SE8205256L - TRICYCLIC CHINAZOLINONES - Google Patents
TRICYCLIC CHINAZOLINONESInfo
- Publication number
- SE8205256L SE8205256L SE8205256A SE8205256A SE8205256L SE 8205256 L SE8205256 L SE 8205256L SE 8205256 A SE8205256 A SE 8205256A SE 8205256 A SE8205256 A SE 8205256A SE 8205256 L SE8205256 L SE 8205256L
- Authority
- SE
- Sweden
- Prior art keywords
- hydrogen
- alkyl
- halogen
- trifluoromethyl
- represent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compounds of formula I <IMAGE> wherein a) R<1> represents one of the following groups <IMAGE> wherein m represents 0, 1, 2, 3 or 4, p represents 1 or 2, q represents 0, 1 or 2, R7 represents hydrogen or C1-2 alkyl, R8 represents hydrogen, halogen or C1-3 alkyl, R9 represents hydrogen, halogen, C1-4 alkyl, trifluoromethyl or nitro, R2, R3 and R4 represent, independently, hydrogen or C1-2 alkyl, R5 represents hydrogen, halogen, C1-4 alkyl, trifluoromethyl or nitro and R6 represents hydrogen, halogen or C1-3 alkyl, and n represents 0 or 1 whereby at least one of R2, R3 and R4 is hydrogen, or b) R1 represents C1-8 alkyl, unsubstituted or substituted by 1 to 3 fluorine atoms, R5 is in b-position and represents fluorine, chlorine or trifluoromethyl, n represents 0 or 1 and R2, R3, R4 and R6 represent hydrogen, with the proviso that R1 is other than methyl when R5 is chlorine and n is 1, or c) R1 represents C3-6 alkenyl, C3-6 alkynyl, C3-8 cycloalkyl, norbornyl or C3-7 cycloalkyl-(C1-3)-alkyl, R2, R3 and R4 represent, independently, hydrogen or C1-2alkyl, R5 is in b-position and represents halogen, C1-4alkyl or trifluoromethyl, R6 represents hydrogen, halogen or C1-3alkyl, n represents 0 or 1, in free base form or in the form of a pharmaceutically acceptable acid addition salt for use as tranquilizers. These compounds are indicated for use as pharmaceuticals, in particular as tranquilizers.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30248681A | 1981-09-16 | 1981-09-16 | |
| US30248381A | 1981-09-16 | 1981-09-16 | |
| US30248581A | 1981-09-16 | 1981-09-16 | |
| US30248481A | 1981-09-16 | 1981-09-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8205256D0 SE8205256D0 (en) | 1982-09-14 |
| SE8205256L true SE8205256L (en) | 1983-03-17 |
Family
ID=27501816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8205256A SE8205256L (en) | 1981-09-16 | 1982-09-14 | TRICYCLIC CHINAZOLINONES |
Country Status (12)
| Country | Link |
|---|---|
| AU (1) | AU8838582A (en) |
| DE (1) | DE3233766A1 (en) |
| DK (1) | DK410782A (en) |
| ES (1) | ES515693A0 (en) |
| FI (1) | FI823207L (en) |
| FR (1) | FR2512674B1 (en) |
| GB (1) | GB2105721B (en) |
| IT (1) | IT1189355B (en) |
| NL (1) | NL8203587A (en) |
| NZ (1) | NZ201915A (en) |
| PT (1) | PT75555B (en) |
| SE (1) | SE8205256L (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4490371A (en) * | 1983-02-16 | 1984-12-25 | Syntex (U.S.A.) Inc. | N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides |
| US4760065A (en) * | 1986-02-13 | 1988-07-26 | Hardtmann Goetz E | Trifluoromethyl substituted tetracyclic quinazolin-ones having tranquilizing activity |
| CZ281628B6 (en) * | 1991-07-29 | 1996-11-13 | Warner-Lambert Company | Quinazoline derivatives and pharmaceutical preparations based thereon and their use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3631046A (en) * | 1969-05-28 | 1971-12-28 | Sandoz Ag | Tetracyclic quinazolin-ones |
-
1982
- 1982-09-10 FR FR8215474A patent/FR2512674B1/en not_active Expired
- 1982-09-11 DE DE19823233766 patent/DE3233766A1/en not_active Withdrawn
- 1982-09-13 GB GB08226008A patent/GB2105721B/en not_active Expired
- 1982-09-14 SE SE8205256A patent/SE8205256L/en not_active Application Discontinuation
- 1982-09-14 DK DK410782A patent/DK410782A/en not_active Application Discontinuation
- 1982-09-14 ES ES515693A patent/ES515693A0/en active Granted
- 1982-09-14 PT PT75555A patent/PT75555B/en unknown
- 1982-09-14 AU AU88385/82A patent/AU8838582A/en not_active Abandoned
- 1982-09-14 NZ NZ201915A patent/NZ201915A/en unknown
- 1982-09-15 IT IT49124/82A patent/IT1189355B/en active
- 1982-09-16 NL NL8203587A patent/NL8203587A/en not_active Application Discontinuation
- 1982-09-16 FI FI823207A patent/FI823207L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES8402838A1 (en) | 1984-03-01 |
| FR2512674B1 (en) | 1986-01-10 |
| GB2105721A (en) | 1983-03-30 |
| FI823207A0 (en) | 1982-09-16 |
| IT8249124A0 (en) | 1982-09-15 |
| GB2105721B (en) | 1985-11-13 |
| PT75555A (en) | 1982-10-01 |
| ES515693A0 (en) | 1984-03-01 |
| FI823207L (en) | 1983-03-17 |
| IT1189355B (en) | 1988-02-04 |
| SE8205256D0 (en) | 1982-09-14 |
| NZ201915A (en) | 1985-11-08 |
| NL8203587A (en) | 1983-04-18 |
| DK410782A (en) | 1983-03-17 |
| FR2512674A1 (en) | 1983-03-18 |
| AU8838582A (en) | 1983-03-24 |
| PT75555B (en) | 1985-05-31 |
| DE3233766A1 (en) | 1983-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 8205256-4 |