SE8104877L - WANT TO MAKE NEW CYTSTATIC SOCIETIES AND PHARMACEUTICAL PREPARATIONS CONTAINING THE NEW SOCIETIES - Google Patents

WANT TO MAKE NEW CYTSTATIC SOCIETIES AND PHARMACEUTICAL PREPARATIONS CONTAINING THE NEW SOCIETIES

Info

Publication number
SE8104877L
SE8104877L SE8104877A SE8104877A SE8104877L SE 8104877 L SE8104877 L SE 8104877L SE 8104877 A SE8104877 A SE 8104877A SE 8104877 A SE8104877 A SE 8104877A SE 8104877 L SE8104877 L SE 8104877L
Authority
SE
Sweden
Prior art keywords
group
societies
new
image
carbon atoms
Prior art date
Application number
SE8104877A
Other languages
Swedish (sv)
Other versions
SE442116B (en
Inventor
L Dancsi
T Keve
G Fekete
E Dezseri
S Gorog
T Acs
C Szantay
L Szabo
K Honty
S Eckhardt
I Hindi
S Kerpel-Fronius
Z Relle
J Sugar
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SE8104877L publication Critical patent/SE8104877L/en
Publication of SE442116B publication Critical patent/SE442116B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A process for the preparation of new cytostatic compounds of general formula (I> <IMAGE> in which either R<4> represents a beta -hydroxyl group and R<3> represents an alpha -ethyl group or R<4> represents a hydrogen atom and R<3> represents a beta -ethyl group; R'' represents a methyl group, a straight chain alkyl group having from 3 to 10 carbon atoms, a branched chain alkyl group having from 3 to 10 carbon atoms and in which the carbon atom attached to the <IMAGE> group has a primary or secondary configuration, or an aralkyl having from 1 to 3 carbon atoms in the alkyl moiety; R<1> represents a methoxy group; and R<2> represents an acetyl group; which comprises reacting a compound of formula (II), <IMAGE> (in which R<1>, R<2>, R<3> and R<4> are as defined above), or an acid addition salt thereof with a large excess of an alcohol of formula R''-OH (III> (wherein R'' is as defined above) in the presence of chromium trioxide at a temperature of from -60 DEG C to -30 DEG C.
SE8104877A 1980-10-22 1981-08-17 VIEW TO PREPARE CYTOSTATIC COMPOUNDS INCLUDING DERIVATIVES OF VINBLASTIN AND LEUROSIDINE WITHOUT PHARMACEUTICAL PREPARATIONS THEREOF SE442116B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU802562A HU181745B (en) 1980-10-22 1980-10-22 Process for producing new vinblastin and leurosidin derivatives

Publications (2)

Publication Number Publication Date
SE8104877L true SE8104877L (en) 1982-04-23
SE442116B SE442116B (en) 1985-12-02

Family

ID=10960005

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8104877A SE442116B (en) 1980-10-22 1981-08-17 VIEW TO PREPARE CYTOSTATIC COMPOUNDS INCLUDING DERIVATIVES OF VINBLASTIN AND LEUROSIDINE WITHOUT PHARMACEUTICAL PREPARATIONS THEREOF

Country Status (15)

Country Link
JP (1) JPS5772992A (en)
AT (1) AT376678B (en)
BE (1) BE889989A (en)
CA (1) CA1174672A (en)
CH (1) CH648320A5 (en)
DE (1) DE3132476A1 (en)
ES (1) ES8300777A1 (en)
FR (1) FR2492384B1 (en)
GB (1) GB2086378B (en)
HU (1) HU181745B (en)
IL (1) IL63593A0 (en)
IT (1) IT1138154B (en)
NL (1) NL8103844A (en)
SE (1) SE442116B (en)
SU (1) SU1053757A3 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU193318B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing new bis- indol derivatives
HU198074B (en) * 1985-06-12 1989-07-28 Richter Gedeon Vegyeszet Process for producing new bis-indole derivatives and pharmaceutical compositions comprising these compounds
JPH0321210U (en) * 1989-07-11 1991-03-01

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899493A (en) * 1972-12-29 1975-08-12 Richter Gedeon Vegyeszet Chromic acid oxidation of vinblastine sulfate to form vincristine
HU178706B (en) * 1979-04-23 1982-06-28 Richter Gedeon Vegyeszet Process for preparing bis-indole alkaloids and acid addition salts thereof
JPS56128643A (en) * 1980-03-13 1981-10-08 Sintokogio Ltd Vertical flaskless type molding machine

Also Published As

Publication number Publication date
SE442116B (en) 1985-12-02
ES505310A0 (en) 1982-12-01
FR2492384B1 (en) 1986-04-04
GB2086378A (en) 1982-05-12
CA1174672A (en) 1984-09-18
BE889989A (en) 1982-02-17
ES8300777A1 (en) 1982-12-01
NL8103844A (en) 1982-05-17
CH648320A5 (en) 1985-03-15
AT376678B (en) 1984-12-27
FR2492384A1 (en) 1982-04-23
JPS5772992A (en) 1982-05-07
SU1053757A3 (en) 1983-11-07
HU181745B (en) 1983-11-28
GB2086378B (en) 1984-07-25
DE3132476A1 (en) 1982-06-09
IT8123540A0 (en) 1981-08-17
JPH0161118B2 (en) 1989-12-27
DE3132476C2 (en) 1991-04-18
IL63593A0 (en) 1981-11-30
ATA358681A (en) 1984-05-15
IT1138154B (en) 1986-09-17

Similar Documents

Publication Publication Date Title
ES2005746A6 (en) Process for the preparation of aryl-piperidine esters.
ATE35417T1 (en) PROCESS FOR THE PREPARATION OF PHOSPHORUS-CONTAINING CYANHYDRINE DERIVATIVES.
SE8104877L (en) WANT TO MAKE NEW CYTSTATIC SOCIETIES AND PHARMACEUTICAL PREPARATIONS CONTAINING THE NEW SOCIETIES
KR840000521A (en) Process for preparing 3-methylflavone-8-carboxylic acid esters
SE7706509L (en) SPIRO ((7-ACYLTIO-4-OSTREN OR-ANDROSTEN-3-ON) -17 BETA, 2 &#39;- (4&#39;-CARBONIC ACID-1&#39;-OXACYCLOPENTAN-5&#39;-ON)) AND ESTRES THEREOF
ES8305727A1 (en) Synthesis of 3,4-diphenyl-5-methylpyrazole derivatives.
GB2017087A (en) Process for the preparation of xanthone derivatives
SE8104878L (en) NEW, CYTOSTATOSIAN SOCIETIES, SET FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE SOCIETIES
DK240086A (en) PHENOLIC DERIVATIVES, PHARMACEUTICALS CONTAINING THE DERIVATIVES AND THE PREPARATION OF THE DERIVATIVES
GB2001062A (en) Preparation of Pyridinecarboxylic acid piperazides
ATE18208T1 (en) N-(4-HYDROXYPHENYL)ACETIC ACID ESTERS FROM 5BENZOYL-1-METHYLPYRROL-2-ACETIC ACID.
Sasaki et al. The conversion of saligenin cyclic methyl phosphorothionate into the thiolate analogs and a new rearrangement reaction
DE3060236D1 (en) Thiazole derivatives, their preparation and medicaments containing them
AU541928B2 (en) Branched s-alkyl phosphonodithioic halides
DK193180A (en) PROCEDURE FOR THE PREPARATION OF 2-AMINOALKYL5-PYRIDINOLES THEIR ACID ADDITION SALTS AND PREPARATIONS CONTAINING THESE COMPOUNDS
DE3061578D1 (en) An alpha-methyl-4(2&#39;-thienyl-carbonyl)phenyl acetic acid derivative, process for its preparation and its pharmaceutical use
SE8000734L (en) 2-AROYL-FORMYL-SUBSTITUTED PYRROL-DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF
DK145948C (en) PROCEDURE FOR PREPARING SULPHONIMIDOYLXANTHON-2-CARBOXYLIC ACID DERIVATIVES
JPS5547687A (en) Preparaton of oxazoline derivative
GB2022075A (en) Lactam-N-acetic acids and the preparation thereof
CS235153B1 (en) 2-(substituted)-4,5-dichlor-3-oxo-2h-pyridazines
GB1057341A (en) Process for the production of 0,0-dialkyl dithiophosphoryl fatty acid amides

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8104877-9

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8104877-9

Format of ref document f/p: F