SE8302643D0 - ANALOGUES OF NEUROHYPOPHYSIAL HORMONES WITH INHIBITORY PROPERTIES - Google Patents

ANALOGUES OF NEUROHYPOPHYSIAL HORMONES WITH INHIBITORY PROPERTIES

Info

Publication number
SE8302643D0
SE8302643D0 SE8302643A SE8302643A SE8302643D0 SE 8302643 D0 SE8302643 D0 SE 8302643D0 SE 8302643 A SE8302643 A SE 8302643A SE 8302643 A SE8302643 A SE 8302643A SE 8302643 D0 SE8302643 D0 SE 8302643D0
Authority
SE
Sweden
Prior art keywords
analogues
residue
group
hormones
hydrogen
Prior art date
Application number
SE8302643A
Other languages
Swedish (sv)
Other versions
SE460051B (en
SE8302643L (en
Inventor
T Barth
K Jost
M Lebl
A Machova
L Servitova
J Slaninova
Original Assignee
Ceskoslovenska Akademie Ved
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CS823340A external-priority patent/CS226923B1/en
Priority claimed from CS620482A external-priority patent/CS229894B1/en
Priority claimed from CS620582A external-priority patent/CS229895B1/en
Priority claimed from CS627182A external-priority patent/CS230327B1/en
Application filed by Ceskoslovenska Akademie Ved filed Critical Ceskoslovenska Akademie Ved
Publication of SE8302643D0 publication Critical patent/SE8302643D0/en
Publication of SE8302643L publication Critical patent/SE8302643L/en
Publication of SE460051B publication Critical patent/SE460051B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Analogues of neurophypophysial hormones with inhibition properties of the general formula I <IMAGE> where all chiral amino acids are of the L-series and the aromatic amino acid in the position 2, indicated with an asterisk*, is of the D-series, and where R<1> and R<2> mean hydrogen or methyl group, R<3> means hydrogen, amino group, or a triglycylamine grouping, R<4> means hydrogen, methyl, ethyl or theoxyl, R<5> means a group S-CH2 or S-S, X<1> means a residue of isoleucine or phenylalanine, X<2> means a residue of leucine or lysine, and X<3> means a glycinamide residue or hydroxyl group, are described. These analogues exhibit inhibition effects towards the uterotonic and pressor activity of natural hormones. The common structural feature of all these analogues is the presence of an aromatic hydrophobic D-amino acid in the position 2.
SE8302643A 1982-05-10 1983-05-09 ANALOGUES OF NEUROHYPHYPHYSIS HORMONS WITH INHIBITIVE PROPERTIES SE460051B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CS823340A CS226923B1 (en) 1982-05-10 1982-05-10 Xytocine analoggues with inhibiting efects and method offreparing same
CS620482A CS229894B1 (en) 1982-08-26 1982-08-26 Analogy of vasopresine and method of its production
CS620582A CS229895B1 (en) 1982-08-26 1982-08-26 Analogy of oxytocine and method of its production
CS627182A CS230327B1 (en) 1982-08-27 1982-08-27 Oxytocine analogue and method of preparing same

Publications (3)

Publication Number Publication Date
SE8302643D0 true SE8302643D0 (en) 1983-05-09
SE8302643L SE8302643L (en) 1983-11-11
SE460051B SE460051B (en) 1989-09-04

Family

ID=27430101

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8302643A SE460051B (en) 1982-05-10 1983-05-09 ANALOGUES OF NEUROHYPHYPHYSIS HORMONS WITH INHIBITIVE PROPERTIES

Country Status (9)

Country Link
BE (1) BE896685A (en)
CH (1) CH653346A5 (en)
DE (1) DE3317092A1 (en)
DK (1) DK199983A (en)
FR (1) FR2526318B1 (en)
GB (1) GB2121052B (en)
IT (1) IT1164212B (en)
NL (1) NL8301663A (en)
SE (1) SE460051B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT398767B (en) * 1988-05-26 1995-01-25 Gebro Broschek Gmbh Process for the purification of a crude peptide by preparative medium pressure liquid chromatography
JP2003335797A (en) * 2000-06-28 2003-11-28 Daicel Chem Ind Ltd Peptide compound and medicine composition containing the compound as active ingredient

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS216722B1 (en) * 1980-06-24 1982-11-26 Michal Lebl Oxytocine analogues and method of making the same

Also Published As

Publication number Publication date
GB2121052B (en) 1985-08-14
FR2526318A1 (en) 1983-11-10
IT1164212B (en) 1987-04-08
DE3317092A1 (en) 1983-11-10
FR2526318B1 (en) 1986-11-14
GB2121052A (en) 1983-12-14
GB8312320D0 (en) 1983-06-08
DK199983D0 (en) 1983-05-05
IT8321002A0 (en) 1983-05-09
NL8301663A (en) 1983-12-01
CH653346A5 (en) 1985-12-31
IT8321002A1 (en) 1984-11-09
SE460051B (en) 1989-09-04
BE896685A (en) 1983-09-01
DK199983A (en) 1983-11-11
SE8302643L (en) 1983-11-11

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