RU97107992A - QUINOLINE DERIVATIVES - Google Patents
QUINOLINE DERIVATIVESInfo
- Publication number
- RU97107992A RU97107992A RU97107992/04A RU97107992A RU97107992A RU 97107992 A RU97107992 A RU 97107992A RU 97107992/04 A RU97107992/04 A RU 97107992/04A RU 97107992 A RU97107992 A RU 97107992A RU 97107992 A RU97107992 A RU 97107992A
- Authority
- RU
- Russia
- Prior art keywords
- carbon atoms
- group
- phenyl
- pyridyl
- integer
- Prior art date
Links
- 229940093918 Quinoline gynecological antiinfectives Drugs 0.000 title 1
- 229940027991 antiseptics and disinfectants Quinoline derivatives Drugs 0.000 title 1
- 150000003248 quinolines Chemical class 0.000 title 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 18
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- -1 nitro, amino, phenyl Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- SMWDFEZZVXVKRB-UHFFFAOYSA-N quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000000335 thiazolyl group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000004429 atoms Chemical group 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 2
- 125000004430 oxygen atoms Chemical group O* 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 239000010802 sludge Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 125000004434 sulfur atoms Chemical group 0.000 claims 2
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
Claims (3)
где R1 представляет водород, алкильную группу, имеющую от 1 до 6 углеродных атомов, аминогруппу, имеющую формулу -NR4R5, в которой каждый из R4 и R5 независимо представляет водород, алкил с 1-6 углеродными атомами, фенил, пиридил, пиримидил или бензоил, или фенильную группу, нафтильную группу, циклоалкильную группу, имеющую от 3 до 8 углеродных атомов, или 5-8-членную гетероциклическую группу, содержащую в качестве кольцевых атомов 1-2 атома азота, кислорода или серы и остальные - атомы углерода, каждая из которых может иметь в качестве заместителя алкил с 1-6 углеродными атомами, алкокси с 1-6 углеродными атомами, галоген, гидроксил, галогеналкил с 1-6 углеродными атомами, галогеналкокси с 1-6 углеродными атомами, нитро, амино, фенил, тиенил, фурил, тиазолил или пиридил;
Z представляет O, S, C=O или CH2;
Е представляет S или O;
m представляет целое число от 0 до 4;
p представляет целое число от 0 до 4;
q представляет целое число от 0 до 4; и
двойная линия, состоящая из пунктирной и сплошной линий, означает одинарную или двойную связь.1. Derived quinoline having the formula I
where R 1 represents hydrogen, an alkyl group having from 1 to 6 carbon atoms, an amino group having the formula —NR 4 R 5 , in which each of R 4 and R 5 independently represents hydrogen, alkyl with 1-6 carbon atoms, phenyl, a pyridyl, pyrimidyl or benzoyl, or a phenyl group, a naphthyl group, a cycloalkyl group having from 3 to 8 carbon atoms, or a 5-8-membered heterocyclic group containing 1-2 nitrogen, oxygen or sulfur atoms as ring atoms and the rest - carbon atoms, each of which may have a substituent alk sludge with 1-6 carbon atoms, alkoxy with 1-6 carbon atoms, halogen, hydroxyl, haloalkyl with 1-6 carbon atoms, halogenoalkoxy with 1-6 carbon atoms, nitro, amino, phenyl, thienyl, furyl, thiazolyl or pyridyl;
Z is O, S, C = O or CH 2 ;
E is S or O;
m represents an integer from 0 to 4;
p is an integer from 0 to 4;
q represents an integer from 0 to 4; and
a double line consisting of dashed and solid lines means a single or double bond.
где R2 представляет водород, алкильную группу, имеющую от 1 до 6 углеродных атомов, аминогруппу, имеющую формулу -NR6R7, в которой каждый из R6 и R7 независимо представляет водород, алкил с 1-6 углеродными атомами, фенил, пиридил, пиримидил или бензоил, или фенильную группу, нафтильную группу, циклоалкильную группу, имеющую от 3 до 8 углеродных атомов, или 5-8-членную гетероциклическую группу, содержащую в качестве кольцевых атомов 1-2 атома азота, кислорода или серы и остальные - атомы углерода, каждая из которых может иметь в качестве заместителя алкил с 1-6 углеродными атомами, алкокси с 1-6 углеродными атомами, галоген, гидроксил, галогеналкил с 1-6 углеродными атомами, галогеналкокси с 1-6 углеродными атомами, нитро, амино, фенил, тиенил, фурил, тиазолил или пиридил;
Х представляет O, S, C=O или CH2;
n представляет целое число от 0 до 4; и
двойная линия, состоящая из пунктирной и сплошной линий, означает одинарную или двойную связь.2. Derived quinoline according to claim 1, having the formula II
where R 2 represents hydrogen, an alkyl group having from 1 to 6 carbon atoms, an amino group having the formula —NR 6 R 7 , in which each of R 6 and R 7 independently represents hydrogen, alkyl with 1-6 carbon atoms, phenyl, a pyridyl, pyrimidyl or benzoyl, or a phenyl group, a naphthyl group, a cycloalkyl group having from 3 to 8 carbon atoms, or a 5-8-membered heterocyclic group containing 1-2 nitrogen, oxygen or sulfur atoms as ring atoms and the rest - carbon atoms, each of which may have a substituent alk sludge with 1-6 carbon atoms, alkoxy with 1-6 carbon atoms, halogen, hydroxyl, haloalkyl with 1-6 carbon atoms, halogenoalkoxy with 1-6 carbon atoms, nitro, amino, phenyl, thienyl, furyl, thiazolyl or pyridyl;
X represents O, S, C = O or CH 2 ;
n represents an integer from 0 to 4; and
a double line consisting of dashed and solid lines means a single or double bond.
где R3 представляет фенильную группу, оксазолильную группу или пиридильную группу, каждая из которых может иметь в качестве заместителя алкил с 1-6 углеродными атомами, алкокси с 1-6 углеродными атомами, галоген, гидроксил, галогеналкил с 1-6 углеродными атомами, галогеналкокси с 1-6 углеродными атомами, нитро, амино, фенил, тиенил, фурил, тиазолил или пиридил;
k представляет целое число от 0 до 4.3. Derived quinoline according to claim 1, having the formula III
where R 3 represents a phenyl group, an oxazolyl group or a pyridyl group, each of which may have, as a substituent, alkyl with 1-6 carbon atoms, alkoxy with 1-6 carbon atoms, halogen, hydroxyl, haloalkyl with 1-6 carbon atoms, halogenoalkoxy with 1-6 carbon atoms, nitro, amino, phenyl, thienyl, furyl, thiazolyl or pyridyl;
k is an integer from 0 to 4.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6-281301 | 1994-10-20 | ||
JP28130194 | 1994-10-20 | ||
JP7-218056 | 1995-08-03 | ||
JP21805695 | 1995-08-03 | ||
PCT/JP1995/002167 WO1996012719A1 (en) | 1994-10-20 | 1995-10-20 | Quinoline derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
RU97107992A true RU97107992A (en) | 1999-05-10 |
RU2137770C1 RU2137770C1 (en) | 1999-09-20 |
Family
ID=26522365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU97107992/04A RU2137770C1 (en) | 1994-10-20 | 1995-10-20 | Quinoline derivatives |
Country Status (10)
Country | Link |
---|---|
US (1) | US5693651A (en) |
EP (1) | EP0787725B1 (en) |
KR (1) | KR100356551B1 (en) |
CN (1) | CN1071333C (en) |
AT (1) | ATE238297T1 (en) |
AU (1) | AU712802B2 (en) |
CA (1) | CA2201113A1 (en) |
DE (1) | DE69530501D1 (en) |
RU (1) | RU2137770C1 (en) |
WO (1) | WO1996012719A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0974348B1 (en) * | 1996-11-08 | 2008-07-02 | Nippon Chemiphar Co., Ltd. | Visceral fat lowering agent |
WO2000073273A1 (en) * | 1999-05-28 | 2000-12-07 | Nippon Chemiphar Co., Ltd. | Process for the preparation of 2-halo-3-(3-quinolyl)propionic acid derivatives |
DE60123665T2 (en) * | 2000-12-26 | 2007-08-16 | Sankyo Co., Ltd. | MEDICAL COMPOSITIONS WITH DIURETIC AND INSULIN RESISTANCE TO IMPROVE MEDIUM |
US7015345B2 (en) * | 2002-02-21 | 2006-03-21 | Asahi Kasei Pharma Corporation | Propionic acid derivatives |
US20050119314A1 (en) * | 2002-04-05 | 2005-06-02 | Sankyo Company, Limited | Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent |
US7232828B2 (en) | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
PA8594401A1 (en) * | 2003-02-21 | 2004-09-16 | Pfizer | CARBOXILIC ACIDS OF HETEROARILO CONDENSED AS A PPAR AGONIST |
WO2008020302A2 (en) * | 2006-08-17 | 2008-02-21 | Pfizer Products Inc. | Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors |
JP5162598B2 (en) * | 2006-11-30 | 2013-03-13 | ダウ アグロサイエンシィズ エルエルシー | Process for producing 2-substituted-5- (1-alkylthio) alkylpyrimidine |
EP2516425B1 (en) | 2009-12-23 | 2015-09-02 | Jasco Pharmaceuticals LLC | Aminopyrimidine kinase inhibitors |
WO2012145617A2 (en) * | 2011-04-22 | 2012-10-26 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
CN104011046B (en) | 2011-11-04 | 2017-05-03 | 嘉世高制药公司 | Aminopyrimidine kinase inhibitors |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR240698A1 (en) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Process for the preparation of 5-(4-(2-(5-ethyl-2-pyridil)-ethoxy)benzyl)-2,4-thiazolodinedione and their salts |
ZA936492B (en) * | 1992-09-10 | 1995-03-02 | Lilly Co Eli | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease. |
FR2696743B1 (en) * | 1992-10-12 | 1994-12-23 | Adir | New thiazolidine dione compounds, process for their preparation and pharmaceutical compositions containing them. |
-
1995
- 1995-10-20 AU AU37098/95A patent/AU712802B2/en not_active Ceased
- 1995-10-20 DE DE69530501T patent/DE69530501D1/en not_active Expired - Lifetime
- 1995-10-20 KR KR1019970702575A patent/KR100356551B1/en not_active IP Right Cessation
- 1995-10-20 CN CN95196871A patent/CN1071333C/en not_active Expired - Fee Related
- 1995-10-20 EP EP95934864A patent/EP0787725B1/en not_active Expired - Lifetime
- 1995-10-20 RU RU97107992/04A patent/RU2137770C1/en not_active IP Right Cessation
- 1995-10-20 WO PCT/JP1995/002167 patent/WO1996012719A1/en active IP Right Grant
- 1995-10-20 AT AT95934864T patent/ATE238297T1/en not_active IP Right Cessation
- 1995-10-20 CA CA002201113A patent/CA2201113A1/en not_active Abandoned
- 1995-10-20 US US08/809,592 patent/US5693651A/en not_active Expired - Fee Related
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