SE9401079L - New derivatives of aspartic acid and glutamic acid protected on the side chain carboxylic acid group form of esters which impede aspartimide formation in solid phase synthesis of peptides - Google Patents

New derivatives of aspartic acid and glutamic acid protected on the side chain carboxylic acid group form of esters which impede aspartimide formation in solid phase synthesis of peptides

Info

Publication number
SE9401079L
SE9401079L SE9401079A SE9401079A SE9401079L SE 9401079 L SE9401079 L SE 9401079L SE 9401079 A SE9401079 A SE 9401079A SE 9401079 A SE9401079 A SE 9401079A SE 9401079 L SE9401079 L SE 9401079L
Authority
SE
Sweden
Prior art keywords
side chain
peptides
impede
esters
solid phase
Prior art date
Application number
SE9401079A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE9401079D0 (en
Inventor
Anders Unden
Original Assignee
Anders Unden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anders Unden filed Critical Anders Unden
Priority to SE9401079A priority Critical patent/SE9401079L/en
Publication of SE9401079D0 publication Critical patent/SE9401079D0/en
Priority to PCT/SE1995/000337 priority patent/WO1995026975A1/en
Publication of SE9401079L publication Critical patent/SE9401079L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A protective group bound to a side chain of an amino-acid moiety, which group is an aliphatic acyclic branched alkyl group protecting a thiol, hydroxyl, or carboxyl group or an aliphatic acyclic branched alkoxycarbonyl group protecting an amino group or heterocyclic nitrogen, wherein the alkyl and alkoxy entities have from 6 to 18 carbon atoms and have at least two identical alkyl chains, is described. Further, the use of such a protective group bound to a side chain of an amino-acid moiety in the synthesis of peptides, polypeptides and proteins is disclosed.
SE9401079A 1994-03-30 1994-03-30 New derivatives of aspartic acid and glutamic acid protected on the side chain carboxylic acid group form of esters which impede aspartimide formation in solid phase synthesis of peptides SE9401079L (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SE9401079A SE9401079L (en) 1994-03-30 1994-03-30 New derivatives of aspartic acid and glutamic acid protected on the side chain carboxylic acid group form of esters which impede aspartimide formation in solid phase synthesis of peptides
PCT/SE1995/000337 WO1995026975A1 (en) 1994-03-30 1995-03-30 Acyclic aliphatic branched alkyl groups as constituents of protective groups bound to side chains of amino-acid moieties, and their use in the preparation of peptide, polypeptide or protein structures

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9401079A SE9401079L (en) 1994-03-30 1994-03-30 New derivatives of aspartic acid and glutamic acid protected on the side chain carboxylic acid group form of esters which impede aspartimide formation in solid phase synthesis of peptides

Publications (2)

Publication Number Publication Date
SE9401079D0 SE9401079D0 (en) 1994-03-30
SE9401079L true SE9401079L (en) 1995-10-01

Family

ID=20393486

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9401079A SE9401079L (en) 1994-03-30 1994-03-30 New derivatives of aspartic acid and glutamic acid protected on the side chain carboxylic acid group form of esters which impede aspartimide formation in solid phase synthesis of peptides

Country Status (2)

Country Link
SE (1) SE9401079L (en)
WO (1) WO1995026975A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2589884T3 (en) 2013-12-19 2016-11-16 Merck Patent Gmbh Aspartic acid derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53132539A (en) * 1977-04-22 1978-11-18 Takeda Chem Ind Ltd Protected amino acid or peptide having said protected amino acid residue
JPS57118563A (en) * 1981-01-14 1982-07-23 Takeda Chem Ind Ltd Indole derivative and preparation of peptide
JPS6393796A (en) * 1986-10-09 1988-04-25 Shin Etsu Chem Co Ltd Agent for eliminating protecting group in peptide synthesis
BE1005720A3 (en) * 1992-03-20 1993-12-28 Solvay Process for peptide synthesis and new intermediate synthesis.

Also Published As

Publication number Publication date
SE9401079D0 (en) 1994-03-30
WO1995026975A1 (en) 1995-10-12

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