SE7603344L - ASSOCIATIONS WITH ANTIDEPRESSIVE EFFECT - Google Patents
ASSOCIATIONS WITH ANTIDEPRESSIVE EFFECTInfo
- Publication number
- SE7603344L SE7603344L SE7603344A SE7603344A SE7603344L SE 7603344 L SE7603344 L SE 7603344L SE 7603344 A SE7603344 A SE 7603344A SE 7603344 A SE7603344 A SE 7603344A SE 7603344 L SE7603344 L SE 7603344L
- Authority
- SE
- Sweden
- Prior art keywords
- methyl
- hydrogen
- associations
- substances
- depressive
- Prior art date
Links
- 230000001430 anti-depressive effect Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 102000004316 Oxidoreductases Human genes 0.000 abstract 1
- 108090000854 Oxidoreductases Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 229910052801 chlorine Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/58—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C313/08—Sulfenic acids; Derivatives thereof
- C07C313/10—Sulfenic acids; Esters thereof
- C07C313/12—Sulfenic acids; Esters thereof having sulfur atoms of sulfenic groups bound to acyclic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The novel compounds of formula I wherein R is hydrogen, methyl or chlorine, R1 is oxygen or sulphur, R2 is OCH2, CH20CH2, OC2H40CH2, R3 is hydrogen or methyl, n and p are 0 or 1 and n + p is 0 or 1 and salts thereof have a very powerful anti-depressive activity which for a considerable part, and in some substances even entirely, is based on serotonine potentiation. Monoamino oxidase inhibition does not contribute to the anti-depressive effect. The substances have a low toxicity and are substantially free from side effects. The compounds can be synthesized and processed to compositions according to known methods.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7503307A NL7503307A (en) | 1975-03-20 | 1975-03-20 | ANTIDEPRESSIVE CONNECTIONS. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE7603344L true SE7603344L (en) | 1976-09-21 |
Family
ID=19823421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7603344A SE7603344L (en) | 1975-03-20 | 1976-03-17 | ASSOCIATIONS WITH ANTIDEPRESSIVE EFFECT |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS51125344A (en) |
| AR (2) | AR212811A1 (en) |
| AT (1) | AT340894B (en) |
| AU (1) | AU502701B2 (en) |
| BE (1) | BE839741A (en) |
| CA (1) | CA1077964A (en) |
| DD (1) | DD128331A5 (en) |
| DE (1) | DE2610302A1 (en) |
| DK (1) | DK115676A (en) |
| ES (1) | ES446189A1 (en) |
| FI (1) | FI760696A (en) |
| FR (1) | FR2304332A1 (en) |
| GB (1) | GB1533063A (en) |
| GR (1) | GR60051B (en) |
| HU (1) | HU171160B (en) |
| IE (1) | IE43826B1 (en) |
| IL (1) | IL49236A (en) |
| NL (1) | NL7503307A (en) |
| PL (3) | PL100040B1 (en) |
| SE (1) | SE7603344L (en) |
| ZA (1) | ZA761386B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7256191B2 (en) | 2000-04-24 | 2007-08-14 | Aryx Therapeutics | Materials and methods for the treatment of depression |
| AU5565401A (en) | 2000-04-24 | 2001-11-07 | Aryx Therapeutics | Materials and methods for the treatment of depression |
-
1975
- 1975-03-20 NL NL7503307A patent/NL7503307A/en not_active Application Discontinuation
-
1976
- 1976-03-08 ZA ZA761386A patent/ZA761386B/en unknown
- 1976-03-12 DE DE2610302A patent/DE2610302A1/en not_active Withdrawn
- 1976-03-17 GR GR50330A patent/GR60051B/en unknown
- 1976-03-17 GB GB10706/76A patent/GB1533063A/en not_active Expired
- 1976-03-17 FI FI760696A patent/FI760696A/fi not_active Application Discontinuation
- 1976-03-17 PL PL1976199546A patent/PL100040B1/en unknown
- 1976-03-17 IL IL49236A patent/IL49236A/en unknown
- 1976-03-17 DK DK115676A patent/DK115676A/en unknown
- 1976-03-17 SE SE7603344A patent/SE7603344L/en not_active Application Discontinuation
- 1976-03-17 CA CA248,103A patent/CA1077964A/en not_active Expired
- 1976-03-17 DD DD7600191890A patent/DD128331A5/en unknown
- 1976-03-17 PL PL1976188001A patent/PL100612B1/en unknown
- 1976-03-17 HU HU76PI00000515A patent/HU171160B/en unknown
- 1976-03-17 AT AT195276A patent/AT340894B/en not_active IP Right Cessation
- 1976-03-17 PL PL1976199547A patent/PL101882B1/en unknown
- 1976-03-18 IE IE570/76A patent/IE43826B1/en unknown
- 1976-03-18 ES ES446189A patent/ES446189A1/en not_active Expired
- 1976-03-18 AU AU12142/76A patent/AU502701B2/en not_active Expired
- 1976-03-18 BE BE165313A patent/BE839741A/en unknown
- 1976-03-19 JP JP51029391A patent/JPS51125344A/en active Pending
- 1976-03-19 FR FR7608015A patent/FR2304332A1/en active Granted
- 1976-03-19 AR AR262633A patent/AR212811A1/en active
- 1976-12-07 AR AR265765A patent/AR213298A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| DE2610302A1 (en) | 1976-09-30 |
| CA1077964A (en) | 1980-05-20 |
| AR213298A1 (en) | 1979-01-15 |
| FI760696A (en) | 1976-09-21 |
| AU502701B2 (en) | 1979-08-02 |
| DD128331A5 (en) | 1977-11-09 |
| GR60051B (en) | 1978-04-04 |
| HU171160B (en) | 1977-11-28 |
| PL100612B1 (en) | 1978-10-31 |
| FR2304332B1 (en) | 1978-12-08 |
| AU1214276A (en) | 1977-09-22 |
| AR212811A1 (en) | 1978-10-13 |
| NL7503307A (en) | 1976-09-22 |
| IE43826B1 (en) | 1981-06-03 |
| JPS51125344A (en) | 1976-11-01 |
| DK115676A (en) | 1976-09-21 |
| AT340894B (en) | 1978-01-10 |
| PL100040B1 (en) | 1978-08-31 |
| ZA761386B (en) | 1977-10-26 |
| GB1533063A (en) | 1978-11-22 |
| ATA195276A (en) | 1977-05-15 |
| IL49236A (en) | 1978-08-31 |
| IE43826L (en) | 1976-09-20 |
| PL101882B1 (en) | 1979-02-28 |
| IL49236A0 (en) | 1976-05-31 |
| FR2304332A1 (en) | 1976-10-15 |
| BE839741A (en) | 1976-09-20 |
| ES446189A1 (en) | 1977-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 7603344-8 |