RU98106478A - NEW CARBONIC ACID DERIVATIVES, THEIR PRODUCTION AND APPLICATION - Google Patents
NEW CARBONIC ACID DERIVATIVES, THEIR PRODUCTION AND APPLICATIONInfo
- Publication number
- RU98106478A RU98106478A RU98106478/04A RU98106478A RU98106478A RU 98106478 A RU98106478 A RU 98106478A RU 98106478/04 A RU98106478/04 A RU 98106478/04A RU 98106478 A RU98106478 A RU 98106478A RU 98106478 A RU98106478 A RU 98106478A
- Authority
- RU
- Russia
- Prior art keywords
- carbon atoms
- group
- alkyl
- naphthyl
- halogen
- Prior art date
Links
- 150000004649 carbonic acid derivatives Chemical class 0.000 title 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 25
- -1 phenoxyl Chemical group 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000001624 naphthyl group Chemical group 0.000 claims 4
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000004663 dialkyl amino group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 150000003254 radicals Chemical class 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- 125000004520 1,3,4-thiadiazolyl group Chemical group 0.000 claims 1
- FONOSWYYBCBQGN-UHFFFAOYSA-N Ethylene dione Chemical group O=C=C=O FONOSWYYBCBQGN-UHFFFAOYSA-N 0.000 claims 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N Propadiene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000004429 atoms Chemical group 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004619 benzopyranyl group Chemical group O1C(C=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 150000002825 nitriles Chemical class 0.000 claims 1
- PLXPTFQGYWXIEA-UHFFFAOYSA-N nitroformonitrile Chemical compound [O-][N+](=O)C#N PLXPTFQGYWXIEA-UHFFFAOYSA-N 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N oxygen atom Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atoms Chemical group 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Claims (1)
где R1 - тетразол, нитрил, карбоксил или гидролизируемый в группу СООН остаток;
R2 и R3 могут быть одинаковыми или различными и означают фенил или нафтил, которые могут быть замещены одним или несколькими остатками из группы, включающей галоген, цианогруппу, двуокись азота, гидроксил, алкил с 1 - 4 атомами углерода, галоидалкил с 1 - 4 атомами углерода, алкоксил с 1 - 4 атомами углерода, галоидалкоксил с 1 - 4 атомами углерода, феноксил, алкилтиогруппу с 1 - 4 атомами углерода, аминогруппу, бензилоксил, алкиламиногруппу с 1 - 4 атомами углерода или диалкиламиногруппу с 1 - 4 атомами углерода в каждой алкильной части; или фенил или нафтил, которые находятся в орто-положении друг от друга и связаны через непосредственную связь, метилен, этилен или этенилен, атом кислорода или серы;
R4 - фенил или нафтил, метилендиоксифенил, этилендиоксифенил, инданил, индолил, пиридил, бензопиранил, фуранил, бензофуранил, изооксазолил, изотиазолил, 1,3,4-тиадиазолил, пиримидинил, 2,3-дигидробензофуранил, бензотиенил, хинолинил, циклоалкил с 3 - 7 атомами углерода, тиенил, оксазолил, тиазолил, которые могут быть замещены одним или несколькими остатками из группы, включающей галоген, цианогруппу, гидроксил, двуокись азота, алкил с 1 - 4 атомами углерода, галоидалкил с 1 - 4 атомами углерода, алкоксил с 1 - 4 атомами углерода, галоидалкоксил с 1 - 4 атомами углерода, феноксил, алкилтиогруппу с 1 - 4 атомами углерода, аминогруппу, бензилоксигруппу, алкиламиногруппу с 1 - 4 атомами углерода или диалкиламиногруппу с 1 - 4 атомами углерода в каждой алкильной части, причем алкильные остатки вместе могут образовать кольцо;
R5 - алкил с 1 - 8 атомами углерода, алкенил с 3 - 6 атомами углерода, алкинил с 3 - 6 атомами углерода или циклоалкил с 3 - 8 атомами углерода, причем данные остатки могут быть одно- или многократно замещены галогеном, алкоксилом с 1 - 4 атомами углерода, алкилтиогруппой с 1 - 4 атомами углерода, алкиламиногруппой с 1 - 4 атомами углерода, диалкиламиногруппой с 1 - 4 атомами углерода; фенил, бензил, 1-метилнафтил, 2-метилнафтил или нафтил, которые могут быть замещены одним или несколькими остатками из группы, включающей галоген, цианогруппу, гидроксил, аминогруппу, алкил с 1 - 4 атомами углерода, алкоксил с 1 - 4 атомами углерода, феноксил, алкилтиогруппу с 1 - 4 атомами углерода, диоксометилен или диоксоэтилен;
n - 1,2.Carboxylic Acid Derivatives of Formula I
where R 1 is tetrazole, nitrile, carboxyl or a hydrolyzable moiety in the COOH group;
R 2 and R 3 may be the same or different and mean phenyl or naphthyl, which may be substituted by one or more radicals from the group consisting of halogen, cyano, nitrogen dioxide, hydroxyl, alkyl with 1 to 4 carbon atoms, haloalkyl with 1 to 4 carbon atoms, alkoxyl with 1 to 4 carbon atoms, haloalkoxyl with 1 to 4 carbon atoms, phenoxyl, an alkylthio group with 1 to 4 carbon atoms, an amino group, benzyloxyl, an alkylamino group with 1 to 4 carbon atoms or a dialkylamino group with 1 to 4 carbon atoms in each alkyl part; or phenyl or naphthyl, which are in the ortho position from each other and are connected via a direct bond, methylene, ethylene or ethenylene, an oxygen or sulfur atom;
R 4 - phenyl or naphthyl, methylenedioxyphenyl, ethylenedioxyphenyl, indanyl, indolyl, pyridyl, benzopyranyl, furanyl, benzofuranyl, isooxazolyl, isothiazolyl, 1,3,4-thiadiazolyl, pyrimidinyl, 2,3-dihydrobenzofuranyl, benzothienyl, xyl - 7 carbon atoms, thienyl, oxazolyl, thiazolyl, which may be substituted by one or more radicals from the group consisting of halogen, cyano, hydroxyl, nitrogen dioxide, alkyl with 1 to 4 carbon atoms, haloalkyl with 1 to 4 carbon atoms, alkoxyl with 1 to 4 carbon atoms, haloalkoxyl with 1 to 4 atom E carbon, phenoxy, alkylthio with 1 - 4 carbon atoms, an amino group, a benzyloxy group, an alkylamino group with 1 - 4 carbon atoms or dialkylamino having 1 - 4 carbon atoms in each alkyl moiety, wherein the alkyl radicals together may form a ring;
R 5 is alkyl with 1 to 8 carbon atoms, alkenyl with 3 to 6 carbon atoms, alkynyl with 3 to 6 carbon atoms or cycloalkyl with 3 to 8 carbon atoms, moreover, these residues can be substituted once or repeatedly by halogen, alkoxyl with 1 - 4 carbon atoms, an alkylthio group with 1 to 4 carbon atoms, an alkylamino group with 1 to 4 carbon atoms, a dialkylamino group with 1 to 4 carbon atoms; phenyl, benzyl, 1-methylnaphthyl, 2-methylnaphthyl or naphthyl, which may be substituted by one or more radicals from the group consisting of halogen, cyano, hydroxyl, amino, alkyl with 1 to 4 carbon atoms, alkoxy with 1 to 4 carbon atoms, phenoxy, alkylthio group with 1 to 4 carbon atoms, dioxomethylene or dioxoethylene;
n is 1.2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19533025.0 | 1995-09-07 | ||
DE19533025A DE19533025A1 (en) | 1995-09-07 | 1995-09-07 | New carboxylic acid derivatives, their production and use |
Publications (2)
Publication Number | Publication Date |
---|---|
RU98106478A true RU98106478A (en) | 2000-01-27 |
RU2175315C2 RU2175315C2 (en) | 2001-10-27 |
Family
ID=7771490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU98106478/04A RU2175315C2 (en) | 1995-09-07 | 1996-08-29 | Carboxylic acid derivatives |
Country Status (30)
Country | Link |
---|---|
US (1) | US6004988A (en) |
EP (1) | EP0862550B1 (en) |
JP (1) | JPH11512104A (en) |
KR (1) | KR19990044455A (en) |
CN (1) | CN1070841C (en) |
AR (1) | AR003532A1 (en) |
AT (1) | ATE197448T1 (en) |
AU (1) | AU705956B2 (en) |
BG (1) | BG63720B1 (en) |
BR (1) | BR9610139A (en) |
CA (1) | CA2228002A1 (en) |
CO (1) | CO5040228A1 (en) |
CZ (1) | CZ64198A3 (en) |
DE (2) | DE19533025A1 (en) |
ES (1) | ES2153124T3 (en) |
GR (1) | GR3034797T3 (en) |
HR (1) | HRP960400B1 (en) |
HU (1) | HUP9802329A3 (en) |
IL (1) | IL123213A (en) |
MY (1) | MY132151A (en) |
NO (1) | NO310651B1 (en) |
NZ (1) | NZ316940A (en) |
PL (1) | PL325398A1 (en) |
PT (1) | PT862550E (en) |
RU (1) | RU2175315C2 (en) |
SI (1) | SI0862550T1 (en) |
SK (1) | SK282082B6 (en) |
TR (1) | TR199800410T1 (en) |
WO (1) | WO1997009294A1 (en) |
ZA (1) | ZA967537B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7842727B2 (en) | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US6495719B2 (en) | 2001-03-27 | 2002-12-17 | Circagen Pharmaceutical | Histone deacetylase inhibitors |
US8026280B2 (en) | 2001-03-27 | 2011-09-27 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
CA2486303C (en) | 2002-05-22 | 2013-04-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors based on alpha-ketoepoxide compounds |
JP2006508986A (en) | 2002-11-20 | 2006-03-16 | エルラント ゲネ セラペウチクス エルエルシー | Treatment of lung cells with histone deacetylase inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4224572C2 (en) * | 1992-07-24 | 1996-04-18 | Sfs Ind Holding Ag | Fastening element for use in concrete or the like material |
US5686478A (en) * | 1993-07-20 | 1997-11-11 | Merck & Co. Inc. | Endothelin antagonists |
-
1995
- 1995-09-07 DE DE19533025A patent/DE19533025A1/en not_active Withdrawn
-
1996
- 1996-08-29 KR KR1019980701703A patent/KR19990044455A/en active IP Right Grant
- 1996-08-29 ES ES96930125T patent/ES2153124T3/en not_active Expired - Lifetime
- 1996-08-29 AU AU69295/96A patent/AU705956B2/en not_active Ceased
- 1996-08-29 HU HU9802329A patent/HUP9802329A3/en unknown
- 1996-08-29 RU RU98106478/04A patent/RU2175315C2/en not_active IP Right Cessation
- 1996-08-29 DE DE59606132T patent/DE59606132D1/en not_active Expired - Fee Related
- 1996-08-29 US US09/029,447 patent/US6004988A/en not_active Expired - Fee Related
- 1996-08-29 IL IL12321396A patent/IL123213A/en not_active IP Right Cessation
- 1996-08-29 TR TR1998/00410T patent/TR199800410T1/en unknown
- 1996-08-29 CZ CZ98641A patent/CZ64198A3/en unknown
- 1996-08-29 JP JP9510830A patent/JPH11512104A/en not_active Abandoned
- 1996-08-29 SK SK282-98A patent/SK282082B6/en unknown
- 1996-08-29 SI SI9630188T patent/SI0862550T1/en unknown
- 1996-08-29 WO PCT/EP1996/003793 patent/WO1997009294A1/en active IP Right Grant
- 1996-08-29 NZ NZ316940A patent/NZ316940A/en unknown
- 1996-08-29 PT PT96930125T patent/PT862550E/en unknown
- 1996-08-29 AT AT96930125T patent/ATE197448T1/en not_active IP Right Cessation
- 1996-08-29 CN CN96197840A patent/CN1070841C/en not_active Expired - Fee Related
- 1996-08-29 CA CA002228002A patent/CA2228002A1/en not_active Abandoned
- 1996-08-29 PL PL96325398A patent/PL325398A1/en unknown
- 1996-08-29 EP EP96930125A patent/EP0862550B1/en not_active Expired - Lifetime
- 1996-08-29 BR BR9610139A patent/BR9610139A/en not_active Application Discontinuation
- 1996-09-03 HR HR960400A patent/HRP960400B1/en not_active IP Right Cessation
- 1996-09-04 MY MYPI96003669A patent/MY132151A/en unknown
- 1996-09-05 CO CO96047377A patent/CO5040228A1/en unknown
- 1996-09-06 AR ARP960104272A patent/AR003532A1/en unknown
- 1996-09-06 ZA ZA9607537A patent/ZA967537B/en unknown
-
1998
- 1998-03-06 NO NO19981002A patent/NO310651B1/en not_active IP Right Cessation
- 1998-03-24 BG BG102347A patent/BG63720B1/en unknown
-
2000
- 2000-11-09 GR GR20000402475T patent/GR3034797T3/en not_active IP Right Cessation
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