SE519020C2 - Method and apparatus for electronically controlled microprocessing, analysis and drug dosing - Google Patents
Method and apparatus for electronically controlled microprocessing, analysis and drug dosingInfo
- Publication number
- SE519020C2 SE519020C2 SE0100227A SE0100227A SE519020C2 SE 519020 C2 SE519020 C2 SE 519020C2 SE 0100227 A SE0100227 A SE 0100227A SE 0100227 A SE0100227 A SE 0100227A SE 519020 C2 SE519020 C2 SE 519020C2
- Authority
- SE
- Sweden
- Prior art keywords
- unit
- cannula
- skin portion
- skin
- analysis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150221—Valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150229—Pumps for assisting the blood sampling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150503—Single-ended needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150847—Communication to or from blood sampling device
- A61B5/150854—Communication to or from blood sampling device long distance, e.g. between patient's home and doctor's office
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/155—Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
- A61B5/0836—Measuring rate of CO2 production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Manufacturing & Machinery (AREA)
- Optics & Photonics (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
15 20 25 30 35 519 020 Fig 8 visar en funktionsprincip av anordningen med kanylen i provtagnings- och doseringsläge. Fig. 8 shows an operating principle of the device with the cannula in sampling and dosing position.
Fig 9 visar slutligen schematiskt en trådlös, elektroniskt styrd förbindelse mellan primärenheten, dvs den beskrivna analys- resp medicinska doseringsanordningen.Fig. 9 finally schematically shows a wireless, electronically controlled connection between the primary unit, ie the described analysis and medical dosing device.
För tydlighetens skull är beteckningama i första hand införda i fig 5 som har den största och tydligaste skalan, samt i fig 8 där funtionsdetaljema är förtydligande. 1 är en blodförande kroppsdel, t ex en öronsnibb, och 2 dess omslutande hud. 3 är ett en- eller dubbelsidigt häftande plåster, som dels är självfallet fäst vid det nämnda hudskiktet 2 och i andra fallet även vid anordningens bas 5. Ett steriliseringsfilter 4 är monterat mellan plåstret 3 och vulkattade basen 5. Basen 5:s översida är utformad till en kuggkrans 6 med kuggama på översidan. 7 är en kåpa som på insidan utgör moteringsfäste för vitala delar av anordningen och vars underdel genom ett antal uppslitsningar har gjorts fjädrande så att kåpan med glidytan 9 kan snäppas över kuggkransen och glidande gå in i spåret 12, och bilda ett glidlager mellan kåpan och basen.For the sake of clarity, the designations are primarily introduced in Fig. 5, which has the largest and clearest scale, and in Fig. 8, where the functional details are clarifying. 1 is a blood-bearing body part, such as an earlobe, and 2 its enveloping skin. 3 is a one-sided or double-sided adhesive patch, which is of course attached to the said skin layer 2 and in the other case also to the base 5 of the device. A sterilizing filter 4 is mounted between the patch 3 and the vulcanized base 5. The upper side of the base 5 is formed to a ring gear 6 with the teeth on the upper side. 7 is a cover which on the inside forms a mounting bracket for vital parts of the device and whose lower part has been made resilient by a number of slits so that the cover with the sliding surface 9 can be snapped over the ring gear and slidably enter the groove 12, forming a sliding layer between the cover and the base .
Dri vmotor 13 och kuggkrans 14 är visade i fig. 4 och även motor 15 för manövrering av punktionsdon. Punktionsdon 16 en småkalibn' g styv men elastisk stav, respektive rör som i stavform utför en multipelelektrod respektive i rörform utgör en mikrokanyl.Drive motor 13 and gear ring 14 are shown in Fig. 4 and also motor 15 for operating punctures. Puncture device 16 is a small-caliber rigid but elastic rod, respectively tubes which in rod form perform a multiple electrode and in tube form constitute a microcannula.
Funktionen framgår tydligast av fi g 8 där 16 i detta fall är en tunn och fjädrande kanyl med ändytan slipad till en spets så att inget material från sterliseringsfiltret 10 eller dess sidobegränsningar 11 kan stansas ut och komma in i patienten. Kanylen 16 är förenad med en genomsynli g analyssektion 17, som med en ävenledes genomsynlig klämbygel 19 är fast ansluten till den av dri vmotom 15 fram och återgående roterbara trumman 18. För analys finns en därtill anpassad belysningsanordning 20 och en inne i trumman monterad analysanordning 21. Utsignalen från analysanordningen 21 går via den böjliga ledningen 22 till en i fi g 4 antydd elektronikenhet 26 för bestämning av exempelvis blodcellsanalyser.The function is most clearly seen in Fig. 8, where in this case 16 is a thin and resilient cannula with the end surface ground to a tip so that no material from the sterilization filter 10 or its side restraints 11 can be punched out and enter the patient. The cannula 16 is connected to a transparent analysis section 17, which with a also transparent clamp 19 is fixedly connected to the drum 18 which can be rotated back and forth by the drive motor 15. For analysis there is a suitable lighting device 20 and an analysis device 21 mounted inside the drum. The output signal from the analysis device 21 goes via the flexible line 22 to an electronics unit 26 indicated in Fig. 4 for determining, for example, blood cell analyzes.
Analyssektionen 17 förenad med medikamentbehållaren 25 med den pumpbara slangen 23. Vätskan i slangen 23 kan pumpas i båda riktningama av slangpumpen 24, som är styrd av enheten 26. 27 är ett laddningsbart batteri för anordningens strömförsörjning. 28 är en styrning av kanylen med en urfräsning 29 för att hålla kanlen i ett fixerat läge och hindra den från att böjas på grund av moståndet den får vid genomgången av streriliseringsfiltret och huden.The assay section 17 connected to the medicament container 25 with the pumpable hose 23. The liquid in the hose 23 can be pumped in both directions by the hose pump 24, which is controlled by the unit 26. 27 is a rechargeable battery for the power supply of the device. 28 is a guide of the cannula with a cut-out 29 for holding the cannula in a fixed position and preventing it from bending due to the resistance it receives during the passage of the sterilization filter and the skin.
Den här beskrivna anordningen kan självfallet även utformas till separata anordningar för blodanalyser resp medicinering.The device described here can of course also be designed for separate devices for blood tests or medication.
I fi g 9 anges schematiskt det elektroniska stymingsflödet där 30 representerar patienten med apterad anordning 31 enligt uppfinningen. 32 utgör en eventuell kroppsburen relä- respektive analysenhet, 33 den evaluerande, sändande, instruktionsmottagande närdatorn samt 34 den av kvalificerad läkar- och sjukvårdspersonal styra centralfjärrdatom inom för respektive patientansvarig behandlingsklinik. 10 15 20 30 35 519 020 En modem trådlös hemvårdsdataelektronik relaterad till den enskilda patienten här markerad med 33a, kan funktionellt dessutom sammanlänkas med beskrivna anordning 31 i det i fi g 9 beskrivna koordinationssystemet. 35 representerar exempelvis en genom 31 samt 35a oximeter (mikro) och 35b C02 mirkosensor fysiologist styrd flödesregulator för styrning av 02 försäljningen 36.Fig. 9 schematically shows the electronic control flow where 30 represents the patient with fitted device 31 according to the invention. 32 constitutes a possible body-borne relay or analysis unit, 33 the evaluating, sending, instruction-receiving local computer and 34 the central remote computer controlled by qualified medical and medical staff within the respective treatment clinic for each patient. 515 20 30 35 519 020 A modem wireless home care data electronics related to the individual patient here marked with 33a, can additionally be functionally linked to described device 31 in the coordination system described in fig 9. 35 represents, for example, a flow regulator controlled by a through 31 and 35a oximeter (micro) and 35b CO 2 microsensor physiologist for controlling O2 sales 36.
Anordningen fästes på patienten med plåstret 3 på ett för respektive funktioner lämpligt hudområde (t. ex. på ena öronsnibbens baksida). Styrelektronik är anpassad att genomföra sina analys- respektive medicindoseringsfunktioner med förutbestämda tidsintervall och att rotera kåpan relativt basen i en förutbestämd vinkel mellan varje applicering. Detta för att genomföra punktionen med punktionsdonet inom ett ej punkterat hudområde.The device is attached to the patient with the patch 3 on a skin area suitable for each function (eg on the back of one earlobe). Control electronics are adapted to perform their analysis and drug dosing functions at predetermined time intervals and to rotate the cover relative to the base at a predetermined angle between each application. This is to perform the puncture with the puncture device within a non-punctured skin area.
Vridningsvinkeln kan lämpligen göras så stor att samma läge inte uppstår för varje varv av anordningen. Det steriliserande filtrets uppgift är att hålla kanylen steril och att vid varje punktion rensa kanylen från eventuella partikelrester som kan ha fastnat på punktionsdonet. För att säkerställa detta är sterilfiltrets skyddshinnor ll av ett elastiskt material som väl omsluter kanylen då den passerar.The angle of rotation can suitably be made so large that the same position does not occur for each revolution of the device. The task of the sterilizing filter is to keep the needle sterile and to clear the needle at each puncture of any particle residue that may have adhered to the puncture device. To ensure this, the protective membranes 11 of the sterile filter are made of an elastic material which well encloses the cannula as it passes.
Vid aktuell tidpunkt för provtagning respektive dosering roteras trumman 18 en viss vinkel så att punktionsdonet från sitt övre läge pressas nedåt genom steriliseringsfiltret och huden in i ett blodri kt område strax under huden. Slangpumpen 20 suger därefter in blod i analyssektionen 17. Blodet analyseras av anordningama 20 och 21 och utvärderas av enheten 26, som får slangpumpen 24 att ändra pumpriktning och pumpa tillbaka blodprovet och i förekommande fall injicera en av enheten 26 doserad medicin till patienten. Efter detta stannar pumpen och motor 15 drager tillbaka kanylen 16 till sitt utgångsläge. Härefter vrider motor 13 kåpan en förutbestämd vinkel och anordningen är redo för nästa provtagning respektive dosering. Ännu några närliggande utföringsforrner och därmed duplikationer enligt uppfinningen vid utrustningens aptering eventuellt vid insidan av handleden är artärpunktioner med ytterst tunnt punktionsdon för bodgasanalyser. Här sker val av punktionsorrirådet genom styming till lokalisation med största tryckvågs (puls) utslag genom inbyggnad av tryckgivare av känd typ i samma utrustning med minskad blodläckagerisk efter punktionsdonets retraktion.At the current time of sampling and dosing, the drum 18 is rotated a certain angle so that the puncture device from its upper position is pressed downwards through the sterilization filter and the skin into a blood-rich area just below the skin. The tubing pump 20 then sucks blood into the assay section 17. The blood is analyzed by the devices 20 and 21 and evaluated by the unit 26, which causes the tubing pump 24 to change pump direction and pump back the blood sample and, where appropriate, inject a drug dosed to the patient 26 into the patient. After this, the pump stops and motor 15 retracts the cannula 16 to its initial position. After this, motor 13 rotates the cover a predetermined angle and the device is ready for the next sampling and dosing, respectively. Still some adjacent embodiments and thus duplications according to the invention when fitting the equipment, possibly at the inside of the wrist, are artery punctures with extremely thin punctures for bodgas analyzes. Here, the puncture orbital area is selected by control to the location with the largest pressure wave (pulse) rash by incorporating pressure sensors of known type in the same equipment with reduced risk of blood leakage after the retraction of the puncture device.
Ytterligare en närliggande applikation med utnyttjande av uppfinningens princip utgör en "feedback" programmering av punktionsdonet till fömyad punktionsprocess, om och när den första punktionens analyssignaler indicera tveksamma signal värden.Another related application utilizing the principle of the invention is a "feedback" programming of the puncture device to the resumed puncture process, if and when the analysis signals of the first puncture indicate questionable signal values.
Claims (8)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0100227A SE519020C2 (en) | 2001-01-26 | 2001-01-26 | Method and apparatus for electronically controlled microprocessing, analysis and drug dosing |
PCT/SE2002/000156 WO2002058556A1 (en) | 2001-01-26 | 2002-01-28 | Method and apparatus for micro-sampling |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0100227A SE519020C2 (en) | 2001-01-26 | 2001-01-26 | Method and apparatus for electronically controlled microprocessing, analysis and drug dosing |
Publications (3)
Publication Number | Publication Date |
---|---|
SE0100227D0 SE0100227D0 (en) | 2001-01-26 |
SE0100227L SE0100227L (en) | 2002-07-27 |
SE519020C2 true SE519020C2 (en) | 2002-12-23 |
Family
ID=20282735
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0100227A SE519020C2 (en) | 2001-01-26 | 2001-01-26 | Method and apparatus for electronically controlled microprocessing, analysis and drug dosing |
Country Status (2)
Country | Link |
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SE (1) | SE519020C2 (en) |
WO (1) | WO2002058556A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2861282B1 (en) * | 2003-10-27 | 2007-07-06 | Patrice Richard | PLACENTAL BLOOD SAMPLING DEVICE. |
WO2015009970A1 (en) | 2013-07-18 | 2015-01-22 | Erythron Llc | Spectroscopic measurements with parallel array detector |
EP3111216A4 (en) | 2014-02-28 | 2017-11-22 | Nueon, Inc. | Method and apparatus for determining markers of health by analysis of blood |
EP3282937A4 (en) | 2015-04-14 | 2018-11-21 | Nueon Inc. | Method and apparatus for determining markers of health by analysis of blood |
EP3111976A1 (en) * | 2015-07-02 | 2017-01-04 | Cliniclab S.L. | Device for ejecting a hypodermic needle from a needle holder or syringe and corresponding blood sampling device |
WO2017165403A1 (en) | 2016-03-21 | 2017-09-28 | Nueon Inc. | Porous mesh spectrometry methods and apparatus |
WO2018085699A1 (en) | 2016-11-04 | 2018-05-11 | Nueon Inc. | Combination blood lancet and analyzer |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5759160A (en) * | 1995-11-20 | 1998-06-02 | Utah Medical Products, Inc. | Blood sampling system |
US5785662A (en) * | 1996-05-30 | 1998-07-28 | Medisys Technologies, Inc. | Blood collection assembly with plurality of vials |
-
2001
- 2001-01-26 SE SE0100227A patent/SE519020C2/en not_active IP Right Cessation
-
2002
- 2002-01-28 WO PCT/SE2002/000156 patent/WO2002058556A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
SE0100227L (en) | 2002-07-27 |
SE0100227D0 (en) | 2001-01-26 |
WO2002058556A8 (en) | 2004-04-15 |
WO2002058556A1 (en) | 2002-08-01 |
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NUG | Patent has lapsed |