SE308366B - - Google Patents

Info

Publication number
SE308366B
SE308366B SE52765A SE52765A SE308366B SE 308366 B SE308366 B SE 308366B SE 52765 A SE52765 A SE 52765A SE 52765 A SE52765 A SE 52765A SE 308366 B SE308366 B SE 308366B
Authority
SE
Sweden
Prior art keywords
caffeine
melt
cooled
granulate
coloured
Prior art date
Application number
SE52765A
Inventor
H Krahnefeld
Original Assignee
Dresden Arzneimittel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel
Publication of SE308366B publication Critical patent/SE308366B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Caffeine in the form of an abrasion-resistant non-coloured caffeine granulate is prepared by melting caffeine in the presence of a reducing agent which is inert to caffeine and which has completely left the caffeine by the time the melt has cooled, cooling the melt and grinding the cooled melt to give the desired granulate. Suitable reducing agents are hydrazine and formaldehyde.
SE52765A 1964-10-17 1965-01-15 SE308366B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD10710264 1964-10-17

Publications (1)

Publication Number Publication Date
SE308366B true SE308366B (en) 1969-02-10

Family

ID=5478303

Family Applications (1)

Application Number Title Priority Date Filing Date
SE52765A SE308366B (en) 1964-10-17 1965-01-15

Country Status (6)

Country Link
BE (1) BE660046A (en)
CH (1) CH485757A (en)
DE (1) DE1620656A1 (en)
GB (1) GB1088777A (en)
NL (1) NL6501358A (en)
SE (1) SE308366B (en)

Also Published As

Publication number Publication date
BE660046A (en) 1965-08-23
GB1088777A (en) 1967-10-25
NL6501358A (en) 1966-08-04
CH485757A (en) 1970-02-15
DE1620656A1 (en) 1970-07-16

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