RU97109481A - N- (2,4,6-trimethylphenylcarbamoylmethyl) -n-allylmorpholinium bromide, manifesting anti-ischemic and antiarrhythmic action in ischemic heart disease and his / her pattern - Google Patents

N- (2,4,6-trimethylphenylcarbamoylmethyl) -n-allylmorpholinium bromide, manifesting anti-ischemic and antiarrhythmic action in ischemic heart disease and his / her pattern

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Publication number
RU97109481A
RU97109481A RU97109481/14A RU97109481A RU97109481A RU 97109481 A RU97109481 A RU 97109481A RU 97109481/14 A RU97109481/14 A RU 97109481/14A RU 97109481 A RU97109481 A RU 97109481A RU 97109481 A RU97109481 A RU 97109481A
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RU
Russia
Prior art keywords
trimethylphenylcarbamoylmethyl
ischemic
bromide
allylmorpholinium
heart disease
Prior art date
Application number
RU97109481/14A
Other languages
Russian (ru)
Other versions
RU2105554C1 (en
Inventor
Л.Н. Серпов
Я.В. Костин
И.Я. Костина
В.Э. Олейников
Л.А. Шароварникова
Original Assignee
Всероссийский научный центр по безопасности биологически активных веществ
Закрытое акционерное общество "Фармакор"
Filing date
Publication date
Application filed by Всероссийский научный центр по безопасности биологически активных веществ, Закрытое акционерное общество "Фармакор" filed Critical Всероссийский научный центр по безопасности биологически активных веществ
Priority to RU97109481A priority Critical patent/RU2105554C1/en
Priority claimed from RU97109481A external-priority patent/RU2105554C1/en
Application granted granted Critical
Publication of RU2105554C1 publication Critical patent/RU2105554C1/en
Publication of RU97109481A publication Critical patent/RU97109481A/en

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Claims (2)

1. N-(2,4,6-Триметилфенилкарбамоилметил)-N-аллилморфолиний бромид формулы I:
Figure 00000001

проявляющий противоишемическое и антиаритмическое действие болезни сердца.1. N- (2,4,6-Trimethylphenylcarbamoylmethyl) -N-allylmorpholine bromide of the formula I:
Figure 00000001

exhibiting anti-ischemic and anti-arrhythmic action of heart disease. 2. Способ получения N-(2,4,6-триметилфенилкарбамоилметил)-N-аллилморфолиний бромида формулы I, отличающийся тем, что N-(2,4,6-триметилфенилкарбамоилметил) морфолин подвергают взаимодействию с бромистым аллилом в среде изопропилового спирта при мольном соотношении N-(2,4,6-триметилфенилкарбамоилметил) морфолина и бромистого аллила 1 : 1,4-1,6, соответственно, и температуре 55 - 65oС с последующим охлаждением реакционной смеси до комнатной температуры и выделением N-(2,4,6-триметилфенилкарбамоилметил)-N-аллилморфолиний бромида.2. The method of obtaining N- (2,4,6-trimethylphenylcarbamoylmethyl) -N-allylmorpholine bromide of the formula I, characterized in that the N- (2,4,6-trimethylphenylcarbamoylmethyl) morpholine is subjected to interaction with allyl bromide in isopropyl alcohol at molar the ratio of N- (2,4,6-trimethylphenylcarbamoylmethyl) morpholine and allyl bromide 1: 1.4-1.6, respectively, and a temperature of 55-65 o C, followed by cooling the reaction mixture to room temperature and release of N- (2, 4,6-trimethylphenylcarbamoylmethyl) -N-allylmorpholinium bromide.
RU97109481A 1997-06-24 1997-06-24 N-(2,4,6-trimethylphenylcarbamoylmethyl)-n-allylmorpholinium bromide showing antiischemic and antiarrhythmic effects at ischemic heart disease and a method of its synthesis RU2105554C1 (en)

Priority Applications (1)

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RU97109481A RU2105554C1 (en) 1997-06-24 1997-06-24 N-(2,4,6-trimethylphenylcarbamoylmethyl)-n-allylmorpholinium bromide showing antiischemic and antiarrhythmic effects at ischemic heart disease and a method of its synthesis

Applications Claiming Priority (1)

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RU97109481A RU2105554C1 (en) 1997-06-24 1997-06-24 N-(2,4,6-trimethylphenylcarbamoylmethyl)-n-allylmorpholinium bromide showing antiischemic and antiarrhythmic effects at ischemic heart disease and a method of its synthesis

Publications (2)

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RU2105554C1 RU2105554C1 (en) 1998-02-27
RU97109481A true RU97109481A (en) 1998-09-10

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MX2021010869A (en) 2019-03-11 2022-01-19 Nocion Therapeutics Inc Ester substituted ion channel blockers and methods for use.
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP2022525856A (en) 2019-03-11 2022-05-20 ノシオン セラピューティクス，インコーポレイテッド Charged ion channel blockers and usage
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP2022527690A (en) 2019-03-11 2022-06-03 ノシオン セラピューティクス，インコーポレイテッド Charged ion channel blockers and usage
JP2023500891A (en) 2019-11-06 2023-01-11 ノシオン セラピューティクス，インコーポレイテッド Charged ion channel blockers and methods of use
US10933055B1 (en) 2019-11-06 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
AU2021236130A1 (en) 2020-03-11 2022-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use

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