SE428685B - Analogiforfarande for framstellning av cyanosubstituerade (3-lagalkylamino-2-acyl-0-propoxi)pyridiner - Google Patents

Analogiforfarande for framstellning av cyanosubstituerade (3-lagalkylamino-2-acyl-0-propoxi)pyridiner

Info

Publication number
SE428685B
SE428685B SE7706182A SE7706182A SE428685B SE 428685 B SE428685 B SE 428685B SE 7706182 A SE7706182 A SE 7706182A SE 7706182 A SE7706182 A SE 7706182A SE 428685 B SE428685 B SE 428685B
Authority
SE
Sweden
Prior art keywords
lagalkylamino
cyanos
pyridines
propoxy
acyl
Prior art date
Application number
SE7706182A
Other languages
English (en)
Swedish (sv)
Other versions
SE7706182L (sv
Inventor
J J Baldwin
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SE7706182L publication Critical patent/SE7706182L/xx
Publication of SE428685B publication Critical patent/SE428685B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
SE7706182A 1976-06-15 1977-05-26 Analogiforfarande for framstellning av cyanosubstituerade (3-lagalkylamino-2-acyl-0-propoxi)pyridiner SE428685B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/696,236 US4053605A (en) 1976-06-15 1976-06-15 Esterified-2(3-lower-alkyl-amino-propoxy)-3-cyano-pyridines and derivatives

Publications (2)

Publication Number Publication Date
SE7706182L SE7706182L (sv) 1977-12-16
SE428685B true SE428685B (sv) 1983-07-18

Family

ID=24796248

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7706182A SE428685B (sv) 1976-06-15 1977-05-26 Analogiforfarande for framstellning av cyanosubstituerade (3-lagalkylamino-2-acyl-0-propoxi)pyridiner

Country Status (9)

Country Link
US (3) US4053605A (da)
JP (1) JPS52153972A (da)
CH (1) CH632499A5 (da)
DE (1) DE2726754A1 (da)
DK (1) DK236477A (da)
FR (1) FR2355007A1 (da)
GB (1) GB1545708A (da)
NL (1) NL7705883A (da)
SE (1) SE428685B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000282A (en) * 1974-12-16 1976-12-28 Merck & Co., Inc. 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
US4279913A (en) * 1978-01-04 1981-07-21 Merck & Co., Inc. Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines
JPS54106476A (en) * 1978-01-04 1979-08-21 Merck & Co Inc Multiisubstituted 22*33lower alkylaminoo22 r100propoxy*pyridine
US4208416A (en) * 1978-06-27 1980-06-17 Merck & Co., Inc. N-Aralkyl containing cyanopyridines
DK267779A (da) * 1978-06-27 1979-12-28 Merck & Co Inc Fr&mgangsmaade til fremstilling af n-aralkylamino-propoxycyanopyridiner
US4175128A (en) * 1979-01-03 1979-11-20 Pfizer Inc. Method for treating congestive heart failure
US4393212A (en) * 1979-01-29 1983-07-12 Merck & Co., Inc. Certain nicotinic acid esters and corresponding nicotinonitriles
US4294969A (en) * 1979-01-29 1981-10-13 Merck & Co., Inc. Process for producing 2-bromo-3,5-disubstituted pyridines
DE2943774A1 (de) * 1979-10-26 1981-05-14 1000 Berlin Schering Ag Berlin Und Bergkamen Substituierte pyridine, verfahren zu ihrer herstellung und ihre verwendung
US4436740A (en) * 1982-07-26 1984-03-13 Merck & Co., Inc. 3-Cycloalkylamino-2-OR-propoxycyanopyridines
US4550117A (en) * 1982-07-26 1985-10-29 Merck & Co., Inc. 3-Cycloalkylamino-2-OR-propoxycyanopyridines, derivatives thereof, having anti-hypertensive activity
WO2015081384A1 (en) 2013-12-02 2015-06-11 The University Of Queensland Separator

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3946009A (en) * 1972-05-05 1976-03-23 Merck Sharp & Dohme (I.A.) Corporation 2-(3-Substituted amino-2-hydroxypropoxy)-3-substituted pyrazines
US4001327A (en) * 1972-07-05 1977-01-04 The Regents Of The University Of Michigan Novel quaternary salts and method
JPS5641637B2 (da) * 1973-11-26 1981-09-29
GB1449420A (en) * 1973-11-26 1976-09-15 Sankyo Co 7alpha-methoxycephalosporing derivatives
US4000282A (en) * 1974-12-16 1976-12-28 Merck & Co., Inc. 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
US4060601A (en) * 1976-06-15 1977-11-29 Merck & Co., Inc. Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines

Also Published As

Publication number Publication date
SE7706182L (sv) 1977-12-16
NL7705883A (nl) 1977-12-19
JPS52153972A (en) 1977-12-21
US4119630A (en) 1978-10-10
US4053605A (en) 1977-10-11
FR2355007A1 (fr) 1978-01-13
GB1545708A (en) 1979-05-10
FR2355007B1 (da) 1980-04-18
US4119721A (en) 1978-10-10
DE2726754A1 (de) 1977-12-29
DK236477A (da) 1977-12-16
CH632499A5 (de) 1982-10-15

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