SE9201281L - Novel human monoclonal antibodies and process for their preparation - Google Patents

Novel human monoclonal antibodies and process for their preparation

Info

Publication number
SE9201281L
SE9201281L SE9201281A SE9201281A SE9201281L SE 9201281 L SE9201281 L SE 9201281L SE 9201281 A SE9201281 A SE 9201281A SE 9201281 A SE9201281 A SE 9201281A SE 9201281 L SE9201281 L SE 9201281L
Authority
SE
Sweden
Prior art keywords
preparation
human monoclonal
monoclonal antibodies
antibodies
novel human
Prior art date
Application number
SE9201281A
Other languages
Swedish (sv)
Other versions
SE9201281D0 (en
Inventor
C Borrebaeck
M Ohlin
Original Assignee
Bioinvent Int Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioinvent Int Ab filed Critical Bioinvent Int Ab
Priority to SE9201281A priority Critical patent/SE9201281L/en
Publication of SE9201281D0 publication Critical patent/SE9201281D0/en
Priority to PCT/SE1993/000343 priority patent/WO1993021952A1/en
Priority to AU42742/93A priority patent/AU4274293A/en
Publication of SE9201281L publication Critical patent/SE9201281L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
    • C07K16/089—Cytomegalovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

New human monoclonal antibodies with neutralizing activity against the cytomegalovirus (CMV). A method for preparation of such antibodies is also described, whereby the antibodies are produced from human peripheral blood lymphocytes. The antibodies are specific for epitopes between aa 552-635 of gp58 or aa 67-86 of gp116 and recognize native gp58/gp116 as well.
SE9201281A 1992-04-23 1992-04-23 Novel human monoclonal antibodies and process for their preparation SE9201281L (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE9201281A SE9201281L (en) 1992-04-23 1992-04-23 Novel human monoclonal antibodies and process for their preparation
PCT/SE1993/000343 WO1993021952A1 (en) 1992-04-23 1993-04-21 Human monoclonal antibodies against cytomegalovirus and method for preparation thereof
AU42742/93A AU4274293A (en) 1992-04-23 1993-04-21 Human monoclonal antibodies against cytomegalovirus and method for preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9201281A SE9201281L (en) 1992-04-23 1992-04-23 Novel human monoclonal antibodies and process for their preparation

Publications (2)

Publication Number Publication Date
SE9201281D0 SE9201281D0 (en) 1992-04-23
SE9201281L true SE9201281L (en) 1993-10-24

Family

ID=20386038

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9201281A SE9201281L (en) 1992-04-23 1992-04-23 Novel human monoclonal antibodies and process for their preparation

Country Status (3)

Country Link
AU (1) AU4274293A (en)
SE (1) SE9201281L (en)
WO (1) WO1993021952A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19756214C1 (en) * 1997-12-17 1999-02-25 Biotest Ag New chimeric human cytomegalovirus (HCMV) polypeptides
WO2004046330A2 (en) 2002-11-15 2004-06-03 Morphotek, Inc. Methods of generating high-production of antibodies from hybridomas created by in vitro immunization
GB0700133D0 (en) 2007-01-04 2007-02-14 Humabs Llc Human cytomegalovirus neutralising antibodies and use thereof
US7947274B2 (en) 2007-01-04 2011-05-24 Humabs, LLC. Human cytomegalovirus neutralising antibodies and use thereof
EP2190876A1 (en) * 2007-08-22 2010-06-02 Ribovax Biotechnologies SA Antibodies against human cytomegalovirus (hcmv)
AU2009223688B2 (en) * 2008-03-10 2014-12-11 Theraclone Sciences, Inc. Compositions and methods for the therapy and diagnosis of cytomegalovirus infections
AU2009272284C1 (en) 2008-07-16 2014-05-15 Institute For Research In Biomedicine Human cytomegalovirus neutralizing antibodies and use thereof
JP4981192B2 (en) 2009-04-01 2012-07-18 株式会社イーベック Monoclonal antibody that binds to a specific discontinuous epitope present in the AD1 region of human cytomegalovirus gB glycoprotein and antigen-binding fragment thereof
KR20120105543A (en) 2009-12-23 2012-09-25 4-안티바디 아게 Binding members for human cytomegalovirus
US20150152166A1 (en) * 2013-04-19 2015-06-04 Theraclone Sciences, Inc. Compositions and methods for the therapy and diagnosis of cytomegalovirus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3650032T2 (en) * 1985-12-06 1995-03-09 Teijin Ltd ANTICYTOMEGALOVIRAL HUMAN MONOCLONAL ANTIBODIES AND THEIR PRODUCTION.

Also Published As

Publication number Publication date
SE9201281D0 (en) 1992-04-23
WO1993021952A1 (en) 1993-11-11
AU4274293A (en) 1993-11-29

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