SE0401293D0 - Novel MS Reagents - Google Patents

Novel MS Reagents

Info

Publication number
SE0401293D0
SE0401293D0 SE0401293A SE0401293A SE0401293D0 SE 0401293 D0 SE0401293 D0 SE 0401293D0 SE 0401293 A SE0401293 A SE 0401293A SE 0401293 A SE0401293 A SE 0401293A SE 0401293 D0 SE0401293 D0 SE 0401293D0
Authority
SE
Sweden
Prior art keywords
reagents
daltons
heavy
light
methionine
Prior art date
Application number
SE0401293A
Other languages
Swedish (sv)
Inventor
Henrik Neu
Lee Olsen
Gavin E Reid
Kade D Roberts
Original Assignee
Amersham Biosciences Ab
Ludwig Inst Of Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Biosciences Ab, Ludwig Inst Of Cancer Res filed Critical Amersham Biosciences Ab
Priority to SE0401293A priority Critical patent/SE0401293D0/en
Publication of SE0401293D0 publication Critical patent/SE0401293D0/en
Priority to PCT/SE2005/000677 priority patent/WO2005110955A1/en

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

The invention provides reagents and kits for introducing a fixed charge to the side-chain of methionine, and peptides and proteins containing methionine, for selective identification by tandem mass spectrometry. The reagents are based on substituted acetophenones according to the following formula: The reagents of the present invention may also be used for differential quantitation of peptide concentrations between two different samples, by incorporation of stable isotope labels to the reagent, to yield a 'light' form (containing only natural isotopes), and a 'heavy' form by incorporating stable isotope labels into the substituent. These reagents give a mass difference of at least 8 Daltons and up to 13 Daltons between 'light' and 'heavy' reagents.
SE0401293A 2004-05-17 2004-05-17 Novel MS Reagents SE0401293D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SE0401293A SE0401293D0 (en) 2004-05-17 2004-05-17 Novel MS Reagents
PCT/SE2005/000677 WO2005110955A1 (en) 2004-05-17 2005-05-10 Substituted acetophenome as ms reagents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0401293A SE0401293D0 (en) 2004-05-17 2004-05-17 Novel MS Reagents

Publications (1)

Publication Number Publication Date
SE0401293D0 true SE0401293D0 (en) 2004-05-17

Family

ID=32501931

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0401293A SE0401293D0 (en) 2004-05-17 2004-05-17 Novel MS Reagents

Country Status (2)

Country Link
SE (1) SE0401293D0 (en)
WO (1) WO2005110955A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9202678B2 (en) 2008-11-14 2015-12-01 Board Of Trustees Of Michigan State University Ultrafast laser system for biological mass spectrometry
CN105699580A (en) * 2016-04-28 2016-06-22 河南大学 Method for measuring organic acid content based on precolumn derivatization LC-MS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003027682A2 (en) * 2001-09-27 2003-04-03 Purdue Research Foundation Controlling isotope effects during fractionation of analytes
AU2002952747A0 (en) * 2002-11-18 2002-12-05 Ludwig Institute For Cancer Research Method for analysing peptides

Also Published As

Publication number Publication date
WO2005110955A1 (en) 2005-11-24

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SE0401293D0 (en) Novel MS Reagents