RU99120174A - HYDROMETHYL DERIVATIVES 2-AMINO-1,2,3,4-TETRAGIDRONAPTALINE AS A CARDIOVASCULAR AGENT - Google Patents

HYDROMETHYL DERIVATIVES 2-AMINO-1,2,3,4-TETRAGIDRONAPTALINE AS A CARDIOVASCULAR AGENT

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Publication number
RU99120174A
RU99120174A RU99120174/04A RU99120174A RU99120174A RU 99120174 A RU99120174 A RU 99120174A RU 99120174/04 A RU99120174/04 A RU 99120174/04A RU 99120174 A RU99120174 A RU 99120174A RU 99120174 A RU99120174 A RU 99120174A
Authority
RU
Russia
Prior art keywords
compound according
asterisk
single bond
alkyl group
carbon atom
Prior art date
Application number
RU99120174/04A
Other languages
Russian (ru)
Inventor
Стефания МОНТАНАРИ
Паоло КАВАЛЛЕРИ
Франческо Сантанджело
Кристина ФРАИРЕ
Джанкарло ГРАНЧИНИ
Мауро Наполетано
Франческо МАРЧИНИ
Лоренцо ПРАДЕЛЛА
Клаудио Семераро
Original Assignee
Дзамбон Гроуп С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзамбон Гроуп С.П.А. filed Critical Дзамбон Гроуп С.П.А.
Publication of RU99120174A publication Critical patent/RU99120174A/en

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Claims (6)

1. Соединение формулы
Figure 00000001

где r является целым числом, выбранным из 5, 6 и 7
s является целым числом, выбранным из 2 и 3;
А представляет О или одинарную связь;
R'4, R'5 и R'6, одновременно или порознь, представляют водород, ОН, галоид, нитро, C1-C4 алкил, C1-C4 алкокси, C1-C4 алкилтио, NH2, моно- или ди-C1-C4 алкиламино, SH, C1-C4 алкилсульфонил, C1-C4 алкоксикарбонил, NHCHO, C1-C4 алкилкарбониламино, NHCONH2, C1-C4 алкилсульфониламино, C1-C4 алкиламиносульфонил, SO2NH2, NHSO2NH2, СООН, SO3H, CONH2, СН2ОН или фенил; или
R'4 и R'5, в орто положении друг к другу, образуют вместе цепь из 3 или 4 групп, выбранных из CT'T", СО, S, О и NT"', где T' представляет атом водорода или C1-C4 алкильную группу, Т" представляет атом водорода, C1-C4 алкильную группу или аминогруппу и Т"' представляет атом водорода или C1-C4 алкильную группу; или Т' вместе с соседними Т" или Т"' образует одинарную связь, или Т" вместе с соседними Т' или Т"' образует одинарную связь;
звездочкой отмечается асимметрический атом углерода;
и его фармацевтически приемлемые соли.1. The compound of the formula
Figure 00000001

where r is an integer selected from 5, 6 and 7
s is an integer selected from 2 and 3;
A represents O or a single bond;
R ′ 4 , R ′ 5 and R ′ 6 , either simultaneously or separately, represent hydrogen, OH, halo, nitro, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, NH 2 , mono - or di C 1 -C 4 alkylamino, SH, C 1 -C 4 alkylsulfonyl, C 1 -C 4 alkoxycarbonyl, NHCHO, C 1 -C 4 alkylcarbonylamino, NHCONH 2 , C 1 -C 4 alkylsulfonylamino, C 1 -C 4 alkylaminosulfonyl, SO 2 NH 2 , NHSO 2 NH 2 , COOH, SO 3 H, CONH 2 , CH 2 OH, or phenyl; or
R ' 4 and R' 5 , in the ortho position to each other, together form a chain of 3 or 4 groups selected from CT'T ", CO, S, O and NT"', where T' represents a hydrogen atom or C 1 A C 4 alkyl group, T "represents a hydrogen atom, a C 1 -C 4 alkyl group or an amino group, and T" represents a hydrogen atom or a C 1 -C 4 alkyl group; either T 'together with the neighboring T' or T '' forms a single bond, or T 'together with the neighboring T' or T '' forms a single bond;
an asymmetric carbon atom is marked with an asterisk;
and its pharmaceutically acceptable salts. 2. Соединение по п. 1, где атом углерода, отмеченный звездочкой, имеет S конфигурацию. 2. The compound according to claim 1, where the carbon atom marked with an asterisk has the S configuration. 3. Соединение по п. 1, где r равняется 6 и атом углерода, отмеченный звездочкой, имеет S конфигурацию. 3. The compound according to claim 1, where r is 6 and the carbon atom marked with an asterisk has the S configuration. 4. Способ приготовления соединения по п. 1, включающий снятие защиты и последующее восстановление соединения формулы
Figure 00000002

где PG, r, s, A, R'4, R'5 и R'6 являются такими: как они определены по п. 1.4. The method of preparation of the compound according to claim 1, comprising removing the protection and the subsequent restoration of the compounds of formula
Figure 00000002

where PG, r, s, A, R ' 4 , R' 5 and R ' 6 are as follows: as defined in claim 1. 5. Фармацевтическая композиция, содержащая терапевтически эффективное количество соединения по п. 1 в смеси с приемлемым носителем. 5. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 in a mixture with an acceptable carrier. 6. Фармацевтическая композиция по п. 5 для лечения сердечнососудистых заболеваний. 6. The pharmaceutical composition according to claim 5 for the treatment of cardiovascular diseases.
RU99120174/04A 1997-02-26 1998-02-04 HYDROMETHYL DERIVATIVES 2-AMINO-1,2,3,4-TETRAGIDRONAPTALINE AS A CARDIOVASCULAR AGENT RU99120174A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI97A0000415 1997-02-26

Publications (1)

Publication Number Publication Date
RU99120174A true RU99120174A (en) 2001-06-27

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