SE7901706L - BENZYLIDE DERIVATIVES - Google Patents

BENZYLIDE DERIVATIVES

Info

Publication number
SE7901706L
SE7901706L SE7901706A SE7901706A SE7901706L SE 7901706 L SE7901706 L SE 7901706L SE 7901706 A SE7901706 A SE 7901706A SE 7901706 A SE7901706 A SE 7901706A SE 7901706 L SE7901706 L SE 7901706L
Authority
SE
Sweden
Prior art keywords
alkyl
compounds
ch3o
exception
benzyl
Prior art date
Application number
SE7901706A
Other languages
Swedish (sv)
Inventor
J P Kaplan
B M Raizon
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7805578A external-priority patent/FR2418222A2/en
Priority claimed from FR7820940A external-priority patent/FR2430936A1/en
Application filed by Synthelabo filed Critical Synthelabo
Publication of SE7901706L publication Critical patent/SE7901706L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds corresponding to the formula (I> <IMAGE> in which X1, X2, X3 and X4 each represent, independently of one another, a hydrogen or halogen atom or a radical CH3, CH3O, NO2, CF3, C(CH3)3 or CH3CONH, n represents an integer ranging from 1 to 10, R is a radical OH, OM (M=alkali metal), NH2, NH-cycloalkyl, NH-phenyl, NH-benzyl, NH-alkyl, N-(alkyl)2 or N-(alkyl)- (benzyl), and R' represents a hydrogen atom or an alkyl, the alkyls having from 1 to 4 carbon atoms, with the exception of the compounds in which R'=H when X1, X2 and X3 are each, independently of one another, H, Hal, CH3 or CH3O and X4=H and with the exception of the compound in which R'=H, X1=X3=X4=H, X2=5-Cl, n=1 and R=OH. The compounds are anti- convulsants and are useful in treating disorders of the central nervous system, e.g. epilepsy. Processes for preparing them and pharmaceutical compositions containing them are also claimed.
SE7901706A 1978-02-27 1979-02-26 BENZYLIDE DERIVATIVES SE7901706L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7805578A FR2418222A2 (en) 1975-08-01 1978-02-27 Alpha-phenyl 2-hydroxy-benzylidene amino-alkanoic acid derivs. - and novel di:phenyl-ketone intermediates, useful as anticonvulsants for treating epilepsy
FR7820940A FR2430936A1 (en) 1978-07-13 1978-07-13 Alpha-phenyl 2-hydroxy-benzylidene amino-alkanoic acid derivs. - and novel di:phenyl-ketone intermediates, useful as anticonvulsants for treating epilepsy

Publications (1)

Publication Number Publication Date
SE7901706L true SE7901706L (en) 1979-08-28

Family

ID=26220461

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7901706A SE7901706L (en) 1978-02-27 1979-02-26 BENZYLIDE DERIVATIVES

Country Status (20)

Country Link
JP (1) JPS54125644A (en)
AT (1) AT365564B (en)
AU (1) AU520618B2 (en)
BE (1) BE874488A (en)
CA (1) CA1119613A (en)
CH (1) CH637112A5 (en)
DE (1) DE2907379A1 (en)
DK (1) DK82079A (en)
ES (1) ES478070A1 (en)
FI (1) FI790656A (en)
GB (1) GB2021559B (en)
GR (1) GR66971B (en)
IE (1) IE47930B1 (en)
IT (1) IT1113010B (en)
LU (1) LU80974A1 (en)
NL (1) NL7901474A (en)
NO (1) NO790646L (en)
NZ (1) NZ189769A (en)
PT (1) PT69288A (en)
SE (1) SE7901706L (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0047516B1 (en) * 1980-09-04 1984-01-04 Toray Industries, Inc. Propylamine derivative and process of manufacturing the same
JPS5746951A (en) * 1980-09-04 1982-03-17 Toray Ind Inc Production of 2-amino-4-cyanobutyric derivative
FR2536746A1 (en) * 1982-11-29 1984-06-01 Synthelabo ALKYL BENZYLIDENIC DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2544308B1 (en) * 1983-04-14 1985-06-14 Synthelabo SUBSTITUTED ETHINS, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
EP0367671B1 (en) * 1988-11-03 1993-07-28 Fournier Industrie Et Sante Novel beta-d-phenylthioxylosides, their method of preparation and their use as pharmaceuticals
WO1991007380A1 (en) * 1989-11-08 1991-05-30 Dunlena Pty. Ltd. Arthropodicides
JP2005232103A (en) * 2004-02-20 2005-09-02 Nagase & Co Ltd Optically active vicinaldiamine and method for producing the same

Also Published As

Publication number Publication date
NZ189769A (en) 1981-07-13
CH637112A5 (en) 1983-07-15
IT7920543A0 (en) 1979-02-26
AU4460279A (en) 1979-09-06
JPS54125644A (en) 1979-09-29
AT365564B (en) 1982-01-25
CA1119613A (en) 1982-03-09
GR66971B (en) 1981-05-15
ES478070A1 (en) 1979-07-01
ATA149179A (en) 1981-06-15
GB2021559A (en) 1979-12-05
GB2021559B (en) 1982-07-07
AU520618B2 (en) 1982-02-11
IT1113010B (en) 1986-01-20
BE874488A (en) 1979-08-27
DK82079A (en) 1979-08-28
NO790646L (en) 1979-08-28
IE47930B1 (en) 1984-07-25
FI790656A (en) 1979-08-28
DE2907379A1 (en) 1979-09-06
LU80974A1 (en) 1980-09-24
IE790556L (en) 1979-08-27
PT69288A (en) 1979-03-01
NL7901474A (en) 1979-08-29

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