RU99125622A - METHOD FOR CLEANING CIS-DICHLOROAMMINISOPROPYLAMIN PLATINUM (II) - Google Patents

METHOD FOR CLEANING CIS-DICHLOROAMMINISOPROPYLAMIN PLATINUM (II)

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Publication number
RU99125622A
RU99125622A RU99125622/04A RU99125622A RU99125622A RU 99125622 A RU99125622 A RU 99125622A RU 99125622/04 A RU99125622/04 A RU 99125622/04A RU 99125622 A RU99125622 A RU 99125622A RU 99125622 A RU99125622 A RU 99125622A
Authority
RU
Russia
Prior art keywords
cis
platinum
dichloroamminisopropylamin
cleaning
filtrate
Prior art date
Application number
RU99125622/04A
Other languages
Russian (ru)
Other versions
RU2186068C2 (en
Inventor
Владимир Ильич Казбанов
Александр Константинович Старков
Галина Анатольевна Кожуховская
Original Assignee
Институт химии и химической технологии Сибирского Отделения РАН
Filing date
Publication date
Application filed by Институт химии и химической технологии Сибирского Отделения РАН filed Critical Институт химии и химической технологии Сибирского Отделения РАН
Priority to RU99125622A priority Critical patent/RU2186068C2/en
Priority claimed from RU99125622A external-priority patent/RU2186068C2/en
Publication of RU99125622A publication Critical patent/RU99125622A/en
Application granted granted Critical
Publication of RU2186068C2 publication Critical patent/RU2186068C2/en

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Claims (1)

Способ очистки цис-дихлороамминизопропиламинплатины (II), включающий растворение черновой соли в растворе NH4Cl 0,12-0,15 мол/г при 75-85oС, введение в фильтрат твердого оксалата аммония, выделение из фильтрата очищенного продукта после добавления концентрированной НСl, отличающийся тем, что выделяют очищенный продукт цис-дихлороамминизопропиламинплатины (II) с выходом 60%, черновую соль растворяют при соотношении ж:т = 20-25:1 вводя твердый оксалат аммония в количестве, обеспечивающем мольное отношение его к платине равным 4-5:1.The method of purification of cis-dichloroamminisopropylamineplatinum (II), comprising dissolving the crude salt in a solution of NH 4 Cl 0.12-0.15 mol / g at 75-85 o C, introducing solid ammonium oxalate into the filtrate, isolating the purified product from the filtrate after adding concentrated Hcl, characterized in that the purified product of cis-dichloroammine isopropylamine platinum (II) is isolated in 60% yield, the crude salt is dissolved in the ratio w: t = 20-25: 1 by introducing solid ammonium oxalate in an amount ensuring its molar ratio to platinum of 4- 5: 1.
RU99125622A 1999-12-02 1999-12-02 Method of purification of cis-dichloroamminiso-propylaminplatinum (ii) RU2186068C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU99125622A RU2186068C2 (en) 1999-12-02 1999-12-02 Method of purification of cis-dichloroamminiso-propylaminplatinum (ii)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU99125622A RU2186068C2 (en) 1999-12-02 1999-12-02 Method of purification of cis-dichloroamminiso-propylaminplatinum (ii)

Publications (2)

Publication Number Publication Date
RU99125622A true RU99125622A (en) 2001-10-20
RU2186068C2 RU2186068C2 (en) 2002-07-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU99125622A RU2186068C2 (en) 1999-12-02 1999-12-02 Method of purification of cis-dichloroamminiso-propylaminplatinum (ii)

Country Status (1)

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RU (1) RU2186068C2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102382144A (en) * 2011-08-22 2012-03-21 昆明贵研药业有限公司 Platinum (II) coordination complex with antitumor activity

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