RU99121138A - METHOD FOR PRODUCING 2- (Phenylamino) Phenylacetic Acid Derivatives - Google Patents

METHOD FOR PRODUCING 2- (Phenylamino) Phenylacetic Acid Derivatives

Info

Publication number
RU99121138A
RU99121138A RU99121138/04A RU99121138A RU99121138A RU 99121138 A RU99121138 A RU 99121138A RU 99121138/04 A RU99121138/04 A RU 99121138/04A RU 99121138 A RU99121138 A RU 99121138A RU 99121138 A RU99121138 A RU 99121138A
Authority
RU
Russia
Prior art keywords
phenylamino
phenylacetic acid
chloroacetylation
diphenylamine
producing
Prior art date
Application number
RU99121138/04A
Other languages
Russian (ru)
Other versions
RU2172309C2 (en
Inventor
Ольга Ахматовна Тамбиева
Олег Германович Угольников
Ирина Алексеевна Сальникова
Клара Романовна Петрова
Original Assignee
Государственный научный центр Российской Федерации "НИОПИК"
Filing date
Publication date
Application filed by Государственный научный центр Российской Федерации "НИОПИК" filed Critical Государственный научный центр Российской Федерации "НИОПИК"
Priority to RU99121138A priority Critical patent/RU2172309C2/en
Priority claimed from RU99121138A external-priority patent/RU2172309C2/en
Application granted granted Critical
Publication of RU2172309C2 publication Critical patent/RU2172309C2/en
Publication of RU99121138A publication Critical patent/RU99121138A/en

Links

Claims (3)

1. Способ получения производного 2-(фениламино)фенилуксусной кислоты, включающий хлорацетилирование хлорацетилхлоридом замещенного дифениламина, внутримолекулярную циклизацию полученного N-хлорацетилдифениламина, гидролиз 1-фенилиндолин-2-она, выделение соответствующей 2-(фениламино)-фенилуксусной кислоты, этерефикацию и реакцию с аминами, отличающийся тем, что при хлорацетилировании количество хлорацетилхлорида не превышает 5 молей на 1 моль дифениламина; после гидролиза в водно-спиртовой среде осуществляют промежуточное выделение соли производного 2-(фениламино)фенилуксусной кислоты, для чего используют смесь смешивающегося и несмешивающегося с водой растворителей.1. A method of producing a 2- (phenylamino) phenylacetic acid derivative, including chloroacetylation of substituted diphenylamine with chloroacetyl chloride, intramolecular cyclization of the obtained N-chloroacetyl diphenylamine, hydrolysis of 1-phenylindolin-2-one, isolation of the corresponding 2- (phenylamino) phenylacetone, phenylacetone amines, characterized in that when chloroacetylation the amount of chloroacetyl chloride does not exceed 5 moles per 1 mol of diphenylamine; after hydrolysis in a water-alcohol medium, an intermediate salt is isolated from the 2- (phenylamino) phenylacetic acid derivative, for which a mixture of solvents miscible and immiscible with water is used. 2. Способ по п.1, отличающийся тем, что хлорацетилирование замещенного дифениламина осуществляют в среде хлорацетилхлорида. 2. The method according to claim 1, characterized in that the chloroacetylation of the substituted diphenylamine is carried out in an environment of chloroacetyl chloride. 3. Способ по п.1, отличающийся тем, что хлорацетилирование замещенного дифениламина осуществляют в среде органического растворителя, объем которого не превышает 4 объемов хлорацетилхлорида. 3. The method according to claim 1, characterized in that the chloroacetylation of substituted diphenylamine is carried out in an organic solvent, the volume of which does not exceed 4 volumes of chloroacetyl chloride.
RU99121138A 1999-10-06 1999-10-06 Method of preparing 2-(phenylamino)phenylacetic acid derivatives RU2172309C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU99121138A RU2172309C2 (en) 1999-10-06 1999-10-06 Method of preparing 2-(phenylamino)phenylacetic acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU99121138A RU2172309C2 (en) 1999-10-06 1999-10-06 Method of preparing 2-(phenylamino)phenylacetic acid derivatives

Publications (2)

Publication Number Publication Date
RU2172309C2 RU2172309C2 (en) 2001-08-20
RU99121138A true RU99121138A (en) 2001-09-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU99121138A RU2172309C2 (en) 1999-10-06 1999-10-06 Method of preparing 2-(phenylamino)phenylacetic acid derivatives

Country Status (1)

Country Link
RU (1) RU2172309C2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103145574B (en) * 2013-04-02 2018-08-21 中国人民解放军防化学院 A kind of preparation method of diclofenac sodium

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