SE0203552D0 - Thrombin concentration - Google Patents

Thrombin concentration

Info

Publication number
SE0203552D0
SE0203552D0 SE0203552A SE0203552A SE0203552D0 SE 0203552 D0 SE0203552 D0 SE 0203552D0 SE 0203552 A SE0203552 A SE 0203552A SE 0203552 A SE0203552 A SE 0203552A SE 0203552 D0 SE0203552 D0 SE 0203552D0
Authority
SE
Sweden
Prior art keywords
thrombin solution
thrombin
solution
relates
initial
Prior art date
Application number
SE0203552A
Other languages
Swedish (sv)
Inventor
Stefan Winge
Peter Aizawa
Original Assignee
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovitrum Ab filed Critical Biovitrum Ab
Priority to SE0203552A priority Critical patent/SE0203552D0/en
Publication of SE0203552D0 publication Critical patent/SE0203552D0/en
Priority to PCT/SE2003/001548 priority patent/WO2004050700A1/en
Priority to AU2003267906A priority patent/AU2003267906A1/en

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Surgery (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

One aspect of the invention relates to a process for the preparation of a concentrated thrombin solution from an initial thrombin solution obtainable by activation of a prothrombin solution, which process comprises subjecting such an initial thrombin solution to the following consecutive steps: (a) heat treatment and (b) hydrophobic interaction chromatography on an aliphatic adsorbent. Another aspect of the invention relates to a thrombin solution having a thrombin concentration higher than about 100,000 IU/ml. A further aspect of the invention relates to the use of a thrombin solution in a component for a fibrin glue.
SE0203552A 2002-12-02 2002-12-02 Thrombin concentration SE0203552D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE0203552A SE0203552D0 (en) 2002-12-02 2002-12-02 Thrombin concentration
PCT/SE2003/001548 WO2004050700A1 (en) 2002-12-02 2003-10-06 Process for preparating concentrated thrombin solutions and use in fibrin glue
AU2003267906A AU2003267906A1 (en) 2002-12-02 2003-10-06 Process for preparating concentrated thrombin solutions and use in fibrin glue

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0203552A SE0203552D0 (en) 2002-12-02 2002-12-02 Thrombin concentration

Publications (1)

Publication Number Publication Date
SE0203552D0 true SE0203552D0 (en) 2002-12-02

Family

ID=20289727

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0203552A SE0203552D0 (en) 2002-12-02 2002-12-02 Thrombin concentration

Country Status (3)

Country Link
AU (1) AU2003267906A1 (en)
SE (1) SE0203552D0 (en)
WO (1) WO2004050700A1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0796623B1 (en) * 1996-03-20 2005-05-25 Baxter Aktiengesellschaft Pharmaceutical preparation for the treatment of blood coagulation disorders
DE10012732A1 (en) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin composition, for use as hemostatic or as a component of fibrin glues, comprises non-covalently bonded inhibitor for stabilization

Also Published As

Publication number Publication date
AU2003267906A1 (en) 2004-06-23
WO2004050700A1 (en) 2004-06-17

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