SE8502051L - ENANTIOMERALLY PURE MONOESTERS OF MALONIC ACID AND AN ENZYMATIC PROCEDURE LIKE INTERMEDIATES FOR PRODUCING THEREOF - Google Patents

ENANTIOMERALLY PURE MONOESTERS OF MALONIC ACID AND AN ENZYMATIC PROCEDURE LIKE INTERMEDIATES FOR PRODUCING THEREOF

Info

Publication number
SE8502051L
SE8502051L SE8502051A SE8502051A SE8502051L SE 8502051 L SE8502051 L SE 8502051L SE 8502051 A SE8502051 A SE 8502051A SE 8502051 A SE8502051 A SE 8502051A SE 8502051 L SE8502051 L SE 8502051L
Authority
SE
Sweden
Prior art keywords
malonic acid
enantiomerally
intermediates
producing
enzymatic procedure
Prior art date
Application number
SE8502051A
Other languages
Swedish (sv)
Other versions
SE453599B (en
SE8502051D0 (en
Inventor
Karl Hult
John Boutelje
Sten Gatenbeck
Torbjorn Norin
Fredrik Bjorkling
Original Assignee
Karl Hult
John Boutelje
Sten Gatenbeck
Torbjorn Norin
Fredrik Bjorkling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karl Hult, John Boutelje, Sten Gatenbeck, Torbjorn Norin, Fredrik Bjorkling filed Critical Karl Hult
Priority to SE8502051A priority Critical patent/SE453599B/en
Publication of SE8502051D0 publication Critical patent/SE8502051D0/en
Publication of SE8502051L publication Critical patent/SE8502051L/en
Publication of SE453599B publication Critical patent/SE453599B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

It has the general formula (I), where R1 and R2 independently are hydrogen, hydroxy or lower alkoxy groups with 1-6 carbon atoms esp. methoxy. Diester is hydrolysed in the presence of a hydrolase enzyme. In particular dimethyl enter of malonic acid with the general formula (II), where R1, R2 are as above. The enzymic hydrolysis is carried out in a mixture of solvents which include water and up to 50 vol. % dimethylsulphoxides.
SE8502051A 1985-04-26 1985-04-26 Pharmaceutical intermediate malonic acid di:ester prepn. SE453599B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SE8502051A SE453599B (en) 1985-04-26 1985-04-26 Pharmaceutical intermediate malonic acid di:ester prepn.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8502051A SE453599B (en) 1985-04-26 1985-04-26 Pharmaceutical intermediate malonic acid di:ester prepn.

Publications (3)

Publication Number Publication Date
SE8502051D0 SE8502051D0 (en) 1985-04-26
SE8502051L true SE8502051L (en) 1986-10-27
SE453599B SE453599B (en) 1988-02-15

Family

ID=20359993

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8502051A SE453599B (en) 1985-04-26 1985-04-26 Pharmaceutical intermediate malonic acid di:ester prepn.

Country Status (1)

Country Link
SE (1) SE453599B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19623142A1 (en) * 1996-06-10 1997-12-11 Huels Chemische Werke Ag Enantiomerically enriched malonic acid monoesters substituted by a tertiary hydrocarbon radical and their preparation

Also Published As

Publication number Publication date
SE453599B (en) 1988-02-15
SE8502051D0 (en) 1985-04-26

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