SE9000377D0 - SYNTHETIC PROCEDURE AND ACID CONTENT HETEROCYCLIC PRODUCT THEREOF - Google Patents

SYNTHETIC PROCEDURE AND ACID CONTENT HETEROCYCLIC PRODUCT THEREOF

Info

Publication number
SE9000377D0
SE9000377D0 SE9000377A SE9000377A SE9000377D0 SE 9000377 D0 SE9000377 D0 SE 9000377D0 SE 9000377 A SE9000377 A SE 9000377A SE 9000377 A SE9000377 A SE 9000377A SE 9000377 D0 SE9000377 D0 SE 9000377D0
Authority
SE
Sweden
Prior art keywords
acid content
synthetic procedure
heterocyclic product
heterocyclic
product
Prior art date
Application number
SE9000377A
Other languages
Swedish (sv)
Other versions
SE9000377L (en
Inventor
M A Avery
Original Assignee
Stanford Res Inst Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int
Publication of SE9000377D0 publication Critical patent/SE9000377D0/en
Publication of SE9000377L publication Critical patent/SE9000377L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Abstract

A process for synthesizing oxygen-containing analogs of the antimalarial agent known as quinghaosu or artemisinin, and in particular compounds of formulae (I) and (II). The process employs as a reactant a vinylsilane that is subjected to an ozonolysis/acidification step which closes the oxygen-containing ring structure. The various products are claimed as aspects of this invention as is their use as antimalarials.
SE9000377A 1986-12-18 1990-02-02 SYNTHETIC PROCEDURE AND ACID CONTENT HETEROCYCLIC PRODUCT THEREOF SE9000377L (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US94355586A 1986-12-18 1986-12-18
US10813887A 1987-10-13 1987-10-13
US10814587A 1987-10-13 1987-10-13
PCT/US1987/003330 WO1988004660A2 (en) 1986-12-18 1987-12-15 Synthesis process and oxygen-containing heterocyclic products thereof

Publications (2)

Publication Number Publication Date
SE9000377D0 true SE9000377D0 (en) 1990-02-02
SE9000377L SE9000377L (en) 1991-08-03

Family

ID=27380423

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8802906A SE8802906L (en) 1986-12-18 1988-08-16 SYNTHETIC PROCEDURE AND ACID CONTENT HETEROCYCLIC PRODUCT THEREOF
SE9000377A SE9000377L (en) 1986-12-18 1990-02-02 SYNTHETIC PROCEDURE AND ACID CONTENT HETEROCYCLIC PRODUCT THEREOF

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE8802906A SE8802906L (en) 1986-12-18 1988-08-16 SYNTHETIC PROCEDURE AND ACID CONTENT HETEROCYCLIC PRODUCT THEREOF

Country Status (7)

Country Link
EP (1) EP0346356A1 (en)
JP (1) JPH01501710A (en)
CH (1) CH679486A5 (en)
DE (1) DE3790698T1 (en)
GB (1) GB2218088B (en)
SE (2) SE8802906L (en)
WO (1) WO1988004660A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8807523D0 (en) * 1988-03-30 1988-05-05 Jefford C W 1,2,4-trioxanes related to arteannuin
US5216175A (en) * 1990-03-23 1993-06-01 Sri International Antimalarial analogs of artemisinin
TW198722B (en) * 1990-05-07 1993-01-21 Hoechst Ag
WO1993008195A1 (en) * 1991-10-14 1993-04-29 The University Of Sydney Cyclic peroxyacetal compounds
US6160004A (en) * 1997-12-30 2000-12-12 Hauser, Inc. C-10 carbon-substituted artemisinin-like trioxane compounds having antimalarial, antiproliferative and antitumor activities
EP0974593A1 (en) * 1998-07-14 2000-01-26 The Hong Kong University of Science & Technology Artemisinin derivatives as antiparasitic agents

Also Published As

Publication number Publication date
GB2218088B (en) 1991-07-10
DE3790698T1 (en) 1988-12-08
JPH01501710A (en) 1989-06-15
GB2218088A (en) 1989-11-08
WO1988004660A2 (en) 1988-06-30
CH679486A5 (en) 1992-02-28
SE8802906D0 (en) 1988-08-16
GB8818816D0 (en) 1988-10-05
SE8802906L (en) 1988-08-16
EP0346356A1 (en) 1989-12-20
SE9000377L (en) 1991-08-03
WO1988004660A3 (en) 1988-08-11

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