SE330883B - - Google Patents
Info
- Publication number
- SE330883B SE330883B SE124667A SE124667A SE330883B SE 330883 B SE330883 B SE 330883B SE 124667 A SE124667 A SE 124667A SE 124667 A SE124667 A SE 124667A SE 330883 B SE330883 B SE 330883B
- Authority
- SE
- Sweden
- Prior art keywords
- group
- hydrogen atom
- carbon
- alpha
- hydroxyl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
1,172,273. Steroids. SCHERING A.G. 16 Jan., 1967 [29 Jan., 1966], No. 2136/67. Heading C2U. Novel compounds of the general formula in which R 1 represents a hydrogen atom, an alkyl group containing 1-4 carbon atoms or an acyl group of an organic carboxylic acid, R 2 represents a hydrogen atom or a hydroxyl group, Z represents a hydrogen atom or a methyl group, Y represents an alkyl or alkynyl group containing at least 3 carbon atoms which may be substituted or represents an ethynyl group, C 7 =C 8 represents a single or double carbon-carbon bond and #A represents the A- ring of a steroid nucleus and which may contain at least one additional substituent attached to the steroid nucleus that is inert towards a Grignard reagent of the formula YMgX in which X represents Cl, Br, or I, and in which the hydrogen atom in the 5-position, the methyl group in the 21-position and the OR 1 -substituent in the 22-position each has the α- or #- configuration, are obtained by treating the corresponding 6-keto-20-formyl compound of the pregnane series with a Grignard reagent of the formula YMgX, and in the resulting compound, if desired, selectively hydrogenating any unsaturated carbon-carbon bond present in the group represented by Y, and/or, if desired, saponifying any acyloxy group(s) and/or eliminating any ether group(s), or esterifying or etherifying any hydroxyl group(s) other than a 14α-hydroxyl group, and/or, if desired, when R 2 represents a hydrogen atom in the resulting compound, introducing by a known method a hydroxyl group in the 14α-position.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DESC038399 | 1966-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
SE330883B true SE330883B (en) | 1970-12-07 |
Family
ID=7434686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE124667A SE330883B (en) | 1966-01-29 | 1967-01-27 |
Country Status (12)
Country | Link |
---|---|
AT (1) | AT280491B (en) |
BE (1) | BE693275A (en) |
CH (1) | CH497404A (en) |
DE (1) | DE1593492A1 (en) |
DK (1) | DK114133B (en) |
ES (1) | ES336023A1 (en) |
FI (1) | FI43075B (en) |
FR (1) | FR1509563A (en) |
GB (1) | GB1172273A (en) |
IL (1) | IL27182A (en) |
NL (1) | NL6701321A (en) |
SE (1) | SE330883B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6486145B2 (en) | 1996-12-20 | 2002-11-26 | Novo Nordisk A/S | Meiosis regulating compounds |
-
1966
- 1966-01-29 DE DE19661593492 patent/DE1593492A1/en active Pending
- 1966-12-29 IL IL2718266A patent/IL27182A/en unknown
-
1967
- 1967-01-05 DK DK7167A patent/DK114133B/en unknown
- 1967-01-16 GB GB213667A patent/GB1172273A/en not_active Expired
- 1967-01-16 CH CH57267A patent/CH497404A/en not_active IP Right Cessation
- 1967-01-24 ES ES336023A patent/ES336023A1/en not_active Expired
- 1967-01-27 AT AT81067A patent/AT280491B/en not_active IP Right Cessation
- 1967-01-27 NL NL6701321A patent/NL6701321A/xx unknown
- 1967-01-27 FI FI24867A patent/FI43075B/fi active
- 1967-01-27 FR FR92777A patent/FR1509563A/en not_active Expired
- 1967-01-27 SE SE124667A patent/SE330883B/xx unknown
- 1967-01-27 BE BE693275D patent/BE693275A/xx unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6486145B2 (en) | 1996-12-20 | 2002-11-26 | Novo Nordisk A/S | Meiosis regulating compounds |
US6759400B2 (en) | 1996-12-20 | 2004-07-06 | Novo Nordisk A/S | Meiosis regulating compounds |
Also Published As
Publication number | Publication date |
---|---|
AT280491B (en) | 1970-04-10 |
DE1593492A1 (en) | 1970-07-16 |
GB1172273A (en) | 1969-11-26 |
DK114133B (en) | 1969-06-02 |
IL27182A (en) | 1971-01-28 |
BE693275A (en) | 1967-07-27 |
FR1509563A (en) | 1968-01-12 |
ES336023A1 (en) | 1968-02-16 |
NL6701321A (en) | 1967-07-31 |
FI43075B (en) | 1970-10-01 |
CH497404A (en) | 1970-10-15 |
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