SE8503557L - PSYCHOGERIATRIC 1- (2-PURIMIDINYL) -PIPERAZINYL DERIVATIVES OF 1-PYRROLIDIN-2-O - Google Patents

PSYCHOGERIATRIC 1- (2-PURIMIDINYL) -PIPERAZINYL DERIVATIVES OF 1-PYRROLIDIN-2-O

Info

Publication number
SE8503557L
SE8503557L SE8503557A SE8503557A SE8503557L SE 8503557 L SE8503557 L SE 8503557L SE 8503557 A SE8503557 A SE 8503557A SE 8503557 A SE8503557 A SE 8503557A SE 8503557 L SE8503557 L SE 8503557L
Authority
SE
Sweden
Prior art keywords
purimidinyl
psychogeriatric
pyrrolidin
piperazinyl derivatives
alkyl
Prior art date
Application number
SE8503557A
Other languages
Swedish (sv)
Other versions
SE463715B (en
SE8503557D0 (en
Inventor
J P Yevich
R J Mattson
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8503557D0 publication Critical patent/SE8503557D0/en
Publication of SE8503557L publication Critical patent/SE8503557L/en
Publication of SE463715B publication Critical patent/SE463715B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of the general formula <IMAGE> (R<1> is hydrogen or alkyl; R<2> is hydrogen, alkyl or optionally substituted aryl; and X is a bond, <IMAGE> and their salts possess cognition enhancing and/or mild CNS stimulating activity.
SE8503557A 1984-07-23 1985-07-22 PSYCHOGERIATRIC 1- (2-PYRIMIDINYL) -PIPERAZINYL DERIVATIVES OF 1-PYRROLIDIN-2-ONES AND PROCEDURES FOR PREPARING THESE SE463715B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63337184A 1984-07-23 1984-07-23

Publications (3)

Publication Number Publication Date
SE8503557D0 SE8503557D0 (en) 1985-07-22
SE8503557L true SE8503557L (en) 1986-01-24
SE463715B SE463715B (en) 1991-01-14

Family

ID=24539376

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8503557A SE463715B (en) 1984-07-23 1985-07-22 PSYCHOGERIATRIC 1- (2-PYRIMIDINYL) -PIPERAZINYL DERIVATIVES OF 1-PYRROLIDIN-2-ONES AND PROCEDURES FOR PREPARING THESE

Country Status (8)

Country Link
JP (1) JPS61106570A (en)
CA (1) CA1250291A (en)
DK (1) DK333485A (en)
FR (1) FR2567886B1 (en)
GB (1) GB2162843B (en)
HU (1) HU194874B (en)
IT (1) IT1187699B (en)
SE (1) SE463715B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1322199C (en) * 1987-07-15 1993-09-14 Masami Eigyo N-¬(2-oxopyrrolidin-1-yl) acetyl)| piperazine derivatives and drug for senile dementia
US5340812A (en) * 1989-04-22 1994-08-23 John Wyeth & Brother, Limited Piperazine derivatives
DE69033100T2 (en) * 1989-04-22 2000-01-05 Wyeth John & Brother Ltd Piperazine derivatives
US5250528A (en) * 1989-08-02 1993-10-05 Fujisawa Pharmaceutical Co., Ltd. New aminopiperazine derivatives
GB8917687D0 (en) * 1989-08-02 1989-09-20 Fujisawa Pharmaceutical Co Aminopiperazine derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
KR20010030637A (en) 1997-10-09 2001-04-16 후지야마 아키라 New process for producing aminopiperazine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (en) * 1969-11-24 1971-05-24 Bristol Myers Co HETEROCYCLICAL AZASPIRODECANEDIONES AND METHODS FOR THEIR PREPARATION
US4423049A (en) * 1981-12-28 1983-12-27 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
DE3361609D1 (en) * 1982-03-24 1986-02-06 Prodes Sa New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts

Also Published As

Publication number Publication date
SE463715B (en) 1991-01-14
DK333485A (en) 1986-01-24
GB8518452D0 (en) 1985-08-29
JPS61106570A (en) 1986-05-24
FR2567886A1 (en) 1986-01-24
HU194874B (en) 1988-03-28
IT8521657A0 (en) 1985-07-22
DK333485D0 (en) 1985-07-22
HUT38342A (en) 1986-05-28
IT1187699B (en) 1987-12-23
SE8503557D0 (en) 1985-07-22
GB2162843B (en) 1988-04-20
GB2162843A (en) 1986-02-12
FR2567886B1 (en) 1988-03-25
CA1250291A (en) 1989-02-21

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