RU98115572A - Конформационно ограниченные ароматические ингибиторы белка переноса микросомного триглицерида и способы их применения - Google Patents
Конформационно ограниченные ароматические ингибиторы белка переноса микросомного триглицерида и способы их примененияInfo
- Publication number
- RU98115572A RU98115572A RU98115572/04A RU98115572A RU98115572A RU 98115572 A RU98115572 A RU 98115572A RU 98115572/04 A RU98115572/04 A RU 98115572/04A RU 98115572 A RU98115572 A RU 98115572A RU 98115572 A RU98115572 A RU 98115572A
- Authority
- RU
- Russia
- Prior art keywords
- microsomic
- trigliceride
- conformation
- transfer
- methods
- Prior art date
Links
- 239000012268 protein inhibitor Substances 0.000 title 1
- 229940121649 protein inhibitors Drugs 0.000 title 1
- 0 CCCCOP(*)(CCCCC1(C(NC*(C)CO/C2=C/CC/C=C/C=C2)=O)c2ccccc2-c2c1cccc2)=O Chemical compound CCCCOP(*)(CCCCC1(C(NC*(C)CO/C2=C/CC/C=C/C=C2)=O)c2ccccc2-c2c1cccc2)=O 0.000 description 9
- BIBDYFWZCAAABT-UHFFFAOYSA-N CC(C)O[O](CNCCC1(C(NCC(F)(F)F)=O)c2ccccc2-c2ccccc12)(OC(C)C)=O Chemical compound CC(C)O[O](CNCCC1(C(NCC(F)(F)F)=O)c2ccccc2-c2ccccc12)(OC(C)C)=O BIBDYFWZCAAABT-UHFFFAOYSA-N 0.000 description 1
- OUMGSDVMCMGFAL-UHFFFAOYSA-N CC(CNC(CC1)CCC1C(NCCCCC1(C(NCC(F)(F)F)O)c2ccccc2-c2c1cccc2)=O)=O Chemical compound CC(CNC(CC1)CCC1C(NCCCCC1(C(NCC(F)(F)F)O)c2ccccc2-c2c1cccc2)=O)=O OUMGSDVMCMGFAL-UHFFFAOYSA-N 0.000 description 1
- NPIQENBBUVFFSZ-NQUIPPIDSA-N NC(CC[C@H](C(NCCCCC1(C(NCC(F)(F)F)O)c2ccccc2-c2ccccc12)=O)NC(c1ccccc1-c1ccc(C(F)(F)F)cc1)=O)=O Chemical compound NC(CC[C@H](C(NCCCCC1(C(NCC(F)(F)F)O)c2ccccc2-c2ccccc12)=O)NC(c1ccccc1-c1ccc(C(F)(F)F)cc1)=O)=O NPIQENBBUVFFSZ-NQUIPPIDSA-N 0.000 description 1
- YGOYTSQCTWCPHD-UHFFFAOYSA-N O=C(C(C1)C1c(cc1)cc2c1[n](CCCCC1(C(NCC(F)(F)F)=O)c3ccccc3-c3ccccc13)cc2)c(cccc1)c1-c1ccc(C(F)(F)F)cc1 Chemical compound O=C(C(C1)C1c(cc1)cc2c1[n](CCCCC1(C(NCC(F)(F)F)=O)c3ccccc3-c3ccccc13)cc2)c(cccc1)c1-c1ccc(C(F)(F)F)cc1 YGOYTSQCTWCPHD-UHFFFAOYSA-N 0.000 description 1
- OCMWTWWEEURLJC-UHFFFAOYSA-N O=C(C1(CCCCCCc2ccc(NC(c3ccccc3-c3ccc(C(F)(F)F)cc3)=O)nc2)c(cccc2)c2-c2ccccc12)NCC(F)(F)F Chemical compound O=C(C1(CCCCCCc2ccc(NC(c3ccccc3-c3ccc(C(F)(F)F)cc3)=O)nc2)c(cccc2)c2-c2ccccc12)NCC(F)(F)F OCMWTWWEEURLJC-UHFFFAOYSA-N 0.000 description 1
- RHKZQCUSAJXZGR-UHFFFAOYSA-N O=C(C1(CCCC[n](cc2)c(cc3)c2cc3NC(c2ccccc2)=O)c2ccccc2-c2ccccc12)NCC(F)(F)F Chemical compound O=C(C1(CCCC[n](cc2)c(cc3)c2cc3NC(c2ccccc2)=O)c2ccccc2-c2ccccc12)NCC(F)(F)F RHKZQCUSAJXZGR-UHFFFAOYSA-N 0.000 description 1
- MCANYUUIQXGBRM-UHFFFAOYSA-N OC(CC(CC1)CCC1C(NCCCCCC1(C(NCC(F)(F)F)O)c2ccccc2-c2c1cccc2)O)c1ccccc1-c1ccc(C(F)(F)F)cc1 Chemical compound OC(CC(CC1)CCC1C(NCCCCCC1(C(NCC(F)(F)F)O)c2ccccc2-c2c1cccc2)O)c1ccccc1-c1ccc(C(F)(F)F)cc1 MCANYUUIQXGBRM-UHFFFAOYSA-N 0.000 description 1
Images
Claims (1)
- Текст формулы заявки в факсимильном виде (см. чертежи).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60/010,346 | 1996-01-16 | ||
US60/017,224 | 1996-05-09 | ||
US60/030,370 | 1996-11-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
RU98115572A true RU98115572A (ru) | 2000-07-27 |
Family
ID=
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9656960B2 (en) | 2005-04-19 | 2017-05-23 | Surface Logix, Inc. | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9656960B2 (en) | 2005-04-19 | 2017-05-23 | Surface Logix, Inc. | Inhibitors of microsomal triglyceride transfer protein and apo-B secretion |
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