SE460258B - Prepn. for dissolving caries - Google Patents
Prepn. for dissolving cariesInfo
- Publication number
- SE460258B SE460258B SE8704832A SE8704832A SE460258B SE 460258 B SE460258 B SE 460258B SE 8704832 A SE8704832 A SE 8704832A SE 8704832 A SE8704832 A SE 8704832A SE 460258 B SE460258 B SE 460258B
- Authority
- SE
- Sweden
- Prior art keywords
- amino acids
- solution
- sodium
- component
- sodium hypochlorite
- Prior art date
Links
- 208000002925 dental caries Diseases 0.000 title claims description 11
- 150000001413 amino acids Chemical class 0.000 claims abstract description 16
- 239000005708 Sodium hypochlorite Substances 0.000 claims abstract description 13
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims abstract description 13
- 230000007935 neutral effect Effects 0.000 claims abstract description 7
- 159000000000 sodium salts Chemical class 0.000 claims abstract description 6
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims abstract description 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims abstract description 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims abstract description 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract description 3
- 235000001014 amino acid Nutrition 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 4
- 230000002378 acidificating effect Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- 235000013922 glutamic acid Nutrition 0.000 claims description 2
- 239000004220 glutamic acid Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 abstract description 3
- 150000001875 compounds Chemical class 0.000 abstract description 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 6
- 150000002894 organic compounds Chemical class 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000005660 chlorination reaction Methods 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- -1 amino compound Chemical class 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 230000016571 aggressive behavior Effects 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 210000000078 claw Anatomy 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
460 258 verkan med avseende till karies men med en begränsad aggressi- vitet gentemot slemhinnorna. 460 258 effect with respect to caries but with a limited aggression white against the mucous membranes.
Uppfinningens ändamål uppnås genom att utföra preparatet med de i patentkrav l angivna kännetecknen respektive genomföra förfarandet med de i patentkrav 5 angivna kännetecknen.The object of the invention is achieved by carrying out the preparation with the features specified in claim 1 and implement the method with the features stated in claim 5.
Dentin, tandsubstansen, innehåller aminosyror bundna till varandra i långa kedjor. En aminosyras sidokedja kan antingen vara neutral, ha en negativ eller en positiv nettoladdning. En blandning av tre N-klorerade, organiska föreningar, företrädes- vis aminosyror, där en är neutral, en har en negativ nettoladd- ning och den sista en positiv nettoladdning ger därför bättre resultat som kariesupplösande substans än användning av en sort av N-klorerad förening.Dentin, the tooth substance, contains amino acids bound to each other in long chains. An amino acid side chain can either be neutral, have a negative or a positive net charge. One mixture of three N-chlorinated organic compounds, preferably amino acids, where one is neutral, one has a negative net charge. and the last one a positive net charge therefore gives better results as a caries-dissolving substance than the use of a variety of N-chlorinated compound.
Grundidën är att tre kväve-innehållande föreningar med olika laddningstillstànd framställes och användes som preparat för tandbehandling och lösning av karies i blandning med Natrium- hypoklorit. De organiska föreningarna föreligger lämpligen i form av en sur, en neutral och en basisk aminosyra.The basic idea is to include three nitrogen-containing compounds various state of charge are prepared and used as preparations for dental treatment and solution of caries in admixture with Sodium hypochlorite. The organic compounds are suitably present in in the form of an acidic, a neutral and a basic amino acid.
Närmare bestämt består preparatet enligt uppfinningen dels av natriumhypoklorit, vilken som nämnts har starkt lösande verkan pà kariesangripen substans, och tre kväve-innehållande föreningar, vilka företrädesvis är aminosyror, som när de blan~ das med natriumhypokloriten N-kloreras och ger föreningar inne~ hållande en aktiv klor som under bibehållande av en karies- lösande egenskap ej uppvisar natriumhypokloritens aggressivitet tilljslemhinnor.More specifically, the preparation according to the invention consists partly of sodium hypochlorite, which as mentioned has strong solubility effect on caries-infested substance, and three nitrogen-containing compounds, which are preferably amino acids, as when mixed with the sodium hypochlorite N-chlorinated and gives compounds inside ~ maintaining an active chlorine which, while maintaining a caries dissolving property does not exhibit the aggressiveness of sodium hypochlorite mucous membranes.
Kloreringen av aminosyran eller den organiska föreningen innehållande en -NH-grupp sker med natriumhypoklorit vid pH ca ll med överskott av aminoföreningen. Reaktion mellan natrium- hypoklorit och aminoförening är mycket snabb. Den resulterande N-klorerade organiska föreningen är däremot icke stabil utan sönderdelas relativt snabbt.The chlorination of the amino acid or the organic compound containing an -NH- group takes place with sodium hypochlorite at pH approx ll with excess of the amino compound. Reaction between sodium hypochlorite and amino compound are very fast. The resulting The N-chlorinated organic compound, on the other hand, is not stable without decomposes relatively quickly.
Enligt uppfinningen föreslås därför att förfarandet för preparatets slutframställning anslutes till tandbehandlingen genom att blandningen av natriumbypoklorit och överskottet av organisk förening sker så nära den kariesangripna tand, vilken skall behandlas, som möjligt. Detta innebär att dessa' båda 469 258 substanser blandas nära spetsen pá den kanyl, som användes för insprutning av preparatet, dvs så nära kanylens utlopp som möj- ligt.According to the invention, it is therefore proposed that the method for the final preparation of the preparation is connected to the dental treatment by the mixture of sodium bypochlorite and the excess of organic compounding occurs so close to the caries-infested tooth, which shall be treated, as far as possible. This means that these 'both 469 258 substances are mixed near the tip of the cannula used for injection of the preparation, ie as close to the outlet of the needle as possible ligt.
För tandbchandlingen anordnas en insprutningsdysa i form av en kanyl. Kanylen uppvisar en utströmningsöppning, som är avsedd att riktas mot det område av en persons tanduppsättning som skall behandlas. Fram till utströmningsöppningen leder två kanaler- De båda kanalerna är anslutna till en tryckkälla för två vätskor, en för vardera kanalen. Dessa vätskor betecknas nedan med A och B.For the dental treatment, an injection nozzle in the form is arranged of a cannula. The cannula has an outflow opening, which is intended to target the area of a person's set of teeth to be treated. Two lead to the outflow opening channels- The two channels are connected to a pressure source for two liquids, one for each channel. These liquids are designated below with A and B.
Vätskorna skall föras in i respektive kanaler under sådant tryck, att man erhåller en för tandbehandlingen lämplig ut- strömningshastighet. Trycket kan åstadkommas antingen genom pumpar, som för vätskorna från behållare, eller genom att väts- korna tillföras från tryckbehàllare.The liquids must be introduced into the respective channels during such pressure, that one obtains a suitable for the dental treatment flow rate. The pressure can be achieved either by pumps, which carry the liquids from containers, or by the cows are supplied from pressure vessels.
Av de båda vätskorna är den ena en blandning av organiska föreningar, såsom angetts i det föregående, och denna vätska betecknas i det följande med A. Den andra vätskan är natrium- hypoklorit, såsonx även framgått av det föregående och denna vätska betecknas med B. När de båda vätskorna blandas vid ut- strömningsöppningen, där de båda kanalerna löper samman ger natriumhypokloriten en N-klorering av den organiska -NH-före- ningen, som tillföres i överskott, och strömmen av det karies- lösande preparatet enligt uppfinningen erhålles. Vid prepara- tets anströmning mot tandytan uppkommer den karieslösande effek- ten och don lösta, karíesangripande substansen bortföres av strömmen liksom andra ej önskvärda substanser pá tandytan såsom plaque.Of the two liquids, one is a mixture of organic compounds, as indicated above, and this liquid hereinafter referred to as A. The second liquid is sodium hypochlorite, såsonx also stated in the previous and this liquid is denoted by B. When the two liquids are mixed in the flow opening, where the two channels converge gives sodium hypochlorite an N-chlorination of the organic -NH-precursor the excess feed, and the flow of the caries dissolving preparation according to the invention is obtained. When preparing the influx of the tooth towards the tooth surface results in the caries-resolving effect tin and don dissolved, caries-infesting substance is removed by current as well as other undesirable substances on the tooth surface such as plaque.
Enligt uppfinningen sammansättes de båda vätskorna A och B på följande sätt: Grundsammansättninq fm Natriumsalten av en sur, en neutral och en basisk amino- « ~yra blandas i sådant förhållande att de efter klore- ü _, "inçen, beroende på olika reaktionshastigheter, 460 258 föreligger som N-klorerade derivat i förhållandet l:l:l.According to the invention, the two liquids A and B as follows: Basic composition fm The sodium salt of an acidic, a neutral and a basic amino acid « acid are mixed in such a proportion that after chlorination ü _, "incision, depending on different reaction rates, 460 258 exists as N-chlorinated derivatives in the ratio 1: 1: 1.
Totalkoncentrationen av aminosyrorna bör vara cirka 0,2 M. Lösningen bör dessutom innehålla så mycket natriumklo~ rid att blandningen med lösning B (se nedan) blir iso- tonisk och har ett pH av_cirka ll.The total concentration of the amino acids should be about 0.2 M. The solution should also contain as much sodium claw ~ that the mixture with solution B (see below) is isolated tonic and has a pH of about ll.
B.B.
Natriumhypokrorit cirka 0.014 M i vatten.Sodium hypochlorite about 0.014 M in water.
Om man förutsätter att A och B tillföres varandra vid ut- strömningsöppningen i per tidsenhet lika stora volym- mängder gäller ovanstående koncentrationer. Om volym- mängderna är olika måste proportionerna ändras i förhål- lande härtili. ' Exemgelz Lösning A kan vara en blandning' av natriumsalterna av glutaminsyra, Leucin och lysin med en totalkoncentration av cirka 0,2 M och ett pH av cirka ll.Assuming that A and B are added to each other at the flow opening in equal volumes per unit time. amounts apply to the above concentrations. About volume quantities are different, the proportions must be changed in lands here. ' Exemgelz Solution A may be a mixture of the sodium salts of glutamic acid, leucine and lysine with a total concentration of about 0.2 M and a pH of about 11.
Lösning B tillföres som angivits.Solution B is added as indicated.
Uli) 'a-'šUli) 'a-'š
Claims (5)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE89900339T DE3885304T2 (en) | 1987-12-01 | 1988-11-30 | PREPARATION FOR DENTAL TREATMENT AND METHOD FOR PRODUCTION. |
| PCT/SE1988/000652 WO1989005135A1 (en) | 1987-12-01 | 1988-11-30 | Preparation for dental treatment and method for production of the preparation |
| JP1500821A JP2728306B2 (en) | 1987-12-01 | 1988-11-30 | Preparation composition for dental treatment and method for preparing the preparation composition |
| AT89900339T ATE96303T1 (en) | 1987-12-01 | 1988-11-30 | PREPARATION FOR DENTAL TREATMENT AND METHOD OF MANUFACTURE. |
| EP89900339A EP0398893B1 (en) | 1987-12-01 | 1988-11-30 | Preparation for dental treatment and method for production of the preparation |
| FI902653A FI94023C (en) | 1987-12-01 | 1990-05-28 | Dental care product and preparation |
| NO902424A NO177691C (en) | 1987-12-01 | 1990-05-31 | Preparation for dental treatment and method for preparing the preparation |
| DK134990A DK134990D0 (en) | 1987-12-01 | 1990-05-31 | PREPARATION FOR DENTAL TREATMENT AND PROCEDURE FOR PREPARING THEREOF |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8703512A SE8703512D0 (en) | 1987-09-10 | 1987-09-10 | MENTALS FOR DENTAL TREATMENT |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8704832D0 SE8704832D0 (en) | 1987-12-01 |
| SE8704832L SE8704832L (en) | 1989-03-11 |
| SE460258B true SE460258B (en) | 1989-09-25 |
Family
ID=20369531
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8703512A SE8703512D0 (en) | 1987-09-10 | 1987-09-10 | MENTALS FOR DENTAL TREATMENT |
| SE8704832A SE460258B (en) | 1987-09-10 | 1987-12-01 | Prepn. for dissolving caries |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8703512A SE8703512D0 (en) | 1987-09-10 | 1987-09-10 | MENTALS FOR DENTAL TREATMENT |
Country Status (1)
| Country | Link |
|---|---|
| SE (2) | SE8703512D0 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998020838A1 (en) * | 1996-11-14 | 1998-05-22 | Medi Team Dentalutveckling i Göteborg AB | Preparation for dental treatment |
| US6572842B1 (en) * | 1999-01-19 | 2003-06-03 | Mediteam Dental, Ab | Preparation for dental treatment |
| US6582681B1 (en) * | 1998-08-17 | 2003-06-24 | Mediteam Dentalutveckling I Goteborg Ab | Method and a preparation for cleaning tooth root surfaces and surrounding tissue |
| US9642780B2 (en) | 2011-06-15 | 2017-05-09 | Rls Global Ab | Detection and removal of carious dentin tissue |
-
1987
- 1987-09-10 SE SE8703512A patent/SE8703512D0/en unknown
- 1987-12-01 SE SE8704832A patent/SE460258B/en not_active IP Right Cessation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998020838A1 (en) * | 1996-11-14 | 1998-05-22 | Medi Team Dentalutveckling i Göteborg AB | Preparation for dental treatment |
| US6582681B1 (en) * | 1998-08-17 | 2003-06-24 | Mediteam Dentalutveckling I Goteborg Ab | Method and a preparation for cleaning tooth root surfaces and surrounding tissue |
| US6572842B1 (en) * | 1999-01-19 | 2003-06-03 | Mediteam Dental, Ab | Preparation for dental treatment |
| US9642780B2 (en) | 2011-06-15 | 2017-05-09 | Rls Global Ab | Detection and removal of carious dentin tissue |
Also Published As
| Publication number | Publication date |
|---|---|
| SE8704832L (en) | 1989-03-11 |
| SE8704832D0 (en) | 1987-12-01 |
| SE8703512D0 (en) | 1987-09-10 |
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