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Priority claimed from US13/326,433external-prioritypatent/US8501930B2/en
Application filed by شركة اروهيد ماديسونfiledCriticalشركة اروهيد ماديسون
Publication of SA112340077B1publicationCriticalpatent/SA112340077B1/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Medicinal Preparation
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Abstract
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
SA112340077A2011-12-152012-12-12Peptide-based In vivo siRNA delivery system
SA112340077B1
(en)