SE9702188D0 - Improved method for site-selective glycosylation - Google Patents
Improved method for site-selective glycosylationInfo
- Publication number
- SE9702188D0 SE9702188D0 SE9702188A SE9702188A SE9702188D0 SE 9702188 D0 SE9702188 D0 SE 9702188D0 SE 9702188 A SE9702188 A SE 9702188A SE 9702188 A SE9702188 A SE 9702188A SE 9702188 D0 SE9702188 D0 SE 9702188D0
- Authority
- SE
- Sweden
- Prior art keywords
- site
- improved method
- selective glycosylation
- polypeptide
- protein
- Prior art date
Links
- 230000013595 glycosylation Effects 0.000 title abstract 2
- 238000006206 glycosylation reaction Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 150000001720 carbohydrates Chemical group 0.000 abstract 2
- BLCJBICVQSYOIF-UHFFFAOYSA-N 2,2-diaminobutanoic acid Chemical group CCC(N)(N)C(O)=O BLCJBICVQSYOIF-UHFFFAOYSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 229960003104 ornithine Drugs 0.000 abstract 1
- -1 p-nitrophenyl ester Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The present invention is related to an improved method for site-selective glycosylation of folded polypeptides and proteins comprising an imidazole function, preferably histidine, in position i flanked by at least one functional group, such as lysine, ornithine and/or a diaminobutyric acid residue, in positions i+4 and/or i-3, according to which a carbohydrate residue is incorporated into the polypeptide or protein by reacting a p-nitrophenyl ester of a non-protected carbohydrate with the polypeptide or the protein.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9702188A SE9702188D0 (en) | 1997-06-06 | 1997-06-06 | Improved method for site-selective glycosylation |
PCT/SE1998/001008 WO1998055501A1 (en) | 1997-06-06 | 1998-05-28 | Improved method for site-selective glycosylation |
AU80444/98A AU8044498A (en) | 1997-06-06 | 1998-05-28 | Improved method for site-selective glycosylation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9702188A SE9702188D0 (en) | 1997-06-06 | 1997-06-06 | Improved method for site-selective glycosylation |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9702188D0 true SE9702188D0 (en) | 1997-06-06 |
Family
ID=20407299
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9702188A SE9702188D0 (en) | 1997-06-06 | 1997-06-06 | Improved method for site-selective glycosylation |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU8044498A (en) |
SE (1) | SE9702188D0 (en) |
WO (1) | WO1998055501A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0001698D0 (en) * | 2000-05-05 | 2000-05-05 | A & Science Invest Ab | Site-selective acyl transfer |
SE0202473D0 (en) | 2001-11-21 | 2002-08-19 | A & Science Ab | Site selective acylation |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9603323D0 (en) * | 1996-05-14 | 1996-09-12 | Ahlberg | Catalytic method and structure |
-
1997
- 1997-06-06 SE SE9702188A patent/SE9702188D0/en unknown
-
1998
- 1998-05-28 AU AU80444/98A patent/AU8044498A/en not_active Abandoned
- 1998-05-28 WO PCT/SE1998/001008 patent/WO1998055501A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO1998055501A1 (en) | 1998-12-10 |
WO1998055501A9 (en) | 1999-07-15 |
AU8044498A (en) | 1998-12-21 |
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