RU97106754A - SEPARATION OF MAGNETIC MICROPARTICLES WITH PRELIMINARY CONCENTRATION - Google Patents

SEPARATION OF MAGNETIC MICROPARTICLES WITH PRELIMINARY CONCENTRATION

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Publication number
RU97106754A
RU97106754A RU97106754/03A RU97106754A RU97106754A RU 97106754 A RU97106754 A RU 97106754A RU 97106754/03 A RU97106754/03 A RU 97106754/03A RU 97106754 A RU97106754 A RU 97106754A RU 97106754 A RU97106754 A RU 97106754A
Authority
RU
Russia
Prior art keywords
particles
separation
magnetic
concentration
vessel
Prior art date
Application number
RU97106754/03A
Other languages
Russian (ru)
Other versions
RU2142633C1 (en
Inventor
Юкка Туунанен
Original Assignee
Лабсистемз Ой
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FI944939A external-priority patent/FI944939A0/en
Application filed by Лабсистемз Ой filed Critical Лабсистемз Ой
Publication of RU97106754A publication Critical patent/RU97106754A/en
Application granted granted Critical
Publication of RU2142633C1 publication Critical patent/RU2142633C1/en

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Claims (12)

1. Способ отделения магнитных частиц от смеси в сосуде, отличающийся тем, что сначала осуществляют концентрирование частиц на стенке сосуда и собирают их из этой зоны с использованием магнитного средства для отделения, на котором удерживаются частицы, после чего частицы удаляют со средства для отделения, снимая воздействие магнитного поля, создаваемого средством для отделения.1. A method of separating magnetic particles from a mixture in a vessel, characterized in that the particles are first concentrated on the vessel wall and collected from this zone using a magnetic separation means on which particles are held, after which the particles are removed from the separation means by removing exposure to a magnetic field generated by the separation means. 2. Способ по п. 1, отличающийся тем, что концентрирование частиц осуществляют с использованием магнитного поля, гравитации или центрифугирования. 2. The method according to p. 1, characterized in that the concentration of particles is carried out using a magnetic field, gravity or centrifugation. 3. Способ по п. 2, отличающийся тем, что концентрирование частиц осуществляют с использованием магнитного поля. 3. The method according to p. 2, characterized in that the concentration of particles is carried out using a magnetic field. 4. Способ по любому из пп. 1-3, отличающийся тем, что концентрирование частиц осуществляют на боковой стенке сосуда с образованием вертикальной полоски. 4. The method according to any one of paragraphs. 1-3, characterized in that the concentration of particles is carried out on the side wall of the vessel with the formation of a vertical strip. 5. Способ по любому из пп. 1-3, отличающийся тем, что концентрирование частиц осуществляют с образованием горизонтальной полоски на дне сосуда. 5. The method according to any one of paragraphs. 1-3, characterized in that the concentration of particles is carried out with the formation of a horizontal strip at the bottom of the vessel. 6. Способ по пп. 4 или 5, отличающийся тем, что концентрирование частиц осуществляют с образованием полоски на дне канавки. 6. The method according to PP. 4 or 5, characterized in that the concentration of particles is carried out with the formation of strips at the bottom of the groove. 7. Устройство для отделения магнитных частиц от смеси, отличающееся тем, что оно содержит сосуд для смеси, содержащей частицы, средство (11) для концентрирования частиц на стенке сосуда и магнитное средство для отделения частиц, обеспечивающее сбор частиц из этой зоны, при этом средство для отделения снабжено средством для снятия воздействия магнитного поля для удаления частиц от средства для отделения. 7. A device for separating magnetic particles from a mixture, characterized in that it contains a vessel for a mixture containing particles, means (11) for concentrating particles on the vessel wall and a magnetic means for separating particles, providing for the collection of particles from this zone, for separation equipped with a means for removing the effects of a magnetic field to remove particles from the means for separation. 8. Устройство по п. 7, отличающееся тем, что средство для отделения содержит удлиненное тело (1; 1') с верхним концом и нижним концом и магнит (5, 5') у нижнего конца тела. 8. The device according to p. 7, characterized in that the means for separation contains an elongated body (1; 1 ') with an upper end and a lower end and a magnet (5, 5') at the lower end of the body. 9. Устройство по п. 7 или 8, отличающееся тем, что средство для отделения содержит стержневой магнит, ориентированный в направлении продольной оси тела, при этом отношение длины стержневого магнита к его толщине выбрано не меньшим 2 : 1, предпочтительно не меньшим 3 : 1 и особенно предпочтительно не меньшим 12 : 1. 9. The device according to p. 7 or 8, characterized in that the means for separation contains a bar magnet oriented in the direction of the longitudinal axis of the body, while the ratio of the length of the bar magnet to its thickness is selected not less than 2: 1, preferably not less than 3: 1 and particularly preferably not less than 12: 1. 10. Устройство по п. 9, отличающееся тем, что магнитный стержень (4) содержит магнит (5) на своем нижнем конце и ферромагнитный шток (6), прикрепленный к верхнему концу магнита. 10. The device according to p. 9, characterized in that the magnetic rod (4) contains a magnet (5) at its lower end and a ferromagnetic rod (6) attached to the upper end of the magnet. 11. Устройство по любому из пп. 7-8, отличающееся тем, что средство для отделения содержит защитный корпус (1, 1'). 11. The device according to any one of paragraphs. 7-8, characterized in that the means for separation contains a protective housing (1, 1 '). 12. Устройство по п. 11, отличающееся тем, что средство для отделения содержит стержень (4) с магнитом, подвижным по отношению к корпусу. 12. The device according to p. 11, characterized in that the means for separation includes a rod (4) with a magnet movable with respect to the housing.
RU97106754A 1994-10-20 1995-10-20 Process separating magnetic microparticles with their preliminary concentration and device for its implementation RU2142633C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI944939 1994-10-20
FI944939A FI944939A0 (en) 1994-10-20 1994-10-20 Foerfarande Foer separering av partiklar
PCT/FI1995/000579 WO1996012960A1 (en) 1994-10-20 1995-10-20 Separation of magnetic microparticles involving a pre-concentration step

Publications (2)

Publication Number Publication Date
RU97106754A true RU97106754A (en) 1999-04-10
RU2142633C1 RU2142633C1 (en) 1999-12-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU97106754A RU2142633C1 (en) 1994-10-20 1995-10-20 Process separating magnetic microparticles with their preliminary concentration and device for its implementation

Country Status (8)

Country Link
US (1) US6020211A (en)
EP (1) EP0788603B1 (en)
JP (1) JP3513541B2 (en)
DE (1) DE69525465T2 (en)
FI (1) FI944939A0 (en)
NO (1) NO317664B1 (en)
RU (1) RU2142633C1 (en)
WO (1) WO1996012960A1 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI930440A0 (en) 1993-02-01 1993-02-01 Labsystems Oy BESTAEMNINGSFOERFARANDE
DE69434867T2 (en) 1993-02-01 2007-05-16 Thermo Electron Oy Device for the determination of an analyte in a sample
FI944938A0 (en) * 1994-10-20 1994-10-20 Labsystems Oy Foerflyttningsanordning
FI944937A0 (en) 1994-10-20 1994-10-20 Labsystems Oy Separeringsanordning
FI944940A0 (en) * 1994-10-20 1994-10-20 Labsystems Oy Tvaofasigt separeringsfoerfarande
FI944939A0 (en) * 1994-10-20 1994-10-20 Labsystems Oy Foerfarande Foer separering av partiklar
GB9523045D0 (en) * 1995-11-10 1996-01-10 Genera Tech Ltd Methods of capture and asssy procedures
US6159689A (en) * 1995-11-10 2000-12-12 Genera Technologies Limited Methods of capture and assay procedures
JP2001509891A (en) * 1997-01-30 2001-07-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング Methods for immunological measurement of analytes
JP2005522679A (en) * 2002-04-12 2005-07-28 インストゥルメンテイション ラボラトリー カンパニー Immunoassay probe
FI120863B (en) * 2002-10-18 2010-04-15 Biocontrol Systems Inc Magnetic transfer method and microparticle transfer device
US20040157219A1 (en) * 2003-02-06 2004-08-12 Jianrong Lou Chemical treatment of biological samples for nucleic acid extraction and kits therefor
US7601491B2 (en) * 2003-02-06 2009-10-13 Becton, Dickinson And Company Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
FI20040159A0 (en) 2003-10-20 2004-02-02 Bio Mobile Oy Magnetic transfer method, microparticle transfer device, and reaction unit
WO2005065267A2 (en) * 2003-12-24 2005-07-21 Massachusetts Institute Of Technology Magnetophoretic cell clarification
US20050239091A1 (en) * 2004-04-23 2005-10-27 Collis Matthew P Extraction of nucleic acids using small diameter magnetically-responsive particles
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
US20060024776A1 (en) * 2004-08-02 2006-02-02 Mcmillian Ray Magnetic particle capture of whole intact organisms from clinical samples
AU2005271688B2 (en) * 2004-08-03 2011-10-06 Becton, Dickinson And Company Use of magnetic material to direct isolation of compounds and fractionation of multipart samples
WO2006017427A1 (en) * 2004-08-03 2006-02-16 Becton, Dickinson And Company Use of magnetic material to fractionate samples
US7781228B2 (en) 2005-04-07 2010-08-24 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
FI20051248L (en) * 2005-12-02 2007-06-03 Bio Nobile Oy Enrichment unit and enrichment method for biological components
US20070166730A1 (en) 2006-01-19 2007-07-19 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
WO2008075501A1 (en) 2006-12-19 2008-06-26 Konica Minolta Medical & Graphic, Inc. Rotary extraction container, method of identifying cell species and method of detecting gene using the same, and automatic nucleic acid extractor
DK2171098T3 (en) * 2007-06-29 2018-05-22 Becton Dickinson Co PROCEDURES FOR EXTRACTION AND CLEANING COMPONENTS IN BIOLOGICAL SAMPLES
DE102007045474A1 (en) * 2007-09-21 2009-04-02 Qiagen Gmbh Apparatus and method for treating liquids with magnetic particles
US8222048B2 (en) 2007-11-05 2012-07-17 Abbott Laboratories Automated analyzer for clinical laboratory
DE102009001864A1 (en) * 2009-03-25 2010-09-30 Qiagen Gmbh Overlay for particle separation
US20100297778A1 (en) * 2009-05-20 2010-11-25 Abbott Laboratories Conjugate Having Cleavable Linking Agent
CA3155334A1 (en) 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
FI20115175A0 (en) * 2011-02-23 2011-02-23 Helsinki Thermo Fisher Scient Oy Particle processing
EP2736644B1 (en) 2011-07-29 2020-12-02 Corning Incorporated Magnetic separation device and methods
US9887144B2 (en) * 2011-09-08 2018-02-06 Taiwan Semiconductor Manufacturing Company, Ltd. Ring structure for chip packaging
RU2528885C2 (en) * 2011-10-04 2014-09-20 Общество с ограниченной ответственностью "Инноград Пущино" Method for detecting analyte from particle solution and device for implementing it
US9562271B2 (en) 2012-04-20 2017-02-07 T2 Biosystems, Inc. Compositions and methods for detection of Candida species
US9199870B2 (en) 2012-05-22 2015-12-01 Corning Incorporated Electrostatic method and apparatus to form low-particulate defect thin glass sheets
JP7523776B2 (en) 2016-01-21 2024-07-29 ティー2 バイオシステムズ,インコーポレーテッド NMR method and system for rapid detection of bacteria
RU2643385C1 (en) * 2016-11-11 2018-02-01 Общество с ограниченной ответственностью "ДРД" Device for separation of magnetic particles from reaction fluids

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2471764A (en) * 1946-01-31 1949-05-31 Carl H Miller Magnetic hand pickup tool
US3826619A (en) * 1971-12-21 1974-07-30 Abbott Lab Test apparatus for direct radioimmuno-assay for antigens and their antibodies
BE791340A (en) * 1972-01-06 1973-03-01 Becton Dickinson Co NEW METHOD AND APPARATUS FOR TAKING A CULTURE AND IDENTIFYING MICRO-ORGANISMS OF MOODS
US3985649A (en) * 1974-11-25 1976-10-12 Eddelman Roy T Ferromagnetic separation process and material
US3970518A (en) * 1975-07-01 1976-07-20 General Electric Company Magnetic separation of biological particles
US4018886A (en) * 1975-07-01 1977-04-19 General Electric Company Diagnostic method and device employing protein-coated magnetic particles
US4272510A (en) * 1976-04-26 1981-06-09 Smith Kendall O Magnetic attraction transfer process for use in solid phase radioimmunoassays and in other assay methods
US4200613A (en) * 1977-06-03 1980-04-29 Ramco Laboratories Inc. Radioimmunoassay apparatus
GB1584129A (en) * 1977-06-10 1981-02-04 Nayak P Method and apparatus for performing in vitro clinical diagnostic tests using a solid phase assay system
US4115535A (en) * 1977-06-22 1978-09-19 General Electric Company Diagnostic method employing a mixture of normally separable protein-coated particles
US4378344A (en) * 1979-09-28 1983-03-29 Ventrex Laboratories, Inc. Method and apparatus for performing multiple, simultaneous in vitro diagnostic tests using a solid phase system
EP0030086B2 (en) * 1979-11-13 1990-03-14 TECHNICON INSTRUMENTS CORPORATION (a New York corporation) Test-tube assembly, kit for making it and method of manual immunoassay
GB2107053A (en) * 1980-06-20 1983-04-20 Unilever Plc Processes and apparatus for carrying out specific binding assays
JPS585656A (en) * 1981-07-01 1983-01-13 Olympus Optical Co Ltd Deciding method for particle agglomeration
JPS585657A (en) * 1981-07-01 1983-01-13 Toyo Jozo Co Ltd Immunity measuring element and measuring method employing said element
JPS585658A (en) * 1981-07-02 1983-01-13 Japan Synthetic Rubber Co Ltd Carrier for immunity serological inspecting reagent
GB2147698B (en) * 1981-11-17 1986-05-08 Unilever Plc Test apparatus for immunoassay
IL73187A0 (en) * 1983-10-11 1985-01-31 Lilly Co Eli Purification of esters of alkanoic acids
FR2554016B1 (en) * 1983-10-27 1986-08-08 Pasteur Institut IMPROVEMENTS IN MAGNETIC MEANS FOR REMOVING MAGNETIC GEL BALLS FROM A DOSING FLUID
FI842992A0 (en) * 1984-07-26 1984-07-26 Labsystems Oy IMMUNOLOGISKT DEFINITIONSFOERFARANDE.
FR2572178B1 (en) * 1984-10-23 1988-10-28 Pasteur Institut NOVEL MAGNETIC DEVICE FOR REMOVING MAGNETIC GEL BALLS FROM AN ANALYZED MEDIUM AND TRANSFERRING THESE TO AN IMMUNOENZYMATIC ASSAY MEDIUM
US4839276A (en) * 1984-12-05 1989-06-13 Technicon Instruments Corporation Interference - resistant liposome specific binding assay
FI851702A0 (en) * 1985-04-29 1985-04-29 Labsystems Oy FOERFARANDE OCH ANORDNING FOER UTFOERING IMMUNOBESTAEMNINGAR.
SE8601143L (en) * 1986-03-12 1987-09-13 Carbematrix Ab SET AND DEVICE FOR COLLECTION AND DISTRIBUTION OF FERROMAGNETIC PARTICLES IN A FLUID MEDIUM
JPS635263A (en) * 1986-06-24 1988-01-11 Yasunobu Tsukioka Examination of blood
JPS635265A (en) * 1986-06-25 1988-01-11 Toshiba Corp Method for immunoassay
JPS635266A (en) * 1986-06-25 1988-01-11 Toshiba Corp Analyser
US4891321A (en) * 1987-10-21 1990-01-02 Hubscher Thomas T Apparatus for performing determinations of immune reactants in biological fluids
EP0317286B1 (en) * 1987-11-16 1994-07-13 Amoco Corporation Magnetic separation device and methods for use in heterogeneous assays
US4895650A (en) * 1988-02-25 1990-01-23 Gen-Probe Incorporated Magnetic separation rack for diagnostic assays
EP0351857B1 (en) * 1988-07-20 1994-11-30 Olympus Optical Co., Ltd. Immunoassay method using magnetic marker particles
US5147529A (en) * 1988-08-10 1992-09-15 E. I. Du Pont De Nemours And Company Method for automatically processing magnetic solid phase reagents
EP0418026B1 (en) * 1989-09-13 1994-11-30 Kabushiki Kaisha Tiyoda Seisakusho Apparatus for pretreating cells for flow cytometry
JPH0477225A (en) * 1990-07-18 1992-03-11 Nissei Plastics Ind Co Injection molder
US5200084A (en) * 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
EP0479448A3 (en) * 1990-10-02 1992-12-23 Beckman Instruments, Inc. Magnetic separation device
US5466574A (en) * 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means
JPH0792459B2 (en) * 1991-06-18 1995-10-09 オリンパス光学工業株式会社 Immunological test method
FR2679660B1 (en) * 1991-07-22 1993-11-12 Pasteur Diagnostics METHOD AND MAGNETIC DEVICE FOR IMMUNOLOGICAL ANALYSIS ON A SOLID PHASE.
FI922687A0 (en) * 1992-06-10 1992-06-10 Labsystems Oy AVLAEGSNINGSANORDNING.
FI930440A0 (en) * 1993-02-01 1993-02-01 Labsystems Oy BESTAEMNINGSFOERFARANDE
FI932866A0 (en) * 1993-06-21 1993-06-21 Labsystems Oy Separeringsfoerfarande
DE69434867T2 (en) * 1993-02-01 2007-05-16 Thermo Electron Oy Device for the determination of an analyte in a sample
FI944939A0 (en) * 1994-10-20 1994-10-20 Labsystems Oy Foerfarande Foer separering av partiklar
FI944938A0 (en) * 1994-10-20 1994-10-20 Labsystems Oy Foerflyttningsanordning
FI944940A0 (en) * 1994-10-20 1994-10-20 Labsystems Oy Tvaofasigt separeringsfoerfarande
FI944937A0 (en) * 1994-10-20 1994-10-20 Labsystems Oy Separeringsanordning

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