SE8603797L - PROCEDURE FOR PREPARING N-SULFAMYL-3- (2-GUANIDINO-TIAZOL-4-YL-METYLTIO) -PROPIONAMIDINE - Google Patents
PROCEDURE FOR PREPARING N-SULFAMYL-3- (2-GUANIDINO-TIAZOL-4-YL-METYLTIO) -PROPIONAMIDINEInfo
- Publication number
- SE8603797L SE8603797L SE8603797A SE8603797A SE8603797L SE 8603797 L SE8603797 L SE 8603797L SE 8603797 A SE8603797 A SE 8603797A SE 8603797 A SE8603797 A SE 8603797A SE 8603797 L SE8603797 L SE 8603797L
- Authority
- SE
- Sweden
- Prior art keywords
- sulfamyl
- guanidino
- metyltio
- tiazol
- propionamidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
Abstract
The invention relates to a new process for the preparation of N-sulfamyl-3-(2-guanidinothiazol-4-yl-methylthio)-propionitrile (famotidine) of the formula (I) <IMAGE> (I) by S-alkylation of 2-guanidino-thiazol-4-yl-methanethiol obtained from S-(2-guanidino-thiazol-4-yl-methyl)-isothiourea dihydrochloride of the formula (III) <IMAGE> (III) by in situ treatment with a base, which comprises carrying out S-alkylation with a N-sulfamyl-3-halopropionamidine of the formula (II) <IMAGE> (II) wherein X stands for halogen.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU853424A HU194845B (en) | 1985-09-11 | 1985-09-11 | Process for production of n-sulphamil-3-/2-guanidintiazolil-4-methil-tio/-propion-amidin |
Publications (2)
Publication Number | Publication Date |
---|---|
SE8603797D0 SE8603797D0 (en) | 1986-09-10 |
SE8603797L true SE8603797L (en) | 1987-03-12 |
Family
ID=10963968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8603797A SE8603797L (en) | 1985-09-11 | 1986-09-10 | PROCEDURE FOR PREPARING N-SULFAMYL-3- (2-GUANIDINO-TIAZOL-4-YL-METYLTIO) -PROPIONAMIDINE |
Country Status (22)
Country | Link |
---|---|
US (1) | US4835281A (en) |
JP (1) | JPH0645609B2 (en) |
KR (1) | KR910000237B1 (en) |
CN (1) | CN1013674B (en) |
AR (1) | AR240319A1 (en) |
AT (1) | AT386824B (en) |
AU (1) | AU587279B2 (en) |
BE (1) | BE905409A (en) |
CA (1) | CA1263120A (en) |
DD (1) | DD249479A5 (en) |
DK (1) | DK169920B1 (en) |
ES (1) | ES2001677A6 (en) |
FI (1) | FI86423C (en) |
GB (1) | GB2180237B (en) |
GE (1) | GEP19960471B (en) |
GR (1) | GR862308B (en) |
HU (1) | HU194845B (en) |
NL (1) | NL8602225A (en) |
NO (1) | NO163010C (en) |
PT (1) | PT83348B (en) |
SE (1) | SE8603797L (en) |
SU (1) | SU1450743A3 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU194845B (en) * | 1985-09-11 | 1988-03-28 | Richter Gedeon Vegyeszet | Process for production of n-sulphamil-3-/2-guanidintiazolil-4-methil-tio/-propion-amidin |
HU196775B (en) * | 1986-08-05 | 1989-01-30 | Richter Gedeon Vegyeszet | Process for production of morfologically unique new modifications of famotidin and medical compositions containing such substances |
IL86330A0 (en) * | 1987-06-22 | 1988-11-15 | Marga Investigacion | Famotidine polymorphic forms and their preparation |
US5856500A (en) * | 1997-03-11 | 1999-01-05 | Albemarle Corporation | Synthesis of thiazole derivatives |
US5731442A (en) * | 1997-03-11 | 1998-03-24 | Albemarle Corporation | Synthesis of thiazole derivatives |
EP1140066A4 (en) * | 1998-11-17 | 2005-11-09 | Nitromed Inc | Nitrosated and nitrosylated h2 receptor antagonist compounds, compositions and methods of use |
US20110143340A1 (en) * | 2007-11-01 | 2011-06-16 | Biocept, Inc. | Non-invasive isolation of fetal nucleic acid |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6056143B2 (en) * | 1979-08-02 | 1985-12-09 | 山之内製薬株式会社 | Amidine derivatives and their production method |
US4808589A (en) * | 1982-02-20 | 1989-02-28 | Smith Kline & French Laboratories Limited | Pyrimidone derivatives |
US4496737A (en) * | 1982-09-27 | 1985-01-29 | Merck & Co., Inc. | Process for preparing sulfamylamidine antisecretory agents |
ES526303A0 (en) * | 1983-10-07 | 1985-04-01 | Inke Sa | PROCEDURE FOR OBTAINING (-1AMINO-3 - ((((2 - ((DIAMINOMETILENE) AMINO) -4-TIAZOLIL) METHYL) THIO) PROPYLIDENE) SULFAMIDE |
ES8506665A1 (en) * | 1984-05-07 | 1985-08-01 | Inke Sa | Methylene-amino-thiazolyl:methyl-thio-propylidene-sulphamide |
ES536322A0 (en) * | 1984-09-27 | 1985-08-01 | Bioiberica | PROCEDURE FOR OBTAINING N-AMINOSOLPHENYL-3 - ((((2-GUANIDIN-4-THIAZONYL) METHYL) THIO) PROPIONAMIDINE |
ES536803A0 (en) * | 1984-10-17 | 1985-08-01 | Inke Sa | PROCEDURE FOR THE OBTAINING OF (1-AMINO-3 (((2 - ((DIAMINO-METHYLENE) AMINO) -4-TIAZOLIL) METHYL) TIO) PROPILIDEN) SULFAMIDE |
HU193608B (en) * | 1985-09-11 | 1987-11-30 | Richter Gedeon Vegyeszet | Process for production of new dervatives of n-sulphanol-propion-amidine |
HU194845B (en) * | 1985-09-11 | 1988-03-28 | Richter Gedeon Vegyeszet | Process for production of n-sulphamil-3-/2-guanidintiazolil-4-methil-tio/-propion-amidin |
JP3751649B2 (en) * | 1994-12-01 | 2006-03-01 | 関西ペイント株式会社 | Temporary protection method for automotive skin coating |
-
1985
- 1985-09-11 HU HU853424A patent/HU194845B/en unknown
-
1986
- 1986-08-22 CA CA000516617A patent/CA1263120A/en not_active Expired
- 1986-09-03 NL NL8602225A patent/NL8602225A/en not_active Application Discontinuation
- 1986-09-08 KR KR1019860007508A patent/KR910000237B1/en not_active IP Right Cessation
- 1986-09-08 AR AR305176A patent/AR240319A1/en active
- 1986-09-09 SU SU864028107A patent/SU1450743A3/en active
- 1986-09-09 DD DD86294264A patent/DD249479A5/en unknown
- 1986-09-09 GR GR862308A patent/GR862308B/en unknown
- 1986-09-10 BE BE0/217144A patent/BE905409A/en not_active IP Right Cessation
- 1986-09-10 NO NO863616A patent/NO163010C/en not_active IP Right Cessation
- 1986-09-10 JP JP61211792A patent/JPH0645609B2/en not_active Expired - Lifetime
- 1986-09-10 GB GB8621742A patent/GB2180237B/en not_active Expired
- 1986-09-10 DK DK434586A patent/DK169920B1/en not_active IP Right Cessation
- 1986-09-10 AU AU62569/86A patent/AU587279B2/en not_active Expired
- 1986-09-10 AT AT0243486A patent/AT386824B/en not_active IP Right Cessation
- 1986-09-10 SE SE8603797A patent/SE8603797L/en not_active Application Discontinuation
- 1986-09-10 PT PT83348A patent/PT83348B/en unknown
- 1986-09-10 FI FI863657A patent/FI86423C/en not_active IP Right Cessation
- 1986-09-11 ES ES8601790A patent/ES2001677A6/en not_active Expired
- 1986-09-11 CN CN86105909A patent/CN1013674B/en not_active Expired
-
1987
- 1987-07-23 US US07/077,095 patent/US4835281A/en not_active Expired - Lifetime
-
1993
- 1993-06-14 GE GEAP1993867A patent/GEP19960471B/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT69178A (en) | PROCESS FOR THE PREPARATION OF ALKYLENEDIAMINE DERIVATIVES | |
RO75256A (en) | PROCESS FOR THE PREPARATION OF 1,2,3, THIAZOLE-5-CARBOXYLIC ACID DERIVATIVES | |
BR8704582A (en) | PROCESS TO PREPARE PYRIDINACARBOXAMIDE DERIVATIVES | |
RO83309A (en) | PROCESS FOR THE PREPARATION OF (-) - N-METHYL-3- (2-METHYL-PHENOXY) -3-PHENYLPROPYLAMINE | |
ES545815A0 (en) | A METHOD FOR PREPARING PIPERAZINE DERIVATIVES | |
RO82508A (en) | PROCESS FOR PREPARING 3- (1-PYPERIDINYLALKYL) -4H-PROCESSED DERIVATIVES FOR THE PREPARATION OF 3- (1-PYPERIDINYLALKYL) -4H-PYRIDO- (1,2-A) -PYRIMIDIN-4-ONE DERIVATIVES | |
MA19996A1 (en) | Process for the preparation of disubstituted proline derivatives | |
SE8603797L (en) | PROCEDURE FOR PREPARING N-SULFAMYL-3- (2-GUANIDINO-TIAZOL-4-YL-METYLTIO) -PROPIONAMIDINE | |
HUT42770A (en) | Process for preparing novel pyrrolo-benzimidazole derivatives, pyrrolo -benzoxazole derivatives and pyrrolo-benzthiazole derivatives and pharmaceutical compositions comprising the same | |
PT73841B (en) | Process for preparing novel guanidine derivatives | |
RO77772A (en) | PROCESS FOR THE PREPARATION OF 2,2-DIMETHYLCYCLOPROPANCARBOXYLIC ACID DERIVATIVES | |
DK165282A (en) | PHENETHANOLAMINE DERIVATIVES, PROCEDURE FOR THEIR PREPARATION OF THEIR USE | |
ES2053707T3 (en) | PROCEDURE FOR THE PREPARATION OF 3,3-DIARYL-ACRYLIC ACID AMIDES. | |
DK439082A (en) | 4-ACYLAMINO-1-AZA-ADAMANTAN COMPOUNDS AND PROCEDURES FOR PREPARING THEREOF | |
FR2442840A1 (en) | PROCESS FOR THE PREPARATION OF PHOTOPOLYMERISABLE UNSATURATED DIGLYCIDYLIC KETONES | |
RO81506A (en) | PROCEDURE FOR PREPARATION OF 1,3,4-TIADIAZOL-2-CARBOXYLIC ACID DERIVATIVES | |
IT1122745B (en) | PROCEDURE FOR THE PRODUCTION OF DICYCLOPENTILEN PARENTESI QUADRA OPEN 2,2'-BIS (4-ALCHIL-6-T-BUTYLPHENOLS) PARENTESI QUADRA CLOSED | |
NO792126L (en) | CARBAZOLE DERIVATIVES. | |
DK222087A (en) | AENE PROCEDURE FOR THE PREPARATION OF CHEMICAL RELATIONSHIPS | |
NO812630L (en) | PROCEDURE FOR PREPARING ALFA-SUBSTITUTED UREIDOBENZYLPENICILLANIC ACID | |
PT75167A (en) | PROCESS FOR THE PREPARATION OF CYSTINE DERIVATIVES | |
FR2430931A1 (en) | PROCESS FOR THE PREPARATION OF AMINE DERIVATIVES OF CIS-BICYCLOOCTYLE | |
JPS5346967A (en) | R-2-(beta-halogenoethyl)-1-methyl-pyrrolidine | |
JPS525729A (en) | Process for preparation of 1,3,5-tri-substituted-benzene derivatives | |
RO77324A (en) | PROCESS FOR THE PREPARATION OF SUBSTITUTED 4,5,6,7-TETRAHYDRO-1H- (OR 2H) INDAZOLAMINE DERIVATIVES |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NAV | Patent application has lapsed |
Ref document number: 8603797-5 Effective date: 19910225 |