SE0401293D0 - Novel MS Reagents - Google Patents
Novel MS ReagentsInfo
- Publication number
- SE0401293D0 SE0401293D0 SE0401293A SE0401293A SE0401293D0 SE 0401293 D0 SE0401293 D0 SE 0401293D0 SE 0401293 A SE0401293 A SE 0401293A SE 0401293 A SE0401293 A SE 0401293A SE 0401293 D0 SE0401293 D0 SE 0401293D0
- Authority
- SE
- Sweden
- Prior art keywords
- reagents
- daltons
- heavy
- light
- methionine
- Prior art date
Links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
The invention provides reagents and kits for introducing a fixed charge to the side-chain of methionine, and peptides and proteins containing methionine, for selective identification by tandem mass spectrometry. The reagents are based on substituted acetophenones according to the following formula: The reagents of the present invention may also be used for differential quantitation of peptide concentrations between two different samples, by incorporation of stable isotope labels to the reagent, to yield a 'light' form (containing only natural isotopes), and a 'heavy' form by incorporating stable isotope labels into the substituent. These reagents give a mass difference of at least 8 Daltons and up to 13 Daltons between 'light' and 'heavy' reagents.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0401293A SE0401293D0 (en) | 2004-05-17 | 2004-05-17 | Novel MS Reagents |
PCT/SE2005/000677 WO2005110955A1 (en) | 2004-05-17 | 2005-05-10 | Substituted acetophenome as ms reagents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0401293A SE0401293D0 (en) | 2004-05-17 | 2004-05-17 | Novel MS Reagents |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0401293D0 true SE0401293D0 (en) | 2004-05-17 |
Family
ID=32501931
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0401293A SE0401293D0 (en) | 2004-05-17 | 2004-05-17 | Novel MS Reagents |
Country Status (2)
Country | Link |
---|---|
SE (1) | SE0401293D0 (en) |
WO (1) | WO2005110955A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9202678B2 (en) | 2008-11-14 | 2015-12-01 | Board Of Trustees Of Michigan State University | Ultrafast laser system for biological mass spectrometry |
CN105699580A (en) * | 2016-04-28 | 2016-06-22 | 河南大学 | Method for measuring organic acid content based on precolumn derivatization LC-MS |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003027682A2 (en) * | 2001-09-27 | 2003-04-03 | Purdue Research Foundation | Controlling isotope effects during fractionation of analytes |
AU2002952747A0 (en) * | 2002-11-18 | 2002-12-05 | Ludwig Institute For Cancer Research | Method for analysing peptides |
-
2004
- 2004-05-17 SE SE0401293A patent/SE0401293D0/en unknown
-
2005
- 2005-05-10 WO PCT/SE2005/000677 patent/WO2005110955A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2005110955A1 (en) | 2005-11-24 |
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SE0401293D0 (en) | Novel MS Reagents |