SE7500798L - - Google Patents
Info
- Publication number
- SE7500798L SE7500798L SE7500798A SE7500798A SE7500798L SE 7500798 L SE7500798 L SE 7500798L SE 7500798 A SE7500798 A SE 7500798A SE 7500798 A SE7500798 A SE 7500798A SE 7500798 L SE7500798 L SE 7500798L
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- dimethyl
- group
- ethyl
- oxo
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000001589 carboacyl group Chemical group 0.000 abstract 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 2
- 239000005977 Ethylene Substances 0.000 abstract 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 2
- BGTOWKSIORTVQH-HOSYLAQJSA-N cyclopentanone Chemical class O=[13C]1CCCC1 BGTOWKSIORTVQH-HOSYLAQJSA-N 0.000 abstract 2
- CVHCGPQMSHEEFH-UHFFFAOYSA-N ethyl 2-(2-phenylethyl)hexanoate Chemical compound CCCCC(C(=O)OCC)CCC1=CC=CC=C1 CVHCGPQMSHEEFH-UHFFFAOYSA-N 0.000 abstract 2
- WDAXFOBOLVPGLV-UHFFFAOYSA-N ethyl isobutyrate Chemical compound CCOC(=O)C(C)C WDAXFOBOLVPGLV-UHFFFAOYSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
- SQAMAZXFKNQCCJ-UHFFFAOYSA-M (2-oxo-3-phenoxypropyl)-triphenylphosphanium;chloride Chemical compound [Cl-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)CC(=O)COC1=CC=CC=C1 SQAMAZXFKNQCCJ-UHFFFAOYSA-M 0.000 abstract 1
- JZFURVKGBPLSDM-UHFFFAOYSA-M (4-ethoxy-2-oxobutyl)-triphenylphosphanium;chloride Chemical compound [Cl-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(CC(=O)CCOCC)C1=CC=CC=C1 JZFURVKGBPLSDM-UHFFFAOYSA-M 0.000 abstract 1
- JLIDRDJNLAWIKT-UHFFFAOYSA-N 1,2-dimethyl-3h-benzo[e]indole Chemical compound C1=CC=CC2=C(C(=C(C)N3)C)C3=CC=C21 JLIDRDJNLAWIKT-UHFFFAOYSA-N 0.000 abstract 1
- SHASLAUEJHRDFZ-UHFFFAOYSA-N 1-chloro-3-phenoxypropan-2-one Chemical compound ClCC(=O)COC1=CC=CC=C1 SHASLAUEJHRDFZ-UHFFFAOYSA-N 0.000 abstract 1
- IFRMRRXXJMQATO-UHFFFAOYSA-N 1-chloro-5-phenylpentan-2-one Chemical compound ClCC(=O)CCCC1=CC=CC=C1 IFRMRRXXJMQATO-UHFFFAOYSA-N 0.000 abstract 1
- MGTGUEKJBFTQQW-UHFFFAOYSA-N 1-chloropentan-2-one Chemical compound CCCC(=O)CCl MGTGUEKJBFTQQW-UHFFFAOYSA-N 0.000 abstract 1
- FTZNMXSYERMMBC-UHFFFAOYSA-N 1-cyclohexyl-2-dimethoxyphosphorylethanone Chemical compound COP(=O)(OC)CC(=O)C1CCCCC1 FTZNMXSYERMMBC-UHFFFAOYSA-N 0.000 abstract 1
- ZBWUIIVBQKDTEF-UHFFFAOYSA-N 1-dimethoxyphosphoryl-3-(2-phenylethyl)heptan-2-one Chemical compound COP(=O)(OC)CC(=O)C(CCCC)CCC1=CC=CC=C1 ZBWUIIVBQKDTEF-UHFFFAOYSA-N 0.000 abstract 1
- BIIUEEHQYBFXTP-UHFFFAOYSA-N 1-dimethoxyphosphoryl-3-methylbutan-2-one Chemical compound COP(=O)(OC)CC(=O)C(C)C BIIUEEHQYBFXTP-UHFFFAOYSA-N 0.000 abstract 1
- HQJAUSGLWRLGOI-UHFFFAOYSA-N 1-dimethoxyphosphoryl-3-phenylpropan-2-one Chemical compound COP(=O)(OC)CC(=O)CC1=CC=CC=C1 HQJAUSGLWRLGOI-UHFFFAOYSA-N 0.000 abstract 1
- ONYIBVIIOCEBIV-UHFFFAOYSA-N 1-dimethoxyphosphoryl-4-phenylbutan-2-one Chemical compound COP(=O)(OC)CC(=O)CCC1=CC=CC=C1 ONYIBVIIOCEBIV-UHFFFAOYSA-N 0.000 abstract 1
- ZGDFXYHVIFUFEX-UHFFFAOYSA-N 1-phenoxy-3-(triphenyl-$l^{5}-phosphanylidene)propan-2-one Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(C=1C=CC=CC=1)=CC(=O)COC1=CC=CC=C1 ZGDFXYHVIFUFEX-UHFFFAOYSA-N 0.000 abstract 1
- VVPGZDLUXOOSQN-UHFFFAOYSA-M 2-oxopentyl(triphenyl)phosphanium;chloride Chemical compound [Cl-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(CC(=O)CCC)C1=CC=CC=C1 VVPGZDLUXOOSQN-UHFFFAOYSA-M 0.000 abstract 1
- -1 3 - Ethoxypropionyl Chemical group 0.000 abstract 1
- ZJVJFVYJWJKOOL-UHFFFAOYSA-N 5-phenyl-1-(triphenyl-$l^{5}-phosphanylidene)pentan-2-one Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(C=1C=CC=CC=1)=CC(=O)CCCC1=CC=CC=C1 ZJVJFVYJWJKOOL-UHFFFAOYSA-N 0.000 abstract 1
- JAGZUIGGHGTFHO-UHFFFAOYSA-N Ethyl 3-phenylpropanoate Chemical compound CCOC(=O)CCC1=CC=CC=C1 JAGZUIGGHGTFHO-UHFFFAOYSA-N 0.000 abstract 1
- XQZQQTKQDOZGFR-UHFFFAOYSA-M [Cl-].C1(=CC=CC=C1)CCCCC(=O)[P+](C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1 Chemical compound [Cl-].C1(=CC=CC=C1)CCCCC(=O)[P+](C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1 XQZQQTKQDOZGFR-UHFFFAOYSA-M 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- DULCUDSUACXJJC-UHFFFAOYSA-N benzeneacetic acid ethyl ester Natural products CCOC(=O)CC1=CC=CC=C1 DULCUDSUACXJJC-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 150000001940 cyclopentanes Chemical class 0.000 abstract 1
- VONWDASPFIQPDY-UHFFFAOYSA-N dimethyl methylphosphonate Chemical compound COP(C)(=O)OC VONWDASPFIQPDY-UHFFFAOYSA-N 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- JJOYCHKVKWDMEA-UHFFFAOYSA-N ethyl cyclohexanecarboxylate Chemical compound CCOC(=O)C1CCCCC1 JJOYCHKVKWDMEA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008016 pharmaceutical coating Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB373074A GB1468830A (en) | 1974-01-26 | 1974-01-26 | Cyclopentane derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7500798L true SE7500798L (ja) | 1975-07-28 |
| SE421614B SE421614B (sv) | 1982-01-18 |
Family
ID=9763869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7500798A SE421614B (sv) | 1974-01-26 | 1975-01-24 | Forfarande for framstellning av vissa terapeutiskt aktiva 9-oxo-1-prostanoler |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4088695A (ja) |
| JP (1) | JPS5817747B2 (ja) |
| AU (1) | AU498990B2 (ja) |
| BE (1) | BE824773A (ja) |
| CA (1) | CA1055488A (ja) |
| CH (1) | CH609664A5 (ja) |
| CS (1) | CS189682B2 (ja) |
| CY (1) | CY1058A (ja) |
| DE (1) | DE2502919C2 (ja) |
| DK (1) | DK23075A (ja) |
| FI (1) | FI750196A (ja) |
| FR (1) | FR2258845B1 (ja) |
| GB (1) | GB1468830A (ja) |
| HK (1) | HK48380A (ja) |
| HU (1) | HU172827B (ja) |
| IE (1) | IE40571B1 (ja) |
| LU (1) | LU71716A1 (ja) |
| NL (1) | NL183399B (ja) |
| SE (1) | SE421614B (ja) |
| ZA (1) | ZA75518B (ja) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7605381A (nl) * | 1975-05-26 | 1976-11-30 | Schering Ag | Werkwijze voor het bereiden van prostaanderi- vaten en werkwijze voor het bereiden van een geneesmiddel met prostaglandinewerking. |
| DE2715838A1 (de) * | 1977-04-05 | 1978-10-19 | Schering Ag | Neue prostanderivate und verfahren zu ihrer herstellung |
| GB1581886A (en) * | 1977-05-26 | 1980-12-31 | May & Baker Ltd | Prostanol derivatives |
| JPH085794B2 (ja) * | 1989-07-27 | 1996-01-24 | 株式会社上野製薬応用研究所 | 高脂質血症処置・血中脂質成分低下剤 |
| JPH0769897A (ja) * | 1993-09-01 | 1995-03-14 | Green Cross Corp:The | 血中トリグリセリド低下作用剤 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1451798A (en) * | 1973-08-02 | 1976-10-06 | Ici Ltd | Prostanoic acid derivatives |
-
1974
- 1974-01-26 GB GB373074A patent/GB1468830A/en not_active Expired
-
1975
- 1975-01-23 US US05/543,552 patent/US4088695A/en not_active Expired - Lifetime
- 1975-01-24 LU LU71716*A patent/LU71716A1/xx unknown
- 1975-01-24 AU AU77621/75A patent/AU498990B2/en not_active Expired
- 1975-01-24 CY CY1058A patent/CY1058A/xx unknown
- 1975-01-24 IE IE136/75A patent/IE40571B1/xx unknown
- 1975-01-24 FI FI750196A patent/FI750196A/fi not_active Application Discontinuation
- 1975-01-24 DE DE2502919A patent/DE2502919C2/de not_active Expired
- 1975-01-24 BE BE152706A patent/BE824773A/xx unknown
- 1975-01-24 FR FR7502258A patent/FR2258845B1/fr not_active Expired
- 1975-01-24 NL NLAANVRAGE7500868,A patent/NL183399B/xx not_active IP Right Cessation
- 1975-01-24 JP JP50009912A patent/JPS5817747B2/ja not_active Expired
- 1975-01-24 CA CA218,602A patent/CA1055488A/en not_active Expired
- 1975-01-24 HU HU75MA00002644A patent/HU172827B/hu not_active IP Right Cessation
- 1975-01-24 DK DK23075*BA patent/DK23075A/da not_active Application Discontinuation
- 1975-01-24 SE SE7500798A patent/SE421614B/xx not_active IP Right Cessation
- 1975-01-24 CS CS75507A patent/CS189682B2/cs unknown
- 1975-01-24 CH CH85475A patent/CH609664A5/xx not_active IP Right Cessation
- 1975-01-24 ZA ZA00750518A patent/ZA75518B/xx unknown
-
1980
- 1980-08-28 HK HK483/80A patent/HK48380A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CS189682B2 (en) | 1979-04-30 |
| NL183399B (nl) | 1988-05-16 |
| FI750196A (ja) | 1975-07-27 |
| US4088695A (en) | 1978-05-09 |
| BE824773A (fr) | 1975-07-24 |
| JPS50106941A (ja) | 1975-08-22 |
| CY1058A (en) | 1980-08-01 |
| CA1055488A (en) | 1979-05-29 |
| JPS5817747B2 (ja) | 1983-04-09 |
| FR2258845A1 (ja) | 1975-08-22 |
| AU498990B2 (en) | 1979-03-29 |
| ZA75518B (en) | 1976-01-28 |
| IE40571L (en) | 1975-07-26 |
| HU172827B (hu) | 1978-12-28 |
| LU71716A1 (ja) | 1975-12-09 |
| FR2258845B1 (ja) | 1980-01-25 |
| GB1468830A (en) | 1977-03-30 |
| DK23075A (ja) | 1975-09-15 |
| DE2502919C2 (de) | 1985-06-27 |
| CH609664A5 (ja) | 1979-03-15 |
| DE2502919A1 (de) | 1975-07-31 |
| HK48380A (en) | 1980-09-05 |
| NL7500868A (nl) | 1975-07-29 |
| IE40571B1 (en) | 1979-07-04 |
| AU7762175A (en) | 1976-07-29 |
| SE421614B (sv) | 1982-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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