SE0202719D0 - Process for mfg crystals of growth hormone - Google Patents

Process for mfg crystals of growth hormone

Info

Publication number
SE0202719D0
SE0202719D0 SE0202719A SE0202719A SE0202719D0 SE 0202719 D0 SE0202719 D0 SE 0202719D0 SE 0202719 A SE0202719 A SE 0202719A SE 0202719 A SE0202719 A SE 0202719A SE 0202719 D0 SE0202719 D0 SE 0202719D0
Authority
SE
Sweden
Prior art keywords
crystals
functional derivatives
growth hormone
mfg
propanol
Prior art date
Application number
SE0202719A
Other languages
Swedish (sv)
Inventor
Jonas Fransson
Mitra Mosharraf
Leena Lehtikari
Sinikka Uotila
Kalevi Visuri
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Priority to SE0202719A priority Critical patent/SE0202719D0/en
Publication of SE0202719D0 publication Critical patent/SE0202719D0/en
Priority to EP03795535A priority patent/EP1539797A1/en
Priority to BR0314187-0A priority patent/BR0314187A/en
Priority to MXPA05002826A priority patent/MXPA05002826A/en
Priority to JP2004535333A priority patent/JP2006513986A/en
Priority to AU2003259002A priority patent/AU2003259002A1/en
Priority to PCT/SE2003/001422 priority patent/WO2004024753A1/en
Priority to CA002498525A priority patent/CA2498525A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Abstract

A process is provided for manufacturing crystals of growth hormone (GH), or functional derivatives thereof, comprising the following steps : (a) preparing an aqueous solution of GH, or functional derivatives thereof, comprising 2-propanol, (b) incubating the solution prepared in step (a) to crystallize said GH, or functional derivatives thereof, and (c) isolating the crystals formed in step (b). A novel use of 2-propanol as a crystallizing agent for manufacturing crystals of GH, or functional derivatives thereof is also provided. In addition, crystals obtainable by the process and pharmaceutical compositions comprising the crystals are provided. The crystals are useful as a medicament, for the manufacture of such a medicament, and in a method of treating a mammal, including man.
SE0202719A 2002-09-13 2002-09-13 Process for mfg crystals of growth hormone SE0202719D0 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
SE0202719A SE0202719D0 (en) 2002-09-13 2002-09-13 Process for mfg crystals of growth hormone
EP03795535A EP1539797A1 (en) 2002-09-13 2003-09-12 Process for manufacturing crystals of growth hormone
BR0314187-0A BR0314187A (en) 2002-09-13 2003-09-12 Process for Producing Growth Hormone Crystals
MXPA05002826A MXPA05002826A (en) 2002-09-13 2003-09-12 Process for manufacturing crystals of growth hormone.
JP2004535333A JP2006513986A (en) 2002-09-13 2003-09-12 Method for producing growth hormone crystals
AU2003259002A AU2003259002A1 (en) 2002-09-13 2003-09-12 Process for manufacturing crystals of growth hormone
PCT/SE2003/001422 WO2004024753A1 (en) 2002-09-13 2003-09-12 Process for manufacturing crystals of growth hormone
CA002498525A CA2498525A1 (en) 2002-09-13 2003-09-12 Process for manufacturing crystals of growth hormone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0202719A SE0202719D0 (en) 2002-09-13 2002-09-13 Process for mfg crystals of growth hormone

Publications (1)

Publication Number Publication Date
SE0202719D0 true SE0202719D0 (en) 2002-09-13

Family

ID=20288983

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0202719A SE0202719D0 (en) 2002-09-13 2002-09-13 Process for mfg crystals of growth hormone

Country Status (8)

Country Link
EP (1) EP1539797A1 (en)
JP (1) JP2006513986A (en)
AU (1) AU2003259002A1 (en)
BR (1) BR0314187A (en)
CA (1) CA2498525A1 (en)
MX (1) MXPA05002826A (en)
SE (1) SE0202719D0 (en)
WO (1) WO2004024753A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2121186B1 (en) * 2007-03-05 2019-10-30 Rhodia Opérations Method for following up the crystallisation of a substance
GB201409451D0 (en) 2014-05-28 2014-07-09 Ipabc Ltd Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5130298A (en) * 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US5109117A (en) * 1990-06-26 1992-04-28 Monsanto Company Method of somatotropin naturation using urea and a soluble organic alcohol
DK168790D0 (en) * 1990-07-13 1990-07-13 Novo Nordisk As
US5849704A (en) * 1991-12-20 1998-12-15 Novo Nordisk A/S Pharmaceutical formulation
SE9302278D0 (en) * 1992-10-28 1993-07-02 Kabi Pharmacia Ab GROWTH HORMONE
JP3723857B2 (en) * 1998-02-04 2005-12-07 日本ケミカルリサーチ株式会社 Aqueous pharmaceutical composition containing human growth hormone

Also Published As

Publication number Publication date
JP2006513986A (en) 2006-04-27
AU2003259002A1 (en) 2004-04-30
BR0314187A (en) 2005-08-09
MXPA05002826A (en) 2005-09-30
WO2004024753A1 (en) 2004-03-25
CA2498525A1 (en) 2004-03-25
EP1539797A1 (en) 2005-06-15

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