SE8400689D0 - INTERMEDIATES FOR USING THE PREPARATION OF PHARMACOLOGICALLY ACTIVE 2-METHYLTHI-HYDROPYRIDY COMPOUNDS - Google Patents

INTERMEDIATES FOR USING THE PREPARATION OF PHARMACOLOGICALLY ACTIVE 2-METHYLTHI-HYDROPYRIDY COMPOUNDS

Info

Publication number
SE8400689D0
SE8400689D0 SE8400689A SE8400689A SE8400689D0 SE 8400689 D0 SE8400689 D0 SE 8400689D0 SE 8400689 A SE8400689 A SE 8400689A SE 8400689 A SE8400689 A SE 8400689A SE 8400689 D0 SE8400689 D0 SE 8400689D0
Authority
SE
Sweden
Prior art keywords
compounds
hydropyridy
methylthi
intermediates
preparation
Prior art date
Application number
SE8400689A
Other languages
Swedish (sv)
Other versions
SE446096B (en
SE8400689L (en
Inventor
Y Sato
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of SE8400689D0 publication Critical patent/SE8400689D0/en
Publication of SE8400689L publication Critical patent/SE8400689L/en
Publication of SE446096B publication Critical patent/SE446096B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

2-methyl-dihydropyridine compounds having the formula: <IMAGE> wherein R<1> is phenyl, 3-nitrophenyl, 2-chlorophenyl, 2-trifluoromethylphenyl, 2-methoxyphenyl, 2-allyloxyphenyl, 2,4-dichlorophenyl, 3,4- dichlorophenyl, 3,4-dimethoxyphenyl, 2-tolyl, 4-pyridyl or 2- thienyl, R<2> is propyl, isopropyl, 2-chloroethyl, 2-hydroxyethyl, 2-ethoxyethyl, 2-phenoxyethyl, 2-benzyloxyethyl or 2-(N-benzyl-N-methylamino) ethyl, R<3> is lower alkyl, and R<4> is di(lower)alkoxymethyl, formyl, hydroxymethyl or cyano, provided that, when R<1> is 3-nitrophenyl, then R<2> is 2-hydroxyethyl and R<4> is cyano or formyl, or R<2> is propyl or isopropyl, and pharmaceutically acceptable salts thereof. These compounds have vasodilating and anti-hypertensive activities.
SE8400689A 1978-10-10 1984-02-09 INTERMEDIATES TO USE FOR PREPARATION OF PHARMACOLOGICALLY ACTIVE 2-METHYL-1,4-DIHYDROPYRIDINE COMPOUNDS SE446096B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7839978 1978-10-10

Publications (3)

Publication Number Publication Date
SE8400689D0 true SE8400689D0 (en) 1984-02-09
SE8400689L SE8400689L (en) 1984-02-09
SE446096B SE446096B (en) 1986-08-11

Family

ID=10500226

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7908367A SE446265B (en) 1978-10-10 1979-10-09 2-methyl-1,4-dihydropyridine
SE8400689A SE446096B (en) 1978-10-10 1984-02-09 INTERMEDIATES TO USE FOR PREPARATION OF PHARMACOLOGICALLY ACTIVE 2-METHYL-1,4-DIHYDROPYRIDINE COMPOUNDS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7908367A SE446265B (en) 1978-10-10 1979-10-09 2-methyl-1,4-dihydropyridine

Country Status (10)

Country Link
JP (2) JPS5562065A (en)
BE (1) BE879263A (en)
CA (1) CA1117117A (en)
CH (1) CH642353A5 (en)
DE (1) DE2940833A1 (en)
FR (1) FR2438654A1 (en)
GB (1) GB2036722B (en)
IT (1) IT1125469B (en)
NL (1) NL7907482A (en)
SE (2) SE446265B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7910521L (en) * 1979-12-20 1981-06-21 Haessle Ab NEW 2-METHYL-6-SUBSTITUTED-4- (2,3-DISUBSTITUTED PHENYL) -1,4-DIHYDROPYRIDINE-3,5-DIESTERS WITH HYPOTHESIVE PROPERTIES, AND PROCEDURES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATION
JPS57175164A (en) * 1981-04-18 1982-10-28 Banyu Pharmaceut Co Ltd 1,4-dihydropyridine derivative and its preparation
EP0080220B1 (en) * 1981-11-17 1986-02-19 FISONS plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
ZA83959B (en) * 1982-03-10 1984-09-26 Sandoz Ltd 1,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
CH655110A5 (en) * 1982-09-03 1986-03-27 Otsuka Pharma Co Ltd CARBOSTYRILE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THEM.
DE3312216A1 (en) * 1983-04-05 1984-10-11 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING SYMMETRIC 1,4-DIHYDROPYRIDINE CARBONIC ACID ESTERS
JPS6038322A (en) * 1983-08-11 1985-02-27 Fujisawa Pharmaceut Co Ltd Easily soluble solid preparation containing dihydropyridine-a substance
GB8412208D0 (en) * 1984-05-12 1984-06-20 Pfizer Ltd Quinolone inotropic agents
GB8431119D0 (en) * 1984-12-10 1985-01-16 Fujisawa Pharmaceutical Co Anti-arteriosclerotic composition
GB8602518D0 (en) * 1986-02-01 1986-03-05 Wyeth John & Brother Ltd 1 4-dihydropyridines
JPS63115890A (en) * 1986-10-31 1988-05-20 Nippon Shinyaku Co Ltd 2-substituted 1,4-dihydropyridine derivative
ATE84714T1 (en) * 1987-06-12 1993-02-15 American Cyanamid Co TRANSCUTANEOUS ADMINISTRATION OF PHARMACEUTICALS.
US5114946A (en) * 1987-06-12 1992-05-19 American Cyanamid Company Transdermal delivery of pharmaceuticals
US5045553A (en) * 1987-06-24 1991-09-03 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter
EP0322747B1 (en) * 1987-12-29 1994-03-02 Fujisawa Pharmaceutical Co., Ltd. A brain neuron protecting agent containing a dihydropyridine compound
EP0323604B1 (en) * 1987-12-29 1994-05-11 Fujisawa Pharmaceutical Co., Ltd. A venous extensibility improving and cardiac hypertrophy suppressant agent containing a dihydropyridine compound
JP2007230869A (en) * 2004-04-05 2007-09-13 Takeda Chem Ind Ltd Aldosterone receptor antagonist
CN103951608B (en) * 2009-08-04 2016-04-27 喜德生（苏州）医药科技有限公司 Nilvadipine crystal formation and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
GB1591089A (en) * 1976-12-17 1981-06-10 Fujisawa Pharmaceutical Co 1,4-dihydropyridine derivatives and process for preparation thereof
DE2658183A1 (en) * 1976-12-22 1978-07-06 Bayer Ag 2-POSITION SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS A MEDICINAL PRODUCT

Also Published As

Publication number Publication date
JPS6143343B2 (en) 1986-09-26
CA1117117A (en) 1982-01-26
SE446265B (en) 1986-08-25
JPS6125711B2 (en) 1986-06-17
BE879263A (en) 1980-04-08
JPS61118366A (en) 1986-06-05
FR2438654A1 (en) 1980-05-09
SE446096B (en) 1986-08-11
NL7907482A (en) 1980-04-14
GB2036722A (en) 1980-07-02
GB2036722B (en) 1982-12-01
IT7926362A0 (en) 1979-10-09
FR2438654B1 (en) 1983-01-14
SE8400689L (en) 1984-02-09
DE2940833A1 (en) 1980-04-30
JPS5562065A (en) 1980-05-10
DE2940833C2 (en) 1989-01-26
IT1125469B (en) 1986-05-14
SE7908367L (en) 1980-04-11
CH642353A5 (en) 1984-04-13

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