RU98110565A - NEW COMPOUNDS AND THEIR COMPOSITIONS Possessing ANTI-INFLAMMATORY AND ANTI-THROMBOTIC ACTIVITY - Google Patents

NEW COMPOUNDS AND THEIR COMPOSITIONS Possessing ANTI-INFLAMMATORY AND ANTI-THROMBOTIC ACTIVITY

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Publication number
RU98110565A
RU98110565A RU98110565/04A RU98110565A RU98110565A RU 98110565 A RU98110565 A RU 98110565A RU 98110565/04 A RU98110565/04 A RU 98110565/04A RU 98110565 A RU98110565 A RU 98110565A RU 98110565 A RU98110565 A RU 98110565A
Authority
RU
Russia
Prior art keywords
linear
branched
ono
carbon atoms
permissible
Prior art date
Application number
RU98110565/04A
Other languages
Russian (ru)
Other versions
RU2165921C2 (en
Inventor
Солдато Пьеро Дел
Франческо Санниколо
Original Assignee
Никокс С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT95MI002263A external-priority patent/IT1276071B1/en
Application filed by Никокс С.А. filed Critical Никокс С.А.
Publication of RU98110565A publication Critical patent/RU98110565A/en
Application granted granted Critical
Publication of RU2165921C2 publication Critical patent/RU2165921C2/en

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Claims (5)

1. Соединения общей формулы
A - X1 - NO2,
или их соли, использованные как лекарственные средства, где A = R(COX)t, t = 0 или 1; Х = 0, NH, NR1C, где R1C означает линейный или разветвленный, когда возможно, алкил 1 - 10 углеродных атомов, предпочтительно 1 - 4 или
Figure 00000001

Figure 00000002

где m и n означают целые числа от 1 до 6; R2a означает Н, СН3, связывание с X1 может быть в любом положении кольца,
Хo = Х;
R выбран из
Figure 00000003

где R1 означает OCOR3 группу, где R3 означает метил, этил или линейным или разветвленный С3-C5 алкил, или остаток гетероцикла только с одним кольцом, имеющим 5 или 6 атомов, которое может быть ароматическим, частично или полностью гидрогенированным, содержащим один или больше гетероатомов, независимо выбранных из О, N и S;
R2 означает водород, гидрокси-группу, галоген, линейный или, когда допустимо, разветвленный алкил, имеющий 1 - 4 атомов углерода, линейный или, когда допустимо, разветвленный алкоксил, имеющий 1 - 4 атомов углерода, линейный или, когда допустимо, разветвленный перфторалкил, имеющий 1 - 4 атомов углерода, нитро, амино, моно- или диалкиламин с C1-C4 алкилом, R1 и R2 вместе являются диоксиметиленовой группой, с условием, что, когда X = NH, тогда Y означает этилен и R2 = H, R1 не может быть OCOR3 в положении 2, когда R3 означает метил, nI означает целое число 0 или 1, X1 в формуле A - X1 - NO2 означает бивалентный соединительный мостик, выбранный из следующих
-YO-
где Y выбран из линейный или, когда допустимо, разветвленный C1-C20 алкилен, циклоалкилен, имеющий 5 - 7 атомов углерода, необязательно замещенных,
Figure 00000004
,
где n означает целое число 1 - 6, R2a как указано выше, r = 0 или 1.1. Compounds of the general formula
A - X 1 - NO 2 ,
or their salts used as medicines, where A = R (COX) t , t = 0 or 1; X = 0, NH, NR 1C , where R 1C means linear or branched, when possible, alkyl of 1 to 10 carbon atoms, preferably 1 to 4 or
Figure 00000001

Figure 00000002

where m and n are integers from 1 to 6; R 2a means H, CH 3 , binding to X 1 may be in any position of the ring,
X o = X;
R is selected from
Figure 00000003

where R 1 means OCOR 3 group, where R 3 means methyl, ethyl or linear or branched C 3 -C 5 alkyl, or a heterocycle residue with only one ring having 5 or 6 atoms, which may be aromatic, partially or completely hydrogenated, containing one or more heteroatoms independently selected from O, N and S;
R 2 means hydrogen, hydroxy group, halogen, linear or, when permissible, branched alkyl having 1 to 4 carbon atoms, linear or, when permissible, branched alkoxyl having 1 to 4 carbon atoms, linear or, when permissible, branched perfluoroalkyl having 1 to 4 carbon atoms, nitro, amino, mono- or dialkylamine with C 1 -C 4 alkyl, R 1 and R 2 together are a dimethylene group, with the proviso that when X = NH then Y is ethylene and R 2 = H, R 1 cannot be OCOR 3 at position 2 when R 3 is methyl, nI is an integer of 0 or 1, X 1 is in f the formula A - X 1 - NO 2 means a bivalent connecting bridge selected from the following
-Y-
where Y is selected from linear or, when permissible, branched C 1 -C 20 alkylene, cycloalkylene having 5 to 7 carbon atoms, optionally substituted,
Figure 00000004
,
where n is an integer of 1 to 6, R 2a as described above, r = 0 or 1. 2. Соединения по п. 1, где R означает
Figure 00000005

где
Figure 00000006
означает -CH2 - ONO2, -CH2CH2CH2CH2ONO2, -CH2CH2ONO2, -CH2CH2OCH2CH2ONO2, -CH2CH2OCH2ONO2.2. The compound of claim 1, wherein R is
Figure 00000005

Where
Figure 00000006
means -CH 2 - ONO 2 , -CH 2 CH 2 CH 2 CH 2 ONO 2 , -CH 2 CH 2 ONO 2 , -CH 2 CH 2 OCH 2 CH 2 ONO 2 , -CH 2 CH 2 OCH 2 ONO 2 . 3. Применение соединений или их композиций по пп. 1 - 3 для получения лекарственных средств для септического шока. 3. The use of compounds or their compositions according to paragraphs. 1 - 3 to obtain drugs for septic shock. 4. Применение соединений или их композиций по пп. 1 - 3 для получения лекарственных средств в виде противовоспалительных и противотромботических продуктов. 4. The use of compounds or their compositions according to paragraphs. 1 - 3 for the production of medicines in the form of anti-inflammatory and antithrombotic products. 5. Фармацевтические композиции, содержащие соединение по любому из пп. 1-3 и фармацевтически приемлемый наполнитель. 5. Pharmaceutical compositions containing a compound according to any one of paragraphs. 1-3 and a pharmaceutically acceptable excipient.
RU98110565/04A 1995-10-31 1996-10-29 Nitrocompounds and pharmaceutical composition showing anti-inflammatory and antithrombotic activity RU2165921C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITM195A002263 1995-10-31
IT95MI002263A IT1276071B1 (en) 1995-10-31 1995-10-31 ANTI-INFLAMMATORY ACTIVITY COMPOSITES

Publications (2)

Publication Number Publication Date
RU98110565A true RU98110565A (en) 2000-04-27
RU2165921C2 RU2165921C2 (en) 2001-04-27

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US (1) US6040341A (en)
EP (1) EP0871606B1 (en)
JP (1) JP3880067B2 (en)
KR (1) KR100546038B1 (en)
AT (1) ATE193883T1 (en)
AU (1) AU709338B2 (en)
BR (1) BR9611175B1 (en)
CA (1) CA2235996C (en)
DE (1) DE69608916T2 (en)
DK (1) DK0871606T3 (en)
ES (1) ES2148808T3 (en)
GR (1) GR3033827T3 (en)
HU (1) HUP9802986A3 (en)
IT (1) IT1276071B1 (en)
PT (1) PT871606E (en)
RU (1) RU2165921C2 (en)
SI (1) SI0871606T1 (en)
WO (1) WO1997016405A1 (en)

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