RU99114119A - Non-narcotic analgesic and antipyretic drugs of the parkocet type and method for its preparation - Google Patents
Non-narcotic analgesic and antipyretic drugs of the parkocet type and method for its preparationInfo
- Publication number
- RU99114119A RU99114119A RU99114119/14A RU99114119A RU99114119A RU 99114119 A RU99114119 A RU 99114119A RU 99114119/14 A RU99114119/14 A RU 99114119/14A RU 99114119 A RU99114119 A RU 99114119A RU 99114119 A RU99114119 A RU 99114119A
- Authority
- RU
- Russia
- Prior art keywords
- starch
- base
- caffeine
- preparation
- codeine
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims 4
- 239000000730 antalgic agent Substances 0.000 title claims 2
- 239000002221 antipyretic Substances 0.000 title claims 2
- 229920002472 Starch Polymers 0.000 claims 7
- 235000019698 starch Nutrition 0.000 claims 7
- 239000008107 starch Substances 0.000 claims 7
- OROGSEYTTFOCAN-DNJOTXNNSA-N Codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 6
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 6
- 239000003826 tablet Substances 0.000 claims 5
- 229960001948 caffeine Drugs 0.000 claims 3
- 229960004126 codeine Drugs 0.000 claims 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- 239000008896 Opium Substances 0.000 claims 2
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 2
- 150000003797 alkaloid derivatives Chemical class 0.000 claims 2
- 229930013930 alkaloids Natural products 0.000 claims 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 229960001027 opium Drugs 0.000 claims 2
- RZVAJINKPMORJF-UHFFFAOYSA-N p-acetaminophenol Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 2
- 229960005489 paracetamol Drugs 0.000 claims 2
- 229930002161 purine alkaloids Natural products 0.000 claims 2
- 150000003212 purines Chemical class 0.000 claims 2
- JWBPVFVNISJVEM-UHFFFAOYSA-M sodium;1,3,7-trimethylpurine-2,6-dione;benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1.CN1C(=O)N(C)C(=O)C2=C1N=CN2C JWBPVFVNISJVEM-UHFFFAOYSA-M 0.000 claims 2
- 239000000454 talc Substances 0.000 claims 2
- 229910052623 talc Inorganic materials 0.000 claims 2
- DKSZLDSPXIWGFO-BLOJGBSASA-N (4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 claims 1
- 229960004415 Codeine Phosphate Drugs 0.000 claims 1
- 229940096978 Oral Tablet Drugs 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000000202 analgesic Effects 0.000 claims 1
- 230000001754 anti-pyretic Effects 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000010410 dusting Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000007935 oral tablet Substances 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 235000012222 talc Nutrition 0.000 claims 1
- 238000005550 wet granulation Methods 0.000 claims 1
Claims (1)
Ацетисалициловая кислота - 31,75-35,09
Парацетамол - 31,75-35,09
Кофеин основание (кофеин бензоат натрий в пересчете на кофеин основание) - 7,94-8,77
Кодеин основание (кодеин фосфат в пересчете на кодеин основание) - 1,27-1,40
Вспомогательные вещества
Микрокристаллическая целлюлоза - 9,52-10,53
Крахмал - 11,59-12,81
Тальк - 0,48-0,53
2. Способ получения лекарственного средства, обладающего анальгетическим и жаропонижающим действием, включающий приготовление таблетной массы путем перемешивания компонентов, влажной грануляции и сушки, последующее таблетирование, отличающийся тем, что в процессе приготовления таблетной массы ацетилсалициловую кислоту вводят в уже готовые и высушенные гранулы.1. Non-narcotic analgesic and antipyretic drug in the form of tablets for oral administration, comprising as main components acetylsalicylic acid, paracetamol, purine alkaloid, opium alkaloid, as well as additional talc, starch and microcrystalline cellulose and a method for preparing it in the form of an oral tablet characterized in that, as a purine alkaloid, it contains caffeine base or sodium caffeine benzoate, as opium alkaloid contains codeine base or odein phosphate in the following ratio, wt.%:
Acetisalicylic acid - 31.75-35.09
Paracetamol - 31.75-35.09
Caffeine base (caffeine sodium benzoate in terms of caffeine base) - 7.94-8.77
Codeine base (codeine phosphate in terms of codeine base) - 1.27-1.40
Excipients
Microcrystalline cellulose - 9.52-10.53
Starch - 11.59-12.81
Talc - 0.48-0.53
2. A method of obtaining a medicinal product having analgesic and antipyretic effects, including the preparation of a tablet mass by mixing the components, wet granulation and drying, subsequent tabletting, characterized in that during the preparation of the tablet mass acetylsalicylic acid is introduced into ready-made and dried granules.
Крахмал в порошке для получения таблетной массы - 9,06-10,49
Крахмал, для приготовления крахмального клейстера - 0,19-0,26
Крахмал для опудривания гранул - 2,34-2,063. The method according to p. 2, characterized in that in the process of preparing the mass for tabletting starch in powder is consumed in the following amounts from the tablet mass, wt.%:
Powdered starch to obtain tablet mass - 9.06-10.49
Starch, for the preparation of starch paste - 0.19-0.26
Granule dusting starch - 2.34-2.06
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU99114119/14A RU2173999C2 (en) | 1999-06-23 | 1999-06-23 | Nonnarcotic analgetic and antipyretic drug and method of its preparing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU99114119/14A RU2173999C2 (en) | 1999-06-23 | 1999-06-23 | Nonnarcotic analgetic and antipyretic drug and method of its preparing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU99114119A true RU99114119A (en) | 2000-02-10 |
| RU2173999C2 RU2173999C2 (en) | 2001-09-27 |
Family
ID=35208889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99114119/14A RU2173999C2 (en) | 1999-06-23 | 1999-06-23 | Nonnarcotic analgetic and antipyretic drug and method of its preparing |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2173999C2 (en) |
-
1999
- 1999-06-23 RU RU99114119/14A patent/RU2173999C2/en not_active IP Right Cessation
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