SE8107494L - Beta-carboline derivatives - Google Patents

Beta-carboline derivatives

Info

Publication number
SE8107494L
SE8107494L SE8107494A SE8107494A SE8107494L SE 8107494 L SE8107494 L SE 8107494L SE 8107494 A SE8107494 A SE 8107494A SE 8107494 A SE8107494 A SE 8107494A SE 8107494 L SE8107494 L SE 8107494L
Authority
SE
Sweden
Prior art keywords
alkyl
substd
aralkyl
opt
aryl
Prior art date
Application number
SE8107494A
Other languages
Swedish (sv)
Other versions
SE447573B (en
Inventor
C T Braestrup
J A Christensen
M Engelstoft
Original Assignee
Ferrosan As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan As filed Critical Ferrosan As
Publication of SE8107494L publication Critical patent/SE8107494L/en
Publication of SE447573B publication Critical patent/SE447573B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(A)3-Substd.-beta-carboline derivs. of formula (I) are new. (R' is H, F, Cl, Br, I, NO2, CN, Me, CF3, MeS, NR16R17, NHCOR16, PO(OR23)(OR24), CHR33-OR39, OR18, R35-ethynyl, COOOR2, SR2, SO2R2 or SO2NR21R22; R16 and R17 are H or alkyl, alkenyl or alkynyl each having up to 6C, or aralkyl or cycloalkyl each having up to 10C, all 5 gps. being opt. substd. by halogen, OH, SH, SR23, COOR23, CN, CONR23R24, CH(OR23)OR24 or CH(SR23)SR24 or NR16R17 is a satd. or unsatd. 3- to 7-membered heterocyclic ring opt. substd. by 1-3C alkyl, :S, :O, OR23, SR23 or NR23R24 and a C atom in the ring is opt. replaced by S, O or NR23; R23 and R24 are H or 1-3C alkyl; R33 and R39 are H or 1-3C alkyl and R39 may also be R33CO; R18 is alkyl, aryl or aralkyl each having up to 13C; R35 is H, 1-3C alkyl, 6-12C aryl, CHR33R30 or P(O)(OR23)(OR24); R30 is halogen, OR40 or NR41R42; R40 is H, 1-3C alkyl or 4-5C alkylene to form a 5- or 6-membered heterocyclic ring contg. O; R41 and R42 are H or 1-6C alkyl; R2 is 1-6C alkl; R21 and R2 are H or 1-6C alkyl; m is 1-4; R'' is e.g. H, 1-6C alkyl or 2-6C alkoxyalkyl; R20 is e.g. 1-6C alkyl; n is 1-3; Y s H2, NOR1, CH-COOR3 or CONR4R5; R1 is H, 1-6C alkyl, aryl, aralkyl or COR2; R3 is H or 1-6C alkyl; R4 and R5 are H, 1-6C alkyl, 6-10C aryl or 7-10C aralkyl; Z is e.g. H, or alkoxy or aralkoxy, or CYZ is a 5- or 6-membered heterocyclic ring contg. an O atom, adjoining O and N atoms or up to 4N and opt. substd. b 1-6C alkl, OH or oxo). (B) Cpds. (I) are new when Y is also O with certain limitations on other substituents. Cpds. (I) are CNS active agents esp. tranquillisers, non-sedating anticonvulsants, anti-aggressive agents and anxiolytics and stress protection agents. Dose is 0.1-300 mg daily.
SE8107494A 1981-02-27 1981-12-15 BETA CARBOL INGREDIENTS AND PROCEDURES FOR PREPARING THEREOF SE447573B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK91381 1981-02-27

Publications (2)

Publication Number Publication Date
SE8107494L true SE8107494L (en) 1982-08-28
SE447573B SE447573B (en) 1986-11-24

Family

ID=8098939

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8107494A SE447573B (en) 1981-02-27 1981-12-15 BETA CARBOL INGREDIENTS AND PROCEDURES FOR PREPARING THEREOF

Country Status (4)

Country Link
ES (1) ES516976A0 (en)
FI (1) FI73427C (en)
NO (1) NO158742C (en)
SE (1) SE447573B (en)

Also Published As

Publication number Publication date
ES8308876A1 (en) 1983-10-16
FI73427C (en) 1987-10-09
NO158742B (en) 1988-07-18
FI73427B (en) 1987-06-30
NO158742C (en) 1988-10-26
ES516976A0 (en) 1983-10-16
SE447573B (en) 1986-11-24
NO814260L (en) 1982-08-30
FI814044L (en) 1982-08-28

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