D0 SE9801148 D0 SE 9801148D0
- Authority
- SE
- Sweden
- Prior art keywords
- vdrr
- polypeptides
- methods
- polypeptide
- novel
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 8
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 8
- 238000000034 method Methods 0.000 abstract 4
- 239000000126 substance Substances 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 108020005497 Nuclear hormone receptor Proteins 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000006255 nuclear receptors Human genes 0.000 abstract 1
- 108020004017 nuclear receptors Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 102000009310 vitamin D receptors Human genes 0.000 abstract 1
- 108050000156 vitamin D receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Abstract
The present invention relates to novel vitamin D receptor related (VDRR) polypeptides, and formulations containing the same. Nucleic acid sequences encoding the VDRR polypeptides, expression vectors containing such sequences and host cells transformed with such expression vectors are also disclosed, as are methods for the expression of the novel VDRR polypeptides of the invention. The invention further relates to VDRR polypeptides for use as medicaments, and use of substances affecting VDRR signal transduction for the manufacture of medicaments for treating metabolic, proliferative or inflammatory conditions. The present invention also relates to methods for identifying clones encoding a VDRR polypeptide, methods for identifying ligands to a VDRR and methods for identifying substances for treatment of conditions affected by a VDRR polypeptide. More specifically, the novel VDRR polypeptide can be the polypeptide designated VDRR gamma , which may be regulated by any small chemical molecule similar in structure to known ligands for nuclear receptors.
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9801148A SE9801148D0 (en) | 1997-10-14 | 1998-03-31 | New receptors |
JP2000515925A JP2001519441A (en) | 1997-10-14 | 1998-08-31 | Novel vitamin D receptor-related polypeptides, nucleic acid sequences encoding such polypeptides and uses thereof |
US09/143,828 US7118885B2 (en) | 1997-10-14 | 1998-08-31 | Nucleic acid encoding vitamin D receptor related polypeptide |
KR1020007004011A KR20010031120A (en) | 1997-10-14 | 1998-08-31 | Novel vitamin d receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof |
AU90131/98A AU732079B2 (en) | 1997-10-14 | 1998-08-31 | Novel vitamin D receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof |
CNB988112264A CN1134452C (en) | 1997-10-14 | 1998-08-31 | Vitamin D receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof |
EP98941985A EP1023323A1 (en) | 1997-10-14 | 1998-08-31 | Novel vitamin d receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof |
CA002306453A CA2306453A1 (en) | 1997-10-14 | 1998-08-31 | Novel vitamin d receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof |
NZ504025A NZ504025A (en) | 1997-10-14 | 1998-08-31 | Vitamin D receptor related polypeptides (VDRR) and its use in treating inflammatory disease |
PCT/SE1998/001548 WO1999019354A1 (en) | 1997-10-14 | 1998-08-31 | Novel vitamin d receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof |
US11/369,263 US20060228778A1 (en) | 1997-10-14 | 2006-03-06 | Novel vitamin D receptor related polypeptides, nucleic acid sequence encoding the same and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9703745A SE9703745D0 (en) | 1997-10-14 | 1997-10-14 | New receptors |
SE9801148A SE9801148D0 (en) | 1997-10-14 | 1998-03-31 | New receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9801148D0 true SE9801148D0 (en) | 1998-03-31 |
Family
ID=26663102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9801148A SE9801148D0 (en) | 1997-10-14 | 1998-03-31 | New receptors |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1023323A1 (en) |
JP (1) | JP2001519441A (en) |
KR (1) | KR20010031120A (en) |
CN (1) | CN1134452C (en) |
AU (1) | AU732079B2 (en) |
CA (1) | CA2306453A1 (en) |
NZ (1) | NZ504025A (en) |
SE (1) | SE9801148D0 (en) |
WO (1) | WO1999019354A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2315529A1 (en) * | 1997-12-12 | 1999-06-24 | Merck & Co., Inc. | Dna molecules encoding human nuclear receptor proteins, nnr7 and nnr7-1 |
US6756491B2 (en) * | 1998-01-09 | 2004-06-29 | The Salk Institute For Biological Studies | Steroid-activated nuclear receptors and uses therefor |
US6911537B2 (en) * | 1998-01-09 | 2005-06-28 | The Salk Institute For Biological Studies | Xenobiotic compound modulated expression systems and uses therefor |
US6984773B1 (en) | 1998-01-09 | 2006-01-10 | The Salk Institute For Biological Studies | Transgenic mice expressing a human SXR receptor polypeptide |
AU2003200641B2 (en) * | 1998-01-09 | 2008-04-03 | The Salk Institute For Biological Studies | Novel Steroid-activated Nuclear Receptors and Uses therefor |
JP2002535241A (en) * | 1998-03-27 | 2002-10-22 | グラクソ グループ リミテッド | Orphan nuclear receptor |
US7238491B1 (en) | 1998-03-27 | 2007-07-03 | Smithkline Beecham Corporation | Pregnane X receptor method |
FR2801311B1 (en) * | 1999-11-22 | 2005-08-26 | Centre Nat Rech Scient | POLYPEPTIDES DERIVED FROM THE NUCLEAR RECEPTOR OF VITAMIN D, AND USES THEREOF IN PARTICULAR IN THE SCREENING OF ANALOGUES OF VITAMIN D |
AU2006200258B2 (en) * | 1999-12-09 | 2009-04-09 | The Salk Institute For Biological Studies | Novel steroid-activated nuclear receptors and uses therefor |
US6514941B1 (en) | 1999-12-10 | 2003-02-04 | Campina Melkunie B.V. | Method of preparing a casein hydrolysate enriched in anti-hypertensive peptides |
US20040053866A1 (en) * | 2002-08-21 | 2004-03-18 | The Regents Of The University Of California | Tumor suppressor genes and their uses |
SE0400489D0 (en) * | 2004-02-27 | 2004-02-27 | Biovitrum Ab | Therapeutic proteins |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0407462A4 (en) * | 1988-03-30 | 1992-02-05 | Arch Development Corporation | Dna binding proteins including androgen receptor |
DE69232537T2 (en) * | 1991-09-17 | 2002-10-24 | Salk Inst For Biolog Studies L | RECEPTORS OF THE STEROID / THYROID SUPERFAMILY OF RECEPTORS |
US5756448A (en) * | 1992-02-26 | 1998-05-26 | The General Hospital Corporation | Constitute activator of retinoid (CAR) receptor polypeptides |
US6391847B1 (en) * | 1995-01-17 | 2002-05-21 | The Salk Institute For Biological Studies | Method, polypeptides, nucleotide sequence of XOR-6, a vitamin D-like receptor from xenopus |
WO1996036230A1 (en) * | 1995-05-16 | 1996-11-21 | The Salk Institute For Biological Studies | Modulators for new members of the steroid/thyroid superfamily of receptors |
-
1998
- 1998-03-31 SE SE9801148A patent/SE9801148D0/en unknown
- 1998-08-31 WO PCT/SE1998/001548 patent/WO1999019354A1/en not_active Application Discontinuation
- 1998-08-31 CN CNB988112264A patent/CN1134452C/en not_active Expired - Fee Related
- 1998-08-31 JP JP2000515925A patent/JP2001519441A/en active Pending
- 1998-08-31 EP EP98941985A patent/EP1023323A1/en not_active Withdrawn
- 1998-08-31 CA CA002306453A patent/CA2306453A1/en not_active Abandoned
- 1998-08-31 NZ NZ504025A patent/NZ504025A/en unknown
- 1998-08-31 KR KR1020007004011A patent/KR20010031120A/en not_active Application Discontinuation
- 1998-08-31 AU AU90131/98A patent/AU732079B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
KR20010031120A (en) | 2001-04-16 |
CN1134452C (en) | 2004-01-14 |
WO1999019354A9 (en) | 1999-12-02 |
NZ504025A (en) | 2003-04-29 |
CA2306453A1 (en) | 1999-04-22 |
AU732079B2 (en) | 2001-04-12 |
CN1279689A (en) | 2001-01-10 |
EP1023323A1 (en) | 2000-08-02 |
WO1999019354A1 (en) | 1999-04-22 |
JP2001519441A (en) | 2001-10-23 |
AU9013198A (en) | 1999-05-03 |
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