RU98119892A - APPLICATION OF PETROLETTALINE DERIVATIVES FOR OBTAINING MEDICINES FOR THE TREATMENT OF NERVOUS SYSTEM DISEASES - Google Patents
APPLICATION OF PETROLETTALINE DERIVATIVES FOR OBTAINING MEDICINES FOR THE TREATMENT OF NERVOUS SYSTEM DISEASESInfo
- Publication number
- RU98119892A RU98119892A RU98119892/14A RU98119892A RU98119892A RU 98119892 A RU98119892 A RU 98119892A RU 98119892/14 A RU98119892/14 A RU 98119892/14A RU 98119892 A RU98119892 A RU 98119892A RU 98119892 A RU98119892 A RU 98119892A
- Authority
- RU
- Russia
- Prior art keywords
- radical
- nervous system
- hydrogen atom
- carbon atoms
- alkyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims 5
- 208000009025 Nervous System Disease Diseases 0.000 title claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 8
- 125000004432 carbon atoms Chemical group C* 0.000 claims 7
- 206010053643 Neurodegenerative disease Diseases 0.000 claims 4
- 201000009385 autoimmune disease of the nervous system Diseases 0.000 claims 4
- 229940079593 drugs Drugs 0.000 claims 4
- 230000002981 neuropathic Effects 0.000 claims 4
- 230000002093 peripheral Effects 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 208000000350 Central Nervous System Disease Diseases 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 201000008779 central nervous system disease Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- LDGIHZJOIQSHPB-UHFFFAOYSA-N 6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid Chemical compound C1C(C2)CC(C3)CC2CC13C1=CC(C2=CC3=CC=C(C=C3C=C2)C(=O)O)=CC=C1O LDGIHZJOIQSHPB-UHFFFAOYSA-N 0.000 claims 1
- 210000003169 Central Nervous System Anatomy 0.000 claims 1
- 229910003849 O-Si Inorganic materials 0.000 claims 1
- 229910003872 O—Si Inorganic materials 0.000 claims 1
- LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- -1 possibly mixed Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (4)
и их солей, где R1 является группой -COR6 или СН2ОН, в которой R6 является радикалом:
или радикалом OR7, где R7 является атомом водорода, алкилом, содержащим от 1 до 20 атомов углерода, моногидроксиалкилом или полигидроксиалкилом; r' и r'' являются атомом водорода, низшим алкилом, моно- или полигидроксиалкилом, арилом, возможно замещенным, или аминокислотным остатком или остатком аминосодержащего сахара, или вместе образуют гетероцикл, R2 является атомом водорода, разветвленным или неразветвленным алкилом, содержащим 1-15 атомов углерода, радикалом алкокси, содержащим 1-4 атомов углерода, или циклоалифатическим радикалом, R3 является атомом водорода, гидроксилом, разветвленным или неразветвленным алкилом, содержащим 1-4 атомов углерода, радикалом алкокси, содержащим 1-10 атомов углерода, замещенным или незамещенным циклоалифатическим радикалом, тиоциклоалифатическим радикалом или радикалом формулы -O-Si(СН3)2-R3, в которой R3 является низшим алкилом, линейным или разветвленным, R4 и R5, одинаковые или различные, являются атомом водорода, низшим алкилом, гидроксилом или низшим радикалом ацилокси, в качестве активного начала, для получения лекарственных средств, которые можно использовать для лечения периферических нейропатических состояний, нейродегенеративных заболеваний центральной нервной системы и аутоиммунных заболеваний нервной системы.1. The use of compounds of General formula I:
and their salts, where R 1 is a group —COR 6 or CH 2 OH, in which R 6 is the radical:
or the radical OR 7 , where R 7 is a hydrogen atom, alkyl containing from 1 to 20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl; r 'and r "are a hydrogen atom, lower alkyl, mono- or polyhydroxyalkyl, aryl optionally substituted, or an amino acid residue or an amino-containing sugar residue, or together form a heterocycle, R 2 is a hydrogen atom, a branched or unbranched alkyl containing 1- 15 carbon atoms, an alkoxy radical containing 1-4 carbon atoms or a cycloaliphatic radical, R 3 represents a hydrogen atom, hydroxyl, branched or unbranched alkyl having 1-4 carbon atoms, an alkoxy radical containing 1-10 volumes of carbon, substituted or unsubstituted cycloaliphatic radical, tiotsikloalifaticheskim radical or a radical -O-Si (CH 3) -R 2 of Formula 3 in which R 3 is lower alkyl, linear or branched, R 4 and R 5, identical or different, are hydrogen atom, lower alkyl, hydroxyl or lower acyloxy radical, as an active principle, to produce drugs that can be used to treat peripheral neuropathic conditions, neurodegenerative diseases of the central nervous system and autoimmune diseases of the nervous system.
в которой R6 являются радикалом:
или радикалом OR7, где R7 является атомом водорода, алкилом, содержащим 1-20 атомов углерода, моногидроксиалкилом или полигидроксиалкилом; а r' и r'' являются атомом водорода, низшим алкилом, моно- или полигидроксиалкилом, арилом, возможно замешенным, или аминокислотным остатком, или остатком аминосодержащего сахара, или вместе образуют гетероцикл, R является атомом водорода, гидроксилом, разветвленным или неразветвленным алкилом, содержащим 1-4 атомов углерода или радикалом алкокси, содержащим 1-4 атомов углерода, в качестве ативного начала для получения лекарственных средств, позволяющих лечить периферические нейропатологические состояния, нейродегенеративные заболевания центральной нервной системы и аутоиммунные заболевания нервной системы.2. The use of compounds of the general formula
in which R 6 are radical:
or the radical OR 7 , where R 7 is a hydrogen atom, alkyl containing 1-20 carbon atoms, monohydroxyalkyl or polyhydroxyalkyl; and r 'and r "are a hydrogen atom, lower alkyl, mono- or polyhydroxyalkyl, aryl, possibly mixed, or amino acid residue, or amino-containing sugar residue, or together form a heterocycle, R is a hydrogen atom, hydroxyl, branched or unbranched alkyl, containing 1-4 carbon atoms or alkoxy radicals, containing 1-4 carbon atoms, as an active principle for the production of drugs that allow treatment of peripheral neuropathological conditions, neurodegenerative diseases ntralnoy nervous system, and autoimmune diseases of the nervous system.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9604359A FR2747041B1 (en) | 1996-04-05 | 1996-04-05 | USE OF BENZONAPHTHALENIC DERIVATIVES FOR THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF NEUROPATHIES |
FR9604359 | 1996-04-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU98119892A true RU98119892A (en) | 2000-08-20 |
RU2160098C2 RU2160098C2 (en) | 2000-12-10 |
Family
ID=9490993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU98119892/14A RU2160098C2 (en) | 1996-04-05 | 1997-04-02 | Utilization of benzonaphthalene derivatives for preparing drugs destined for treatment of nervous system |
Country Status (23)
Country | Link |
---|---|
US (1) | US6043280A (en) |
EP (1) | EP0900078B1 (en) |
JP (1) | JP2000512619A (en) |
KR (1) | KR20000005179A (en) |
CN (1) | CN1221341A (en) |
AT (1) | ATE189385T1 (en) |
AU (1) | AU717704B2 (en) |
BR (1) | BR9708511A (en) |
CA (1) | CA2250755A1 (en) |
CZ (1) | CZ317698A3 (en) |
DE (1) | DE69701258T2 (en) |
ES (1) | ES2144857T3 (en) |
FR (1) | FR2747041B1 (en) |
GR (1) | GR3033061T3 (en) |
HU (1) | HUP9902167A3 (en) |
NO (1) | NO984651L (en) |
NZ (1) | NZ332158A (en) |
PL (1) | PL329219A1 (en) |
PT (1) | PT900078E (en) |
RU (1) | RU2160098C2 (en) |
SK (1) | SK133398A3 (en) |
WO (1) | WO1997037648A1 (en) |
ZA (1) | ZA972875B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2178B1 (en) | 1999-10-19 | 2003-04-23 | اف . هوفمان لاروش ايه جي | Treatment of emphysema using rar selective retinoid antagonists |
AU1760201A (en) * | 1999-11-12 | 2001-06-06 | Fred Hutchinson Cancer Research Center | Methods for treatment of human huntington's disease and methods of screening foractive agents |
TWI306450B (en) * | 2001-12-13 | 2009-02-21 | Wyeth Corp | Substituted phenyl naphthalenes as estrogenic agents |
UA77526C2 (en) * | 2002-06-07 | 2006-12-15 | Sanofi Aventis | Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy |
HUE059024T2 (en) | 2010-09-01 | 2022-10-28 | Univ Jefferson | Composition and method for muscle repair and regeneration |
KR101981930B1 (en) | 2017-08-10 | 2019-05-27 | 주식회사 에니텍시스 | Landing device |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5455248A (en) * | 1993-09-14 | 1995-10-03 | Sterling Winthrop Inc. | Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts, and compositions and method of use thereof |
-
1996
- 1996-04-05 FR FR9604359A patent/FR2747041B1/en not_active Expired - Fee Related
-
1997
- 1997-04-02 CA CA002250755A patent/CA2250755A1/en not_active Abandoned
- 1997-04-02 RU RU98119892/14A patent/RU2160098C2/en active
- 1997-04-02 CZ CZ983176A patent/CZ317698A3/en unknown
- 1997-04-02 HU HU9902167A patent/HUP9902167A3/en unknown
- 1997-04-02 US US09/155,598 patent/US6043280A/en not_active Expired - Fee Related
- 1997-04-02 BR BR9708511A patent/BR9708511A/en not_active Application Discontinuation
- 1997-04-02 ES ES97919465T patent/ES2144857T3/en not_active Expired - Lifetime
- 1997-04-02 KR KR1019980707851A patent/KR20000005179A/en not_active Application Discontinuation
- 1997-04-02 PT PT97919465T patent/PT900078E/en unknown
- 1997-04-02 PL PL97329219A patent/PL329219A1/en unknown
- 1997-04-02 NZ NZ332158A patent/NZ332158A/en unknown
- 1997-04-02 AT AT97919465T patent/ATE189385T1/en active
- 1997-04-02 SK SK1333-98A patent/SK133398A3/en unknown
- 1997-04-02 WO PCT/FR1997/000590 patent/WO1997037648A1/en not_active Application Discontinuation
- 1997-04-02 DE DE69701258T patent/DE69701258T2/en not_active Expired - Fee Related
- 1997-04-02 CN CN97195284A patent/CN1221341A/en active Pending
- 1997-04-02 AU AU23927/97A patent/AU717704B2/en not_active Ceased
- 1997-04-02 JP JP09535900A patent/JP2000512619A/en active Pending
- 1997-04-02 EP EP97919465A patent/EP0900078B1/en not_active Expired - Lifetime
- 1997-04-04 ZA ZA9702875A patent/ZA972875B/en unknown
-
1998
- 1998-10-05 NO NO984651A patent/NO984651L/en not_active Application Discontinuation
-
2000
- 2000-03-27 GR GR20000400749T patent/GR3033061T3/en unknown
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