SE522511C2 - System for dental filling material or implant material consists of water-based hydration liquid and powdered material comprising water-soluble phosphate or phase - Google Patents

Abstract

A system for dental filling material or implant (1) material, consists of water based hydration liquid and powdered material. The binder phase of powdered material consists of calcium-based cement system. The powdered material and/or hydration liquid comprises water-soluble phosphate or phase. The system forms apatite during hydration. A system for dental filling material or implant material and for bonding dental filling material or implant material between tooth and bone, respectively, consists of water-based hydration liquid and powdered material. The binder phase of powdered material consists of calcium based cement system. The powdered material is saturated with liquid, which is reacted with binder phase to hydrate chemically bonded ceramic material. The powdered material and/or hydration liquid comprises water-soluble phosphate or phase which forms water-soluble phosphate. The system forms apatite during hydration. Independent claims are also included for the following: (1) powdered material; (2) aqueous hydration liquid for powdered material; (3) implant material comprising substrate; and (4) method for achieving bonding dental filling material and implant material between tooth and bone, respectively.

Description

DESCRIPTION OF THE INVENTION The present invention aims to provide a system for producing a chemically bonded ceramic material from a powder material whose binder phase consists mainly of: -: - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - a calcium-based cement system, which system exhibits the ability to form apatite in-situ.

By ability to form apatite in-situ is meant here that the system includes necessary constituents for the formation of apatite, e.g. hydroxyapatite or orurapatite (Ca5 (PO4) 3OH and Ca5 (PO4) 3F respectively) and any other biologically beneficial phase, and that the system allows such phases to be formed during and / or after the hydration reaction. This achieves at least the advantage that apatite does not need to be added as a separate additive. The formed material can be said to constitute a chemically bonded ceramic composite.

The fact that apatite is formed in the material is a sign that the material is bioactive and interacts with the body. The distribution of apatite also becomes homogeneous in the material, even in contact zones with biological material, bone and tooth tissue. The fact that apatite is formed in such contact zones is particularly favorable for binding. Another advantage of apatite formation is that the environment is alkaline. Since apatite is a body-specific substance, the bonding system will provide excellent bonding properties with a very close connection between the dental filling / implant material and the tooth / bone. The integration with environments with apatite content is very important, especially for dental filling materials, orthopedic masses and materials such as layers on implants. The latter refers to in-situ prepared surface layers of chemically bonded ceramic composite based on apatite which have a great effect on bone integration.

According to the invention, a system for dental filling material or implant material, a powder material and a hydrating fluid are thus presented, according to the following patent claims.

The powder material The powder material consists of a calcium-containing basic ceramic powder of aluminates, silicates, phosphates, sulphates and combinations thereof, preferably aluminates. According to the invention, the powder material comprises water-soluble phosphate, whereby the cement system has the ability to form apatite during hydration.

Furthermore, it applies that: a. Said water-soluble phosphate may consist of a water-soluble phosphate-containing phase, eg alkali phosphates.

Effect: increase of the phosphate content of the material, gives a higher content of apatite (not only limited to the phosphate content of the solution), nous »10 15 20 25 30 35 Pl697 522 511 3 n: nu u The material may comprise sprouts of phosphate-containing phase, preferably hydroxy. and fl uorapatite, Effect: control of apatite precipitation, The material may comprise the addition of collagen, elastin or other high molecular weight proteins which are in-situ coated or pre-coated with apatite from saturated solution.

Effect: to control the precipitation of apatite, The material may include the addition of fluorine-containing phase of non-soluble nature, e.g. fl uoride-containing glass (glass ionomer glass) of a non-soluble nature, in contents of less than 10%. Other examples of or-fluorine-containing phase are calcium fluoride (CaF2) or sodium fluoride (NaF), i.e. fl uoride compounds that are soluble in water.

Effect: a way to get fl uor into the material whereby or uorapatite can form.

The material may include carbonate or biologically present ions which may form: oxalates, lactates, calcite, aragonite. For example, carbonate ions can form calcite and calcium can form insoluble biological salts with lactic anion, lactate, etc.

Effect: by controlling the concentration and composition of the ions, different biological phases containing Ca can be precipitated. Also applies to water-soluble additives in the powder raw material.

The powder material may be in the form of a crude body which preferably has a compact of at least 55% by volume of solid phase, more preferably at least 60% by volume of solid phase, most preferably at least 65% by volume of solid phase and most preferably at least 70% by volume. Alternatively, the powder material may be in the loose powder form, whereby it is mixed with the hydration liquid to a sludge which is then drained and compacted.

It is especially preferred that the main binder phase of the cement system consists of calcium aluminate (Ca-aluminate), since: 1. 2.

Ca-aluminates provide an alkaline environment for apatite, which makes this phase stable (not dissolution, obstacles to plaque formation and lactic acid formation) Ca-aluminate is present in excess and is formed in all pores in the material - contributes to filling in the material - if only apatite should is used, too little water is converted so that water-filled porosity can be filled with hydrate.

Ca-aluminate precipitates by acid-base reaction, where water reacts with the powder material, which begins to dissolve. The solution contains all the building blocks needed to form both calcium aluminate hydrate, gibbsite and apatite (if phosphorus is added in some form) and any other biologically favorable phase (calcite, aragonite, lactate rføso 10 15 20 25 30 35 P1697 522 511 4 etc). When the solubility product for each substance is reached, precipitation begins. The precipitation takes place everywhere, including in the micro-spaces between the filling material and the tooth wall. Small crystals precipitate in the surface topography of the tooth wall or other biological contact surface and contribute to the contact zone filling material-tooth / bone disappearing completely, meaning microstructural integration. In constellations up to 20,000 times, no gap can be detected.

In summary: Ca-aluminate is beneficial in the presence of apatite to a. B.

Protect the appetite from chemical dissolution at low pH, Ensure that a dense product is present / formed. (The pump in the system is Ca, aluminate and OH ions). Other added ions such as phosphates, fluorides, carbonates, etc. provide a secondary complementary purely biological phase. Contribute to the formation of a completely dense contact zone (microstructural integration) The hydration fluid form apatite.

Furthermore, a) b) d) said water-soluble phosphate forms phosphate ions in the liquid, preferably PO43 ', HPOf, H2PO4' or other phosphorus-containing ion.

The liquid may comprise carbonate ions or biologically present ions which may form: oxalates, lactates, calcite, aragonite. For example, carbonate ions can form calcite and calcium can form insoluble biological salts with lactic anion, lactate, etc.

Effect: by controlling the concentration and composition of the ions, various biological phases containing Ca can be precipitated. Concentration of phosphate ions should be 0.01- 5 M, preferably 0.1-2 M, most preferably 0.5- 1.5 M.

Effect: High concentration gives more apatite phase, pH should be adjusted to at least 7, preferably 7-12.5 and even more preferably 7-11, Effect: pH controls equilibrium for precipitation of apatite and katoite (main phase in the Ca-aluminate hydrate system at body temperature ), Isaac 10 15 P1697 522 511 5 a <øøo ue) The liquid may comprise addition of fl uoride ions to a concentration fl uoride ions in the range 0.01-5 M, preferably O. 1-2 M, most preferably 0.5-1 M, Effect: provides training of fl uorapatite along with katoit. (Fluoroapatite is even more stable than hydroxyapatite), f) The liquid may include accelerator and / or liquid reducing agent.

The invention is not limited to the preferred embodiments but can be varied within the claims. In particular, it should be understood that other aspects of the system / powder material / hydration fluid follow that described in SE 463 493, SE 502 987, WO 00/21489, WO 01/76534, WO 01/76535, SE-AO-0103189-7 or SE-A0-0103190-5, which aspects are hereby incorporated by reference. It is further to be understood that the powder material or the hydrating liquid can be used in combination but also separately and then together with conventional hydrating liquids and powder material, e.g. those described in the just mentioned older patent applications.

Claims (1)

A system for dental filling material or implant material, comprising an aqueous hydration fluid and a powder material whose binder phase consists mainly of a calcium-based cement system, which powder material has the ability to, after soaking with the hydrate the hydrating liquid reacting with the binder phase to a chemically bonded ceramic material, characterized in that said powder material and / or said hydrating liquid comprise water-soluble phosphate, whereby the system exhibits the ability to form apatite during the hydration. System according to claim 1, characterized in that the system exhibits the ability to form 0.01-30% by volume of apatite in the system during hydration. System according to claim 1 or 2, characterized in that the system has a pH of at least 7, preferably 7-12.5 and even more preferably 7-1 1, preferably by using buffer systems of e.g. phosphates or carbonates. Powder material whose binder phase consists mainly of a calcium-based cement system, which powder material has the ability to hydrate a soak with a binder phase-reactive hydration liquid to a chemically bonded ceramic material, characterized in that the powder material comprises a water-soluble system. exhibits the ability to form apatite during hydration. Powder material according to Claim 4, characterized in that the cement system has the ability to form 0.01-30% by volume of apatite in the cement system during hydration. Powder material according to any one of claims 4-5, characterized in that said calcium-based cement system consists of a cement system in the group consisting of aluminates, silicates, phosphates, sulphates and combinations thereof, preferably aluminates. Powder material according to any one of claims 4-6, characterized in that said water-soluble phosphate consists of an alkali phosphate. -v- u. .- 10 15 20 25 30 35 PI697 8. 10. 11. 12. 13. 14 15. 522 511 v Powder material according to any one of claims 4-7, characterized in that it also comprises sprouts of phosphate-containing phase, preferably hydroxy- or orurapatite. Powder material according to any one of claims 4-8, characterized in that it also comprises high molecular weight proteins, preferably collagen or elastin. Powder material according to any one of claims 4-9, characterized in that it also comprises a non-soluble phase of a non-soluble nature, preferably in contents of from 0.5% and up to 10%. Powder material according to any one of claims 4-10, characterized in that it comprises carbonate or biologically present ions which have the ability to form calcite and / or aragonite, oxalates, lactates, citrates. Powder material according to any one of claims 4-11, characterized in that it is in the form of a crude body which preferably has a compact degree of at least 55% by volume of solid phase, even more preferably at least 60% by volume of solid phase, most preferably at least 65% by volume solid phase and most preferably at least 70% by volume solid phase. Aqueous hydrating liquid for a powder material whose binder phase consists mainly of a calcium-based cement system, which powder material exhibits the ability to hydrate after soaking with the binder phase-reactive hydration liquid to a chemically bonded ceramic material, characterized in that the hydrating liquid exhibits the ability to form apatite during hydration. Hydration fluid according to claim 13, characterized in that said water-soluble phosphate is present in an amount of at least 0.01-5 M, preferably 0.1-2 M and even more preferably 0.5-1.5 M. Hydration fluid according to any one of Claims 13-14, characterized in that said water-soluble phosphate comprises phosphate ions in the group consisting of PO43 ', HPOÛ, H2POJ, ammonium hydrogen phosphate and other phosphorus-containing ions. 1:11 »10 15 v | | Hydration fluid according to any one of claims 13-15, characterized in that it has a pH of at least 7, preferably 7-12.5 and even more preferably 7-11, preferably by using buffer systems of e.g. phosphates or carbonates. Hydrating fluid according to any one of claims 13-16, characterized in that it comprises carbonate ions or biologically present ions which have the ability to form calcite and / or aragonite, oxalates, lactates, citrates. Hydration fluid according to any one of claims 13-17, characterized in that it comprises fluride ions, preferably at a level of 0.01-5 M, even more preferably O. 1-2 M and most preferably O.5-1 M. 19. Hydration fluid according to any one of claims 13-18, characterized in that it comprises an accelerator and / or a fluid reducing agent.