SE7607534L - AZEPIN ASSOCIATIONS - Google Patents

AZEPIN ASSOCIATIONS

Info

Publication number
SE7607534L
SE7607534L SE7607534A SE7607534A SE7607534L SE 7607534 L SE7607534 L SE 7607534L SE 7607534 A SE7607534 A SE 7607534A SE 7607534 A SE7607534 A SE 7607534A SE 7607534 L SE7607534 L SE 7607534L
Authority
SE
Sweden
Prior art keywords
isomers
compounds
azepin
associations
mixture
Prior art date
Application number
SE7607534A
Other languages
Swedish (sv)
Other versions
SE424076B (en
Inventor
J Rokach
J G Atkinson
C S Rooney
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SE7607534L publication Critical patent/SE7607534L/en
Publication of SE424076B publication Critical patent/SE424076B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Pyrrolo[2,1-b]-3-benzazepines of the formula <IMAGE> and their salts and cis/trans geometrical isomers are prepared in pure form or as mixture. The substituents are defined in Claim 1. These compounds are obtained by dehydration of corresponding compounds which have a hydroxyl group in position 11. The isomers, preferably the E isomer, can be obtained from the mixture of isomers by chromatographic separation. The resulting compounds can be used as skeletal muscle relaxants or sedatives.
SE7607534A 1975-07-02 1976-07-01 ANALOGY PROCEDURE FOR PREPARATION OF PYRROLO (2,1-B) (3) BENZOAZEPINE COMPOUNDS SE424076B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59243675A 1975-07-02 1975-07-02

Publications (2)

Publication Number Publication Date
SE7607534L true SE7607534L (en) 1977-01-03
SE424076B SE424076B (en) 1982-06-28

Family

ID=24370639

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7607534A SE424076B (en) 1975-07-02 1976-07-01 ANALOGY PROCEDURE FOR PREPARATION OF PYRROLO (2,1-B) (3) BENZOAZEPINE COMPOUNDS

Country Status (18)

Country Link
JP (1) JPS527996A (en)
AU (1) AU499122B2 (en)
BE (1) BE843678A (en)
CA (1) CA1092105A (en)
CH (5) CH626366A5 (en)
CY (1) CY1091A (en)
DE (2) DE2629877A1 (en)
ES (1) ES449432A1 (en)
FR (1) FR2315935A1 (en)
GB (1) GB1499047A (en)
GR (1) GR60851B (en)
HK (1) HK60580A (en)
HU (1) HU177866B (en)
MY (1) MY8100227A (en)
NL (1) NL188287C (en)
PT (1) PT65295B (en)
SE (1) SE424076B (en)
ZA (1) ZA763990B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148903A (en) * 1977-07-28 1979-04-10 Merck & Co., Inc. Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
JPH0487401U (en) * 1990-12-06 1992-07-29
US6271392B1 (en) 1994-10-07 2001-08-07 Rhone-Poulenc Inc. Intermediates useful for the synthesis of 1-arylpyrrole pesticides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3428677A (en) * 1962-09-24 1969-02-18 Merck & Co Inc Chemical compounds and methods of preparing same
US3499037A (en) * 1966-05-31 1970-03-03 Merck & Co Inc Preparation of trifluoromethyl substituted dibenzocycloheptenes

Also Published As

Publication number Publication date
DE2629877A1 (en) 1977-01-20
ZA763990B (en) 1978-02-22
NL188287B (en) 1991-12-16
CH626618A5 (en) 1981-11-30
NL7607347A (en) 1977-01-04
CH626616A5 (en) 1981-11-30
CA1092105A (en) 1980-12-23
AU499122B2 (en) 1979-04-05
FR2315935A1 (en) 1977-01-28
CH626893A5 (en) 1981-12-15
AU1548876A (en) 1978-01-05
CY1091A (en) 1980-12-27
PT65295B (en) 1978-05-10
PT65295A (en) 1976-07-01
JPH0132225B2 (en) 1989-06-29
HK60580A (en) 1980-11-07
HU177866B (en) 1982-01-28
NL188287C (en) 1992-05-18
MY8100227A (en) 1981-12-31
SE424076B (en) 1982-06-28
GB1499047A (en) 1978-01-25
JPS527996A (en) 1977-01-21
DE2661014A1 (en) 1985-07-04
GR60851B (en) 1978-08-31
CH626366A5 (en) 1981-11-13
ES449432A1 (en) 1977-12-16
FR2315935B1 (en) 1978-11-17
DE2661014C2 (en) 1989-01-05
DE2629877C2 (en) 1989-01-05
CH626617A5 (en) 1981-11-30
BE843678A (en) 1977-01-03

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