RU98122366A - IMPROVED METHOD OF LACTONIZATION IN OBTAINING STATINS - Google Patents
IMPROVED METHOD OF LACTONIZATION IN OBTAINING STATINSInfo
- Publication number
- RU98122366A RU98122366A RU98122366/04A RU98122366A RU98122366A RU 98122366 A RU98122366 A RU 98122366A RU 98122366/04 A RU98122366/04 A RU 98122366/04A RU 98122366 A RU98122366 A RU 98122366A RU 98122366 A RU98122366 A RU 98122366A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- reaction mixture
- obtaining
- lactonization
- statins
- Prior art date
Links
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title 1
- 238000007273 lactonization reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000011541 reaction mixture Substances 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 239000012296 anti-solvent Substances 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- CPBZARXQRZTYGI-UHFFFAOYSA-N 3-cyclopentylpropylcyclohexane Chemical compound C1CCCCC1CCCC1CCCC1 CPBZARXQRZTYGI-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 239000008079 hexane Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- IMNFDUFMRHMDMM-UHFFFAOYSA-N n-heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 0 *C(CC(C1)=O)CC1=O Chemical compound *C(CC(C1)=O)CC1=O 0.000 description 1
Claims (11)
где R представляет
где R1 представляет Н или CH3,
включающий обработку соединения формулы II
где Z представляет водород, катион металла, или NH4 и R является таким, как определено выше, слабой органической кислотой в отсутствие сильной кислоты при температуре ниже 55°С с получением реакционной смеси и извлечение указанного соединения формулы I из указанной реакционной смеси.1. The method of obtaining the compounds of formula I
where R represents
where R 1 represents H or CH 3 ,
comprising treating a compound of formula II
where Z is hydrogen, a metal cation, or NH 4 and R is, as defined above, a weak organic acid in the absence of a strong acid at a temperature below 55 ° C. to obtain a reaction mixture and recovering said compound of formula I from said reaction mixture.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/064,285 US5917058A (en) | 1997-10-28 | 1998-04-22 | Process of lactonization in the preparation of statins |
US09/064,285 | 1998-04-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU98122366A true RU98122366A (en) | 2000-09-27 |
RU2214407C2 RU2214407C2 (en) | 2003-10-20 |
Family
ID=22054869
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU98122366/04A RU2214407C2 (en) | 1998-04-22 | 1998-12-09 | Improved method for lactonization in preparing statins |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0955297B9 (en) |
AT (1) | ATE264849T1 (en) |
DE (1) | DE69823333T2 (en) |
DK (1) | DK0955297T3 (en) |
ES (1) | ES2217485T3 (en) |
HK (1) | HK1023572A1 (en) |
HU (1) | HUP9802936A3 (en) |
PT (1) | PT955297E (en) |
RU (1) | RU2214407C2 (en) |
ZA (1) | ZA9810764B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2127500A (en) | 1999-11-11 | 2001-06-06 | Biocon India Limited | Process for manufacturing simvastatin and the novel intermediates |
US6573385B1 (en) | 1999-11-11 | 2003-06-03 | Biocon India Limited | Process for manufacturing simvastatin and novel intermediates thereof |
SI21235A (en) * | 2001-05-18 | 2003-12-31 | Aurobindo Pharma Limited | A process for lactonization to produce simvastatin |
KR100407758B1 (en) * | 2001-08-27 | 2003-12-01 | 씨제이 주식회사 | Process of lactonization in the preparation of statins |
US6603022B1 (en) | 2002-05-10 | 2003-08-05 | Biocon India Limited | Process for manufacturing Simvastatin and novel intermediates thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4820850A (en) * | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
US4916239A (en) * | 1988-07-19 | 1990-04-10 | Merck & Co., Inc. | Process for the lactonization of mevinic acids and analogs thereof |
US5159104A (en) * | 1991-05-01 | 1992-10-27 | Merck & Co., Inc. | Process to simvastatin ester |
US5393893A (en) * | 1993-11-08 | 1995-02-28 | Apotex, Inc. | Process for producing simvastatin and analogs thereof |
-
1998
- 1998-11-25 ZA ZA9810764A patent/ZA9810764B/en unknown
- 1998-12-07 AT AT98123252T patent/ATE264849T1/en not_active IP Right Cessation
- 1998-12-07 ES ES98123252T patent/ES2217485T3/en not_active Expired - Lifetime
- 1998-12-07 DE DE69823333T patent/DE69823333T2/en not_active Expired - Fee Related
- 1998-12-07 DK DK98123252T patent/DK0955297T3/en active
- 1998-12-07 EP EP98123252A patent/EP0955297B9/en not_active Expired - Lifetime
- 1998-12-07 PT PT98123252T patent/PT955297E/en unknown
- 1998-12-09 RU RU98122366/04A patent/RU2214407C2/en not_active IP Right Cessation
- 1998-12-16 HU HU9802936A patent/HUP9802936A3/en unknown
-
2000
- 2000-05-08 HK HK00102749A patent/HK1023572A1/en not_active IP Right Cessation
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