RU98102403A - APPLICATION OF 1,4-DIHYDROPYRIDININE DERIVATIVES FOR PREVENTION AND TREATMENT OF ATHEROSCLEROTIC DEGRADATION OF ARTERIAL WALLS - Google Patents
APPLICATION OF 1,4-DIHYDROPYRIDININE DERIVATIVES FOR PREVENTION AND TREATMENT OF ATHEROSCLEROTIC DEGRADATION OF ARTERIAL WALLSInfo
- Publication number
- RU98102403A RU98102403A RU98102403/14A RU98102403A RU98102403A RU 98102403 A RU98102403 A RU 98102403A RU 98102403/14 A RU98102403/14 A RU 98102403/14A RU 98102403 A RU98102403 A RU 98102403A RU 98102403 A RU98102403 A RU 98102403A
- Authority
- RU
- Russia
- Prior art keywords
- manufacture
- medicament
- use according
- compound
- carbon atoms
- Prior art date
Links
- 230000003143 atherosclerotic effect Effects 0.000 title claims 3
- 230000015556 catabolic process Effects 0.000 title claims 3
- 238000006731 degradation reaction Methods 0.000 title claims 3
- 230000002265 prevention Effects 0.000 title 1
- 239000003814 drug Substances 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- -1 2-nitrophenyl Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 229940126601 medicinal product Drugs 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- ZDXUKAKRHYTAKV-MGBGTMOVSA-N 5-o-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-o-methyl (4r)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound C1([C@H]2C(=C(C)NC(C)=C2C(=O)OC)C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-MGBGTMOVSA-N 0.000 claims 1
- ZDXUKAKRHYTAKV-XIFFEERXSA-N 5-o-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-o-methyl (4s)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound C1([C@@H]2C(=C(C)NC(C)=C2C(=O)OC)C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-XIFFEERXSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- ZDXUKAKRHYTAKV-UHFFFAOYSA-N lercanidipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(C=2C=CC=CC=2)C=2C=CC=CC=2)C1C1=CC=CC([N+]([O-])=O)=C1 ZDXUKAKRHYTAKV-UHFFFAOYSA-N 0.000 claims 1
- 229960004294 lercanidipine Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Claims (10)
где Ph обозначает фенильную группу,
Аr обозначает 2-нитрофенильную, 3-нитрофенильную, 2,3-дихлорфенильную или бензофуразан-4-ильную группу,
А обозначает разветвленную алкиленовую группу, содержащую от 3 до 6 атомов углерода,
R обозначает линейноцепочечную или разветвленную алкильную группу, включающую от 1 до 6 атомов углерода, необязательно моно замещенную алкоксигруппой, содержащей от 1 до 6 атомов углерода,
R1 обозначает атом водорода, гидроксигруппу или алкильную группу, содержащую от 1 до 4 атомов углерода, и
R2 обозначает атом водорода или метильную группу,
или соль, энантиомер, гидрат или сольват такого соединения для получения лекарственного средства для профилактики, остановки или восстановления атеросклеротической деградации стенок артерий у пациентов.1. The use of compounds of General formula I
where Ph is a phenyl group,
Ar is a 2-nitrophenyl, 3-nitrophenyl, 2,3-dichlorophenyl or benzofurazan-4-yl group,
A denotes a branched alkylene group containing from 3 to 6 carbon atoms,
R is a linear or branched alkyl group containing from 1 to 6 carbon atoms, optionally mono-substituted with an alkoxy group containing from 1 to 6 carbon atoms,
R 1 represents a hydrogen atom, a hydroxy group or an alkyl group containing from 1 to 4 carbon atoms, and
R 2 represents a hydrogen atom or a methyl group,
or a salt, enantiomer, hydrate or solvate of such a compound for the manufacture of a medicament for the prophylaxis, arrest or restoration of atherosclerotic degradation of arterial walls in patients.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI95A001513 | 1995-07-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU98102403A true RU98102403A (en) | 2000-01-27 |
Family
ID=
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2425033C2 (en) * | 2005-09-16 | 2011-07-27 | Гленмарк Фармасьютикалз Лимитед | Polymorphous form of lercanidipine hydrochloride and synthesis method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2425033C2 (en) * | 2005-09-16 | 2011-07-27 | Гленмарк Фармасьютикалз Лимитед | Polymorphous form of lercanidipine hydrochloride and synthesis method thereof |
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