SE8106528L - PREPARATION OF HUMAN MONOCLONAL ANTIBODIES MEDIUM HUMAN HYBRIDOM - Google Patents

PREPARATION OF HUMAN MONOCLONAL ANTIBODIES MEDIUM HUMAN HYBRIDOM

Info

Publication number
SE8106528L
SE8106528L SE8106528A SE8106528A SE8106528L SE 8106528 L SE8106528 L SE 8106528L SE 8106528 A SE8106528 A SE 8106528A SE 8106528 A SE8106528 A SE 8106528A SE 8106528 L SE8106528 L SE 8106528L
Authority
SE
Sweden
Prior art keywords
human
hybridom
preparation
monoclonal antibodies
medium
Prior art date
Application number
SE8106528A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE460907B (en
Inventor
C M Croce
Original Assignee
Wistar Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wistar Inst filed Critical Wistar Inst
Publication of SE8106528L publication Critical patent/SE8106528L/en
Publication of SE460907B publication Critical patent/SE460907B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses

Abstract

The present invention provides a stable, continuous human myeloma cell line which is capable of hybridization with antibody-producing cells of humans and other animals, the cell line being a mutant of GM 1500 human B cells and being deficient in hypoxanthine phosphoribosyltransferase. The invention also comprises processes for the production of hybrid cells employing the stable, HPRT- deficient human myeloma cell line, and processes for the production of antibodies employing such hybrid cells.
SE8106528A 1980-11-07 1981-11-04 HUMAN MYEL CELL LINE, COMPOSITION CONTAINING SUCH CELLS, AND PROCEDURE FOR CELL LINE PREPARATION SE460907B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20483280A 1980-11-07 1980-11-07

Publications (2)

Publication Number Publication Date
SE8106528L true SE8106528L (en) 1982-05-08
SE460907B SE460907B (en) 1989-12-04

Family

ID=22759633

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8106528A SE460907B (en) 1980-11-07 1981-11-04 HUMAN MYEL CELL LINE, COMPOSITION CONTAINING SUCH CELLS, AND PROCEDURE FOR CELL LINE PREPARATION

Country Status (12)

Country Link
JP (1) JPS57126424A (en)
AT (1) AT380898B (en)
AU (1) AU548738B2 (en)
BE (1) BE891003A (en)
CA (1) CA1198066A (en)
CH (1) CH658070A5 (en)
DE (1) DE3144181A1 (en)
FR (1) FR2493865A1 (en)
GB (1) GB2086937B (en)
IT (1) IT1140050B (en)
NZ (1) NZ198851A (en)
SE (1) SE460907B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1200484A (en) * 1981-12-08 1986-02-11 Medical University Of South Carolina Human monoclonal antibodies and lymphokines
CA1247538A (en) * 1982-05-21 1988-12-28 Mark C. Glassy Human-human hybridomas for solid tumors
JPS58201994A (en) * 1982-05-21 1983-11-25 Hideaki Hagiwara Method for producing antigen-specific human immunoglobulin
US4618577A (en) * 1983-02-09 1986-10-21 The Regents Of The University Of California Human-human hybridoma, CLNH5
JPS58205773A (en) * 1982-05-27 1983-11-30 Canon Inc Ink jet printer
DE3379055D1 (en) * 1982-06-09 1989-03-02 Asahi Chemical Ind Method for producing human antibody
US4744982A (en) * 1982-08-24 1988-05-17 Hunter Kenneth W Human monoclonal antibody reactive with polyribosylribitol phosphate
AU567693B2 (en) 1982-09-30 1987-12-03 University Of Rochester Human monoclonal antibodies against bacterial toxins
US4689299A (en) * 1982-09-30 1987-08-25 University Of Rochester Human monoclonal antibodies against bacterial toxins
CA1214123A (en) * 1983-01-20 1986-11-18 Masashi Matsui Cell lines for use in the preparation of hybridoma cells
US4613576A (en) * 1983-03-09 1986-09-23 Sloan-Kettering Institute For Cancer Research Human monoclonal antibodies to cancer cells
US4693966A (en) * 1983-03-11 1987-09-15 Sloan-Kettering Institute For Cancer Research Human monoclonal antibodies from lymphocytes of patients with malignant melanoma
CA1218947A (en) * 1983-04-06 1987-03-10 Pearl M.J. Chen Human hybrid cell lines
JPS6133125A (en) * 1984-07-25 1986-02-17 Morinaga & Co Ltd Human monoclonal anti-lung cancer cell antibody
JPS61104796A (en) * 1984-10-26 1986-05-23 Chemo Sero Therapeut Res Inst Preparation of monoclonal antibody
US4677070A (en) * 1985-04-26 1987-06-30 Cetus Corporation Pseudomonas aeruginosa exotoxin A antibodies, their preparation and use
EP0239102A3 (en) * 1986-03-28 1989-07-12 Tsuji, Kimiyoshi Process for the formation of human-human hybridoma
WO1989009789A1 (en) * 1988-04-07 1989-10-19 Farmitalia Carlo Erba S.R.L. Human monoclonal antibodies against rabies virus
CA2002067A1 (en) 1988-11-09 1990-05-09 Tamotsu Fukuda Parent cell line for producing human hybridomas
US5750106A (en) * 1993-01-28 1998-05-12 Novartis Ag Human monoclonal antibodies to cytomegalovirus

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196265A (en) * 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4172124A (en) * 1978-04-28 1979-10-23 The Wistar Institute Method of producing tumor antibodies

Also Published As

Publication number Publication date
DE3144181A1 (en) 1982-09-09
AU548738B2 (en) 1986-01-02
NZ198851A (en) 1984-07-31
IT8124862A0 (en) 1981-11-04
AT380898B (en) 1986-07-25
GB2086937A (en) 1982-05-19
BE891003A (en) 1982-03-01
JPS57126424A (en) 1982-08-06
AU7716781A (en) 1982-05-13
IT1140050B (en) 1986-09-24
SE460907B (en) 1989-12-04
FR2493865B1 (en) 1984-12-14
FR2493865A1 (en) 1982-05-14
CA1198066A (en) 1985-12-17
CH658070A5 (en) 1986-10-15
ATA476381A (en) 1985-12-15
GB2086937B (en) 1985-05-30

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