SA112340077B1 - Peptide-based In vivo siRNA delivery system - Google Patents

Peptide-based In vivo siRNA delivery system

Info

Publication number
SA112340077B1
SA112340077B1 SA112340077A SA112340077A SA112340077B1 SA 112340077 B1 SA112340077 B1 SA 112340077B1 SA 112340077 A SA112340077 A SA 112340077A SA 112340077 A SA112340077 A SA 112340077A SA 112340077 B1 SA112340077 B1 SA 112340077B1
Authority
SA
Saudi Arabia
Prior art keywords
targeted
peptide
delivery system
polynucleotides
rnai
Prior art date
Application number
SA112340077A
Other languages
Arabic (ar)
Inventor
ويكيفيلد دارين
روزيما ديفيد
لويس ديفيد
Original Assignee
شركة اروهيد ماديسون
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/326,433 external-priority patent/US8501930B2/en
Application filed by شركة اروهيد ماديسون filed Critical شركة اروهيد ماديسون
Publication of SA112340077B1 publication Critical patent/SA112340077B1/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
SA112340077A 2011-12-15 2012-12-12 Peptide-based In vivo siRNA delivery system SA112340077B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13/326,433 US8501930B2 (en) 2010-12-17 2011-12-15 Peptide-based in vivo siRNA delivery system

Publications (1)

Publication Number Publication Date
SA112340077B1 true SA112340077B1 (en) 2015-11-10

Family

ID=49224588

Family Applications (1)

Application Number Title Priority Date Filing Date
SA112340077A SA112340077B1 (en) 2011-12-15 2012-12-12 Peptide-based In vivo siRNA delivery system

Country Status (3)

Country Link
AR (1) AR089244A1 (en)
SA (1) SA112340077B1 (en)
TW (1) TWI565476B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102459301B (en) * 2009-05-05 2016-01-20 米拉根医疗公司 lipophilic polynucleotide conjugates

Also Published As

Publication number Publication date
AR089244A1 (en) 2014-08-06
TW201325622A (en) 2013-07-01
TWI565476B (en) 2017-01-11

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