SE308366B - - Google Patents
Info
- Publication number
- SE308366B SE308366B SE52765A SE52765A SE308366B SE 308366 B SE308366 B SE 308366B SE 52765 A SE52765 A SE 52765A SE 52765 A SE52765 A SE 52765A SE 308366 B SE308366 B SE 308366B
- Authority
- SE
- Sweden
- Prior art keywords
- caffeine
- melt
- cooled
- granulate
- coloured
- Prior art date
Links
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 abstract 10
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 abstract 5
- 229960001948 caffeine Drugs 0.000 abstract 5
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 abstract 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 2
- 239000008187 granular material Substances 0.000 abstract 2
- 239000000155 melt Substances 0.000 abstract 2
- 238000005299 abrasion Methods 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Caffeine in the form of an abrasion-resistant non-coloured caffeine granulate is prepared by melting caffeine in the presence of a reducing agent which is inert to caffeine and which has completely left the caffeine by the time the melt has cooled, cooling the melt and grinding the cooled melt to give the desired granulate. Suitable reducing agents are hydrazine and formaldehyde.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD10710264 | 1964-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE308366B true SE308366B (en) | 1969-02-10 |
Family
ID=5478303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE52765A SE308366B (en) | 1964-10-17 | 1965-01-15 |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE660046A (en) |
| CH (1) | CH485757A (en) |
| DE (1) | DE1620656A1 (en) |
| GB (1) | GB1088777A (en) |
| NL (1) | NL6501358A (en) |
| SE (1) | SE308366B (en) |
-
1965
- 1965-01-15 DE DE19651620656 patent/DE1620656A1/en active Pending
- 1965-01-15 SE SE52765A patent/SE308366B/xx unknown
- 1965-01-19 GB GB232265A patent/GB1088777A/en not_active Expired
- 1965-01-28 CH CH119165A patent/CH485757A/en not_active IP Right Cessation
- 1965-02-03 NL NL6501358A patent/NL6501358A/xx unknown
- 1965-02-22 BE BE660046A patent/BE660046A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE660046A (en) | 1965-08-23 |
| NL6501358A (en) | 1966-08-04 |
| GB1088777A (en) | 1967-10-25 |
| CH485757A (en) | 1970-02-15 |
| DE1620656A1 (en) | 1970-07-16 |
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