SE503432C2 - Omläggningsset - Google Patents

Abstract

A dressing set (1) comprising a non-occlusive backing (2), which backing (2) optionally has at least one adhesive side (4), a reservoir (3), which reservoir (3) in area is smaller than or at most equal to the backing (2) and which reservoir (3) comprises one or more layers and at least one pharmaceutically active compound, and optionally one or more peel strips, release papers (6) or similar arrangement protecting the reservoir (3) and/or the optional adhesive side (4) of said backing (2). A foil (5) having an area being larger than or at least equal to the area of the reservoir (3) is located between the reservoir (3) and the backing (2), which foil (5) consists of at least one hydrophilic or hydrophilized polymer. The foil (5) is in a dry, moisture-free state substantially occlusive, and after moisture absorption substantially non-occlusive.

Description

= >> <503 432 A significant problem with the storage and use of the transfer kit comprising a drug-containing depot, usually in the form of a compress, a matrix or the like, is migration or other leakage to and / or through the carrier whereby the active substance content in the depot decreases, with associated shortened storage time and too low medication level. Furthermore, in such cases the carrier and / or the package will be drug-containing. Adverse interaction of the chemical and / or physical reactions between the active substance (s) and the carrier may also occur. In addition to the problems that a reduced content of active substance and / or shortened storage time can give rise to in the form of incorrect and / or too low medication or incorrect special treatment, a drug-containing carrier or packaging entails undesirable health risks for the persons who handle them. Migration or other leakage can be difficult to detect, unless the active substance gives rise to discoloration and the like. Discoloration can in turn give rise to problems of a cosmetic and / or psychological nature.

A solution to the above problem is a conversion set comprising a completely dense, occlusive, carrier material. However, in many cases this is completely unacceptable from a medical point of view, especially in the case of such special treatment which requires non-occlusion of the product. An occlusive carrier blocks the wound or medication site from air access and provides increased fluid content in the underlying skin, which in turn leads to, among other things, difficult uptake of the medically active substance or substances and gives rise to maceration, tissue dissolution.

It is also known to manufacture a conversion set or the like comprising an occlusive, inert to the active medicinal substance or substances, barrier placed in, for example, a pocket between the drug-containing depot and the non-occlusive carrier of the conversion set. In these cases, the barrier is removed immediately before application, whereby a non-occlusive conversion set is obtained. This solution to the above-mentioned problems entails certain disadvantages such as a complicated manufacturing process, sticking of depot or carrier and barrier with difficulty in removing the barrier, risk of the depot coming loose and accompanying the barrier when it is removed and unnecessary handling of the conversion set in in connection with the removal of the barrier, which in itself can lead to medical risks and disadvantages.

Through the present invention, a conversion set primarily intended for special treatment but also for the uptake of drugs via the skin and / or similar medical applications has been achieved, which conversion set completely unexpectedly solves the above-related problems. The rearrangement set mainly comprises a non-occlusive and on its application side preferably adhesive carrier and a compress, matrix or similar depot built up of one or more layers and containing at least one medically active substance and preferably one or more peelable protective strips, sheets or the like placed on top of the application side. Furthermore, the rearrangement set comprises a foil placed between the depot and the carrier, the surface of the foil at least corresponding to the surface of the depot. The film consists of at least one hydrophilic or hydrophilized polymer and in the anhydrous state is mainly occlusive and after absorption of water is non-occlusive.

The properties of the film, occlusivity in dry and unused condition, and placement means that it will act as a barrier against migration or other leakage to or through the carrier during the storage time of the conversion set, whereby the active substance content in the depot can be kept substantially constant, storage time extended and problems with too low a level of medication are reduced. When a conversion set, according to the present invention, comprising a hydrophilic film is applied, moisture, water, will be absorbed through or from the skin, the film transitioning to a non-occlusive state and a conversion set which in all its parts is non-occlusive is obtained. Furthermore, the foil / barrier means that the above-mentioned health risks for handling personnel as well as discoloration of the carrier during the storage time can be avoided or reduced.

The present invention also opens up possibilities to manufacture conversion sets for, for example, antiseptic and chemotherapeutic special treatment, which conversion sets can replace loose drug-containing compresses, especially where the drug without the occlusive foil / barrier during storage would migrate to and / or through, interact with , discoloration, etc. a non-occlusive carrier. By transferring the foil to a non-occlusive state after application of a conversion set, the property of complete non-occlusivity in all parts of the conversion set, which is important for special treatment, is also obtained. A conversion set significantly simplifies, compared to loose compresses, handling and application.

Most occlusive, medically acceptable and preferably non-stick materials, which materials are inert to the medically active substance or substances in the depot, can be used in the manufacture of the film. Suitable materials used in various embodiments are polymers of the hydrophilized polyurethane type, agar, agarose or various derivatives of any of these polymers.

In alternative embodiments, the film comprises at least one polymer consisting of crosslinked dextrin, starch, dextran, cellulose, polyvinyl alcohol, polyacrylamide, polyvinylpyrrolidone or a derivative of any of these polymers.

The folding set comprises, as mentioned above, preferably one or more peelable protective sheets, protective strips or the like, these being suitably made of, for example, a siliconized and medically acceptable polymer film or siliconized paper. The dressing set according to the invention can be used to advantage when the depot as a medically active substance contains antiseptic and / or chemotherapeutic preparations for wound treatment, such as cadexomeric iodine, framycetin, fusidic acid and / or derivatives thereof.

Suitable applications are also TDDS containing, for example, nitroglycerin, nicotine, scopolamine, estrogens or prostaglandins.

The present invention is further explained in connection with the accompanying Figures 1 and 2, wherein - Figure 1 shows in plan view seen from its application side an embodiment of a rearrangement set according to the invention comprising a foil and - Figure 2 shows seen in a side view the same embodiment of a rearrangement set as Figure 1.

The various parts that show Figures 1 and 2 are not completely scalable as the parts for increased clarity have been enlarged or reduced in relation to actual dimensions or in relation to each other. Any peelable protective sheets, protective strips, etc. are not shown in Figures 1 and 2.

FIGURE 1 shows, seen from the side 4 to be applied to a patient and in plan view, an embodiment of a rearrangement set 1 according to the invention. The folding set 1 comprises a non-occlusive carrier 2, which is adhesive on the side 4 facing the viewer, a depot 3 of the compress type, intended to contain one or more medically active substances and a foil 5. The foil 5 consists of a hydrophilized polyurethane and in the dry anhydrous state occlusive, the medicinal substance contained in the depot 3 being prevented from migrating into or interacting with the carrier 2. FIG. 2> FIGURE 2 shows schematically and seen from one side the same embodiment embodiment of a rearrangement set 1 as Figure 1 and comprises the same parts, i.e. a non-occlusive carrier 2 with an adhesive side 4, a drug-containing depot 3 and a foil 5 placed between the depot 3 and the carrier 2 consisting of hydrophilized polyurethane.

The invention is not limited to the embodiments shown as these can be varied within the scope of the invention as regards the structure of the rearrangement set as well as its shape and size.

Claims (8)

503 432 PATENT REQUIREMENTS Transposition set (1) primarily intended for special treatment, absorption of drugs via the skin and / or similar medical applications, which transposition set (1) mainly comprises a non-occlusive and on its application side (4) preferably adhesive carrier (2). ) and a compress, matrix or similar depot (3) made up of one or more layers and containing at least one medically active substance and preferably one or more peelable protective sheets, protective strips or similar features placed on top of the application side (4) a foil (5) whose surface at least corresponds to the surface of the depot (3) is placed between the depot (3) and the carrier (2), (b) the foil (5) consists of at least one hydrophilic or hydrophilized polymer, (C) the foil ( 5) in the anhydrous state is mainly occlusive and (d) the foil (5) after absorption of water is non-occlusive. The conversion set (1) according to claim 1, characterized in that the foil (5) consists of at least one hydrophilized polyurethane. The conversion set (1) according to claim 1, characterized in that the foil (5) consists of agar and / or agarose and / or at least one derivative of these polymers. The conversion set (1) according to any one of claims 1-3, characterized in that the foil (5) comprises at least one polymer consisting of cross-linked dextrin, starch, dextran, cellulose or a derivative thereof. / 503 432 The conversion set (1) according to any one of claims 1-4, characterized in that the film (5) comprises at least one polymer consisting of cross-linked polyvinyl alcohol, polyacrylamide, polyvinylpyrrolidone or a derivative thereof. The conversion set (1) according to any one of claims 1-5, characterized in that the conversion set (1) comprises at least one peelable protective sheet, protective strip or the like consisting of a siliconized medically acceptable polymer film or siliconized paper. Transformation kit (1) according to one of Claims 1 to 6, characterized in that the depot (3) contains, as a medically active substance, at least one antiseptic and / or chemotherapeutic preparation for special treatment, such as cadexomer iodine, framycetin, fusidic acid or a derivative thereof. . The conversion kit (1) according to any one of claims 1-6, characterized in that the conversion kit (1) is a TDDS and that the depot (3) as a medically active substance contains nitroglycerin, nicotine, scopolamine, estrogens or prostaglandins.