SE514293C2 - Device for measuring concn. of specific materials in human tissue or organs - Google Patents

Device for measuring concn. of specific materials in human tissue or organs

Info

Publication number
SE514293C2
SE514293C2 SE9501688A SE9501688A SE514293C2 SE 514293 C2 SE514293 C2 SE 514293C2 SE 9501688 A SE9501688 A SE 9501688A SE 9501688 A SE9501688 A SE 9501688A SE 514293 C2 SE514293 C2 SE 514293C2
Authority
SE
Sweden
Prior art keywords
measuring
electrodes
electrode
isfet
concn
Prior art date
Application number
SE9501688A
Other languages
Swedish (sv)
Other versions
SE9501688D0 (en
SE9501688L (en
Inventor
Anders Essen-Moeller
Original Assignee
Synectics Medical Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synectics Medical Ab filed Critical Synectics Medical Ab
Priority to SE9501688A priority Critical patent/SE514293C2/en
Publication of SE9501688D0 publication Critical patent/SE9501688D0/en
Priority to SE9601204A priority patent/SE9601204D0/en
Publication of SE9501688L publication Critical patent/SE9501688L/en
Publication of SE514293C2 publication Critical patent/SE514293C2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333—Ion-selective electrodes or membranes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Engineering & Computer Science (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

Measuring the concn. of specific materials, e.g. for measuring pH, between two electrodes, uses a measuring electrode comprising \- 2 individual electrodes having different sensitivities to the concn. of the material being measured. The device used in this method is also claimed.

Description

514 295 2 Uppfinningen hänför sig vidare till en anordning enligt bifogade patentkrav 6. Anordningen utmárks speciellt av vad som anges i den kännetecknande delen hos sistnämnda patentkrav. The invention further relates to a device according to appended claims 6. The device is characterized in particular by what is stated in the characterizing part of the latter claim.

Nedan beskrivs uppfinningen närmare i anslutning till ut- föringsexempel samt bifogade ritning, där - fig. 1 schematiskt visar en första utföringsform av tvenne sammankopplade Isfet-elektroder samt - fig. 2 schematiskt visar en enkel Isfet-elektrod I fig. 1 betecknas med 1 en första elektrod av Isfet-typ sammankopplad med en ytterligare elektrod 2 av Isfet-typ.The invention is described in more detail below in connection with exemplary embodiments and the accompanying drawing, in which - Fig. 1 schematically shows a first embodiment of two interconnected Isfet electrodes and - Fig. 2 schematically shows a simple Isfet electrode In Fig. 1, 1 denotes first Isfet-type electrode connected to an additional Isfet-type electrode 2.

De båda elektroderna utbildar en pH-elektrod med en käns- lighet av ca 40 mV/pH-enhet.The two electrodes form a pH electrode with a sensitivity of about 40 mV / pH unit.

Med 3 betecknas en enkel elektrod av Isfet-typ , vilken normalt har en pH-känslighet av ca 50mV/pH-enhet. Enligt en utföringsform av en anordning enligt uppfinningen är de sammankopplade elektroderna 1, 2 å ena sidan och den enkla elektroden 3 å den andra sidan anordnade att utbilda ett elektrodpar i kontakt med ett mätobjekt, mellan vilka mät- ning är avsedd att ske, varvid en mâtelektrod 1, 2, 3 förefinns utbildad, vilken uppvisar en pH-känslighet av ca 10 mV/pH-enhet. Den sålunda ubildade mätelektroden 1, 2, 3 kräver ej någon referenselektrod, då skillnaden mellan de två pH-elektroderna 1, 2 resp. 3 med olika känslighet tillåter en absolutmätning av pH.3 denotes a simple electrode of the Isfet type, which normally has a pH sensitivity of about 50mV / pH unit. According to an embodiment of a device according to the invention, the interconnected electrodes 1, 2 on the one hand and the single electrode 3 on the other hand are arranged to form an electrode pair in contact with a measuring object, between which measurement is intended to take place, wherein a measuring electrodes 1, 2, 3 are formed, which have a pH sensitivity of about 10 mV / pH unit. The measuring electrode 1, 2, 3 thus formed does not require a reference electrode, as the difference between the two pH electrodes 1, 2 resp. 3 with different sensitivity allows an absolute measurement of pH.

De båda sammankopplade Isfet-elektroderna kan sammankopplas på annat sätt än vad som visas i fig. 1, varvid de olika sammankopplingarna uppvisar olika pH-känslighet. Sålunda uppvisar en S-D S-D-konfiguration en känslighet av ca 40 mV/pH-enhet och en S-D D-S-konfiguration en känslighet av ca 60 mV/pH-enhet. 514 293 3 Utföringsformer kan också tänkas, där en elektrod av Isfet- typ, enkel 3 eller multipel 1, 2, anbringas att utbilda ett elektrodpar med en annan typ av elektrod för utbildande av en mätelektrod för absolutmâtning så länge känsligheterna är olika. Vidare behöver elektroder av Isfet-typ ej an- vändas utan en mätelektrod kan utbildas medelst åtminstone tvenne elektroder av icke Isfet-typ så länge känsligheterna är olika.The two interconnected Isfet electrodes can be interconnected in a different way than that shown in Fig. 1, the different interconnections having different pH sensitivity. Thus, an S-D S-D configuration exhibits a sensitivity of about 40 mV / pH unit and an S-D D-S configuration has a sensitivity of about 60 mV / pH unit. 514 293 3 Embodiments are also conceivable, where an Isfet type electrode, single 3 or multiple 1, 2, is applied to form an electrode pair with another type of electrode to form a measuring electrode for absolute measurement as long as the sensitivities are different. Furthermore, Isfet-type electrodes do not need to be used, but a measuring electrode can be trained by means of at least two non-Isfet-type electrodes as long as the sensitivities are different.

Funktionen hos anordningen enligt uppfinningen liksom för- farandet enligt uppfinningen torde till väsentlig del fram- gått ovan. Genom att utbilda en mätelektrod medelst ett par av elektroder med olika känslighet kan absolutmätning av- seende skillnad mellan de båda elektroderna i paret åstad- kommas. Elektroderna i paret kan utgöras av en eller flera elektroder.The function of the device according to the invention as well as the method according to the invention should to a substantial extent appear above. By training a measuring electrode by means of a pair of electrodes with different sensitivity, absolute measurement regarding difference between the two electrodes in the pair can be achieved. The electrodes in the pair may be one or more electrodes.

Såsom torde framgått ovan erbjuder uppfinningen väsentliga fördelar jämfört med vad som är tidigare känt.As will be apparent above, the invention offers significant advantages over what is previously known.

Ovan har uppfinningen beskrivits i anslutning till ut- föringsexempel. Naturligtvis kan fler utföringsformer liksom mindre förändringar och kompletteringar tänkas utan att uppfinningstanken därför frángås.The invention has been described above in connection with exemplary embodiments. Of course, more embodiments as well as minor changes and additions are conceivable without departing from the spirit of the invention.

Sålunda kan mâtelektroder 1, 2, 3 med fler än tre elektro- der tänkas.Thus, measuring electrodes 1, 2, 3 with more than three electrodes are conceivable.

Vidare behöver mätelektroden ej vara avsedd för mätning av pH, utan mätning avseende andra ämnen/storheter kan tänkas.Furthermore, the measuring electrode does not have to be intended for measuring pH, but measurement for other substances / quantities is conceivable.

Sålunda kan nämnda vissa ämnen utgöras av exempelvis kalium, natrium, syre, koldioxid eller andra gaser, ammoniumjoner, kloridjoner eller ytterligare andra ämnen.Thus, said certain substances may consist of, for example, potassium, sodium, oxygen, carbon dioxide or other gases, ammonium ions, chloride ions or further other substances.

Enligt i vissa fall föredragna utföringsformer är en eller flera av de mätelektroden utbildande elektroderna jonsensi- tiva och/eller jonselektiva. 514 293 4 Uppfinningen skall således ej anses begränsad till ovan an- givna utföringsformer, utan kan varieras inom sin av bi- fogade patentkrav angivna ram.According to in some cases preferred embodiments, one or more of the electrodes forming the measuring electrode are ion-sensitive and / or ion-selective. Thus, the invention is not to be construed as limited to the embodiments set forth above, but may be varied within the scope of the appended claims.

Claims (4)

514295 Patentkrav514295 Claims 1. Förfarande för mätning av koncentration av vissa ämnen, exempelvis mätning av pH, innefattande mätning mellan tvenne elektroder, kânnetecknat av, att en mätelektrod (1, 2, 3) utbildas medelst två elektroder (1, 2, 3), vilka uppvisar olika känslighet för koncentrationen, som mätningen avser, varvid mätelektroden utbildas medelst jonselektiva elektroder varvid mätelektroden utbildas medelst en elektrod av Isfet-typ, varvid en elektrod utbildas medelst tvenne sammankopplade elektroder (1,2).A method for measuring the concentration of certain substances, for example measuring the pH, comprising measuring between two electrodes, characterized in that a measuring electrode (1, 2, 3) is formed by means of two electrodes (1, 2, 3), which have different sensitivity to the concentration to which the measurement relates, the measuring electrode being formed by means of ion-selective electrodes, the measuring electrode being formed by means of an Isfet-type electrode, the electrode being formed by means of two interconnected electrodes (1,2). 2. Anordning för mätning av koncentration av vissa ämnen, exempelvis mätning av pH, innefattande tvenne elektroder, mellan vilka mätning är avsedd att ske, kânnetecknad av en mätelektrod (1, 2, 3) innefattande tvenne elektroder (1, 2, 3), vilka uppvisar olika känslighet för koncentrationen, som mätningen avser varvid nämnda elektroder (1, 2, 3) är jonselektiva varvid en av nämnda elektroder är av Isfet-typ, varvid en av nämnda elektroder innefattar tvenne sammankopplade elektroder.Device for measuring the concentration of certain substances, for example measuring pH, comprising two electrodes, between which measurement is intended to take place, characterized by a measuring electrode (1, 2, 3) comprising two electrodes (1, 2, 3), which have different sensitivity to the concentration to which the measurement relates, said electrodes (1, 2, 3) being ion-selective, one of said electrodes being of the Isfet type, one of said electrodes comprising two interconnected electrodes. 3. Anordning enligt krav 2, kånnetecknad av att mätelektroden innefattar en elektrod av Isfet-typ respektive en av tvenne elektroder av Isfet-typ utbildad elektrod.Device according to claim 2, characterized in that the measuring electrode comprises an Isfet-type electrode and one electrode formed by two Isfet-type electrodes. 4. Anordning enligt krav 3, kânnetecknad av att mätelektroden är anordnad för mätning av pH.Device according to claim 3, characterized in that the measuring electrode is arranged for measuring pH.
SE9501688A 1995-05-05 1995-05-05 Device for measuring concn. of specific materials in human tissue or organs SE514293C2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SE9501688A SE514293C2 (en) 1995-05-05 1995-05-05 Device for measuring concn. of specific materials in human tissue or organs
SE9601204A SE9601204D0 (en) 1995-05-05 1996-03-28 Method and apparatus we concentration measurement

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9501688A SE514293C2 (en) 1995-05-05 1995-05-05 Device for measuring concn. of specific materials in human tissue or organs

Publications (3)

Publication Number Publication Date
SE9501688D0 SE9501688D0 (en) 1995-05-05
SE9501688L SE9501688L (en) 1996-11-06
SE514293C2 true SE514293C2 (en) 2001-02-05

Family

ID=20398221

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9501688A SE514293C2 (en) 1995-05-05 1995-05-05 Device for measuring concn. of specific materials in human tissue or organs

Country Status (1)

Country Link
SE (1) SE514293C2 (en)

Also Published As

Publication number Publication date
SE9501688D0 (en) 1995-05-05
SE9501688L (en) 1996-11-06

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