SE7602122L - NEW PIPERAZINYLIMINORIFAMYCINS AND WAYS TO PRODUCE THE SAME - Google Patents

NEW PIPERAZINYLIMINORIFAMYCINS AND WAYS TO PRODUCE THE SAME

Info

Publication number
SE7602122L
SE7602122L SE7602122A SE7602122A SE7602122L SE 7602122 L SE7602122 L SE 7602122L SE 7602122 A SE7602122 A SE 7602122A SE 7602122 A SE7602122 A SE 7602122A SE 7602122 L SE7602122 L SE 7602122L
Authority
SE
Sweden
Prior art keywords
group
same
piperazinyliminorifamycins
ways
produce
Prior art date
Application number
SE7602122A
Other languages
Swedish (sv)
Other versions
SE420728B (en
Inventor
R Chricchio
V Arioli
Original Assignee
Lepetit Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit Spa filed Critical Lepetit Spa
Publication of SE7602122L publication Critical patent/SE7602122L/en
Publication of SE420728B publication Critical patent/SE420728B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Novel rifamycins characterized by the following structural formula <IMAGE> WHEREIN Me represents a methyl group, n represents 3, 4, 5 or 6; g represents 0, 1 or 2; and each R represents a lower alkyl group selected from methyl or ethyl substituting for a hydrogen atom of a -CH2- group; and wherein, when g is 2, the two lower alkyl groups may replace hydrogen atoms of two different methylene groups as well as hydrogen atoms of the same methylene group. The compounds of this invention possess a broad spectrum antibacterial utility accompanied by a low toxicity.
SE7602122A 1975-03-05 1976-02-23 PUT TO MAKE PIPERAZINYLIMINORIFAMYCINES SE420728B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB10020/75A GB1478563A (en) 1975-03-05 1975-03-05 Rifamycin derivatives

Publications (2)

Publication Number Publication Date
SE7602122L true SE7602122L (en) 1976-09-06
SE420728B SE420728B (en) 1981-10-26

Family

ID=9959968

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7602122A SE420728B (en) 1975-03-05 1976-02-23 PUT TO MAKE PIPERAZINYLIMINORIFAMYCINES

Country Status (27)

Country Link
US (1) US4002752A (en)
JP (1) JPS51113900A (en)
AR (1) AR210113A1 (en)
AT (1) AT344896B (en)
BE (1) BE839255A (en)
CA (1) CA1057748A (en)
CH (1) CH610325A5 (en)
DD (1) DD123888A5 (en)
DE (1) DE2608218C3 (en)
DK (1) DK136655B (en)
ES (1) ES445790A1 (en)
FI (1) FI59102C (en)
FR (1) FR2302742A1 (en)
GB (1) GB1478563A (en)
HK (1) HK35282A (en)
HU (1) HU170451B (en)
IE (1) IE42881B1 (en)
KE (1) KE3099A (en)
LU (1) LU74478A1 (en)
MX (1) MX3737E (en)
NL (1) NL165745C (en)
NO (1) NO143796C (en)
PT (1) PT64866B (en)
SE (1) SE420728B (en)
SU (1) SU575030A3 (en)
YU (1) YU39477B (en)
ZA (1) ZA761043B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2728869A1 (en) * 1976-06-25 1977-12-29 Antibiotice Iasi Intreprindere Antibacterial derivs. of (3)-formyl-rifamycin SV - prepd. by reaction with hydrazines, acylhydrazines or hydroxylamines
GR64108B (en) * 1977-04-15 1980-01-24 Dso Pharmachim Method for the preparation of azomethine-derivatives of rifamycin s.v
GB1576886A (en) * 1977-04-20 1980-10-15 Lepetit Spa Rifamycin derivatives
GB1594134A (en) * 1977-11-25 1981-07-30 Holco Investment Inc Rifamycins
AU536524B2 (en) * 1979-06-28 1984-05-10 Gruppo Lepetit S.P.A. Water soluble hydrozones of 3-formylifamyan
US4447432A (en) * 1981-11-17 1984-05-08 Farmitalia Carlo Erba S.P.A. Azino rifamycins
US4681938A (en) * 1984-08-27 1987-07-21 Ciba-Geigy Corporation Novel polycyclic hydrazones of rifamycins, their manufacture, and their pharmaceutical compositions for treating tuberculosis
ATE47857T1 (en) * 1985-10-18 1989-11-15 Ciba Geigy Ag SUBSTITUTED 4-BENZYL-PIPERAZINYL COMPOUNDS.
US4916126A (en) * 1987-09-25 1990-04-10 Ciba-Geigy Corporation Diacyl derivatives of 4-(trialkylbenzyl)-piperazinyl compounds
GB8816620D0 (en) * 1988-07-13 1988-08-17 Lepetit Spa Rifapentine hydrohalides
KR0170000B1 (en) * 1990-06-29 1999-02-01 레나토 스가르비 Pure crystalline form of rifapentine
WO2007096703A2 (en) 2005-08-11 2007-08-30 Targanta Therapeutics Inc. Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
EP2324041A4 (en) 2008-08-13 2012-06-13 Targanta Therapeutics Corp Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
RU2496475C2 (en) 2011-10-26 2013-10-27 Александр Васильевич Иващенко Pharmaceutical composition and kit for treating bacterial infections
CA2881958C (en) 2012-08-13 2019-08-27 Adipharm Ead Pharmaceutical formulations containing 3-(4-cinnamyl-1-piperazinyl) amino derivatives of 3-formylrifamycin sv and 3-formylrifamycin s and a process of their preparation
CN103951677B (en) * 2014-03-17 2016-04-06 四川省长征药业股份有限公司 The preparation method of rifapentine
WO2022225384A1 (en) * 2021-04-21 2022-10-27 Interquim, S.A. De C.V. Method for obtaining rifapentine with a new crystalline form
CN115047122B (en) * 2022-06-29 2023-05-02 重庆华邦胜凯制药有限公司 Method for analyzing impurities generated in rifapentine and synthesis process thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR208F (en) * 1964-07-31
AR205434A1 (en) * 1972-03-27 1976-05-07 Lepetit Spa PROCESS FOR THE PREPARATION OF 3-ACILHIDRAZONOMETIL RIFAMICINAS SV
GB1392272A (en) * 1972-05-31 1975-04-30 Lepetit Spa 3-formylrifamycin azines

Also Published As

Publication number Publication date
JPS51113900A (en) 1976-10-07
ZA761043B (en) 1977-01-26
JPS5530797B2 (en) 1980-08-13
BE839255A (en) 1976-09-06
NO143796C (en) 1981-04-15
DD123888A5 (en) 1977-01-19
PT64866A (en) 1976-04-01
IE42881L (en) 1976-09-05
FI59102C (en) 1981-06-10
AR210113A1 (en) 1977-06-30
NL7602191A (en) 1976-09-07
AT344896B (en) 1978-08-10
CA1057748A (en) 1979-07-03
MX3737E (en) 1981-06-05
LU74478A1 (en) 1976-09-01
DK136655B (en) 1977-11-07
US4002752A (en) 1977-01-11
DE2608218C3 (en) 1981-12-10
HK35282A (en) 1982-08-13
DE2608218A1 (en) 1976-09-16
PT64866B (en) 1977-07-20
SE420728B (en) 1981-10-26
YU57276A (en) 1982-06-30
GB1478563A (en) 1977-07-06
NO760549L (en) 1976-09-07
ATA162876A (en) 1977-12-15
AU1170476A (en) 1977-09-08
DK78476A (en) 1976-09-06
FR2302742B1 (en) 1979-10-12
FI760561A (en) 1976-09-06
NL165745C (en) 1981-05-15
ES445790A1 (en) 1977-06-01
FI59102B (en) 1981-02-27
YU39477B (en) 1984-12-31
IE42881B1 (en) 1980-11-05
FR2302742A1 (en) 1976-10-01
DE2608218B2 (en) 1981-02-26
NO143796B (en) 1981-01-05
NL165745B (en) 1980-12-15
DK136655C (en) 1978-04-17
CH610325A5 (en) 1979-04-12
KE3099A (en) 1981-02-13
HU170451B (en) 1977-06-28
SU575030A3 (en) 1977-09-30

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