RU97112319A - METHOD FOR DETERMINING THE STAGE OF THE PATHOLOGICAL PROCESS IN TESTS OF EVALUATING THE FUNCTIONAL ACTIVITY OF LYMPHOCYTES - Google Patents

METHOD FOR DETERMINING THE STAGE OF THE PATHOLOGICAL PROCESS IN TESTS OF EVALUATING THE FUNCTIONAL ACTIVITY OF LYMPHOCYTES

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Publication number
RU97112319A
RU97112319A RU97112319/14A RU97112319A RU97112319A RU 97112319 A RU97112319 A RU 97112319A RU 97112319/14 A RU97112319/14 A RU 97112319/14A RU 97112319 A RU97112319 A RU 97112319A RU 97112319 A RU97112319 A RU 97112319A
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RU
Russia
Prior art keywords
activity
pathological process
value
lymphocytes
pathological
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RU97112319/14A
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Russian (ru)
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RU2175769C2 (en
Inventor
И.А. Тузанкина
В.Н. Шершнев
Original Assignee
И.А. Тузанкина
В.Н. Шершнев
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Publication date
Application filed by И.А. Тузанкина, В.Н. Шершнев filed Critical И.А. Тузанкина
Priority to RU97112319A priority Critical patent/RU2175769C2/en
Priority claimed from RU97112319A external-priority patent/RU2175769C2/en
Publication of RU97112319A publication Critical patent/RU97112319A/en
Application granted granted Critical
Publication of RU2175769C2 publication Critical patent/RU2175769C2/en

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Claims (1)

Способ определения активности патологического процесса в тестах оценки функциональной активности лимфоцитов в реакции Е-розеткообразования, отличающийся тем, что, с целью совершенствования способа диагностики активности патологических процессов, определения различных стадий развития заболеваний одним лабораторным методом, а также создания универсального экономичного и простого подхода к диагностике заболеваний различной нозологической принадлежности, в основе которых лежат воспалительные реакции, используется инкубация выделенной из крови лимфоцитарной взвеси в течение 90 мин с лекарственным препаратом иммуномодулирующего действия, содержащим естественные пептиды тимического или костно-мозгового происхождения, а затем после 2-минутного центрифугирования инкубация продолжается с эритроцитами барана в течение 18 ч, а затем рассчитывается индекс чувствительности по формуле:
Figure 00000001

и при значении ИЧ > 1,0 активность патологического процесса оценивается как низкая (чем выше значение ИЧ, тем меньше выражена активность процесса), а при ИЧ < 1,0 контактируется активность патологического процесса (чем меньше значение ИЧ, тем больше выражена активность процесса).A method for determining the activity of the pathological process in tests for assessing the functional activity of lymphocytes in the reaction of E-rosette formation, characterized in that, in order to improve the method for diagnosing the activity of pathological processes, determine the various stages of the development of diseases using one laboratory method, as well as create a universal economical and simple approach to diagnosis diseases of various nosological affiliations, which are based on inflammatory reactions, incubation is used hydrochloric blood lymphocyte suspension for 90 minutes with a medicament immunomodulating action, containing natural peptides thymic or medullary origin, and then after a 2 minute centrifugation incubation continues with sheep erythrocytes for 18 hours, and then calculated by the formula sensitivity index:
Figure 00000001

and if the ICh value is> 1.0, the activity of the pathological process is assessed as low (the higher the IC value, the less pronounced the activity of the process), and if the IC is <1.0, the activity of the pathological process is contacted (the lower the IC value, the more pronounced the process activity) .
RU97112319A 1997-07-08 1997-07-08 Method for determining pathological process stage in tests for evaluating functional activity of lymphocytes RU2175769C2 (en)

Priority Applications (1)

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RU97112319A RU2175769C2 (en) 1997-07-08 1997-07-08 Method for determining pathological process stage in tests for evaluating functional activity of lymphocytes

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Application Number Priority Date Filing Date Title
RU97112319A RU2175769C2 (en) 1997-07-08 1997-07-08 Method for determining pathological process stage in tests for evaluating functional activity of lymphocytes

Publications (2)

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RU97112319A true RU97112319A (en) 1999-06-10
RU2175769C2 RU2175769C2 (en) 2001-11-10

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