RU97102763A - METHOD FOR PARTICIPATION OF MICROORGANISMS - Google Patents

METHOD FOR PARTICIPATION OF MICROORGANISMS

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Publication number
RU97102763A
RU97102763A RU97102763/13A RU97102763A RU97102763A RU 97102763 A RU97102763 A RU 97102763A RU 97102763/13 A RU97102763/13 A RU 97102763/13A RU 97102763 A RU97102763 A RU 97102763A RU 97102763 A RU97102763 A RU 97102763A
Authority
RU
Russia
Prior art keywords
microbacterium
nutrient medium
hydrogen
medium further
atcc
Prior art date
Application number
RU97102763/13A
Other languages
Russian (ru)
Other versions
RU2188867C2 (en
Inventor
М.Шартрэн Мишель
Том Чен Ших-Шунг
М.Гэррити Джордж
Хеймбуш Брайен
Роберж Кристофер
Шафи Али
Original Assignee
Мерк энд Ко., Инк,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/277,728 external-priority patent/US5491077A/en
Application filed by Мерк энд Ко., Инк, filed Critical Мерк энд Ко., Инк,
Publication of RU97102763A publication Critical patent/RU97102763A/en
Application granted granted Critical
Publication of RU2188867C2 publication Critical patent/RU2188867C2/en

Links

Claims (1)

1. Способ получения соединения формулы IV
Figure 00000001

отличающийся тем, что осуществляют реакцию соединений формулы IV
Figure 00000002

с Microbacterium MB 5614, депонированного как ATCC 55557, или с его мутантом или его вариантом;
где A представляет собой -CH=CH-S- или -СН=СН-СН=СН-R1 и R2, независимо, представляют собой водород или галоген;
R3 представляет собой CO2R6, COR6 или C(R7)2-O-R8;
R6 представляет собой водород или низший алкил;
R7 представляет собой низший алкил; и
R8 представляет собой водород или группу, защищающую гидроксильную группу,
2. Способ по п.1, отличающийся тем, что А представляет собой -СН=СН-СН= СН-; один из R1 и R2 представляет собой водород, а другой представляет собой галоген, и R представляет собой CO2R6,
3. Способ по п.1, отличающийся тем, что А представляет собой -СН=СН-СН= СН-; один из R и R представляет собой водород, а другой представляет собой хлор, и R представляет собой СО2СН3.1. The method of obtaining the compounds of formula IV
Figure 00000001

characterized in that the reaction of compounds of formula IV
Figure 00000002

with Microbacterium MB 5614 deposited as ATCC 55557, or with its mutant or variant thereof;
where A represents —CH = CH — S— or —CH = CH — CH═CH — R 1 and R 2 independently represent hydrogen or halogen;
R 3 represents CO 2 R 6 , COR 6 or C (R 7 ) 2 —OR 8 ;
R 6 represents hydrogen or lower alkyl;
R 7 represents lower alkyl; and
R 8 represents hydrogen or a hydroxyl protecting group,
2. The method according to claim 1, characterized in that A represents —CH = CH — CH = CH—; one of R 1 and R 2 represents hydrogen, and the other represents halogen, and R represents CO 2 R 6 ,
3. The method according to claim 1, characterized in that A represents —CH = CH — CH = CH—; one of R and R represents hydrogen, and the other represents chlorine, and R represents CO 2 CH 3 . 4. Способ по п.1, отличающийся тем, что упомянуты Microbacterium культивируют в водной питательной среде, содержащей способные к ассимилляции источники углерода и азота. 4. The method according to claim 1, characterized in that said Microbacterium is cultured in an aqueous nutrient medium containing assimilative sources of carbon and nitrogen. 5. Способ по п.1, отличающийся тем, что упомянутый Microbacterium находится в состоянии покоя. 5. The method according to claim 1, characterized in that the said Microbacterium is at rest. 6. Способ по п.4, отличающийся тем, что упомянутая питательная среда дополнительно содержит FeCl3.6. The method according to claim 4, characterized in that the said nutrient medium further comprises FeCl 3 . 7. Способ по п.4, отличающийся тем, что упомянутая питательная среда дополнительно содержит мононатрийглутамат. 7. The method according to claim 4, characterized in that the said nutrient medium further comprises monosodium glutamate. 8. Способ по п.4, отличающийся тем, что упомянутая питательная среда дополнительно содержит FeCl3 и мононатрийглутамат.8. The method according to claim 4, characterized in that the said nutrient medium further comprises FeCl 3 and monosodium glutamate. 9. Биологически чистая культура Microbacterium MB 5614, депонированная как ATCC 55557, или его мутанта или его варианта. 9. A biologically pure culture of Microbacterium MB 5614 deposited as ATCC 55557, or a mutant or variant thereof.
RU97102763/13A 1994-07-20 1995-07-14 Bacterial method of chiralic derivatives of benzyl alcohol preparing RU2188867C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US227728 1988-08-03
US277,728 1994-07-20
US08/277,728 US5491077A (en) 1994-07-20 1994-07-20 Microbial method

Publications (2)

Publication Number Publication Date
RU97102763A true RU97102763A (en) 1999-06-27
RU2188867C2 RU2188867C2 (en) 2002-09-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU97102763/13A RU2188867C2 (en) 1994-07-20 1995-07-14 Bacterial method of chiralic derivatives of benzyl alcohol preparing

Country Status (11)

Country Link
US (1) US5491077A (en)
CN (1) CN1078249C (en)
AU (1) AU3582595A (en)
BR (1) BR9508320A (en)
CZ (1) CZ16997A3 (en)
FI (1) FI970183A0 (en)
RO (1) RO119235B1 (en)
RU (1) RU2188867C2 (en)
SK (1) SK282257B6 (en)
UA (1) UA47410C2 (en)
WO (1) WO1996002657A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534422A (en) * 1995-05-19 1996-07-09 Merck & Co., Inc. Bioconversion of beta keto-ester to (R) hydroxyester
AR007739A1 (en) * 1996-07-22 1999-11-10 Merck & Co Inc A PROCESS FOR THE PREPARATION OF N- (R) - (2-HYDROXY-2-PIRIDINE-3-IL-ETIL) -2- (4-NITRO-PHENYL) -ACETAMIDE
US5846791A (en) * 1996-07-22 1998-12-08 Merck & Co., Inc. N-(R)-(2-hydroxy-2-pyridine-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide
US6898164B2 (en) * 2001-01-25 2005-05-24 Dphi Acquisitions, Inc. Close tracking algorithm in a digital tracking servo system
JP2009526047A (en) * 2006-02-09 2009-07-16 テバ ファーマシューティカル インダストリーズ リミティド Stable pharmaceutical formulation of Montelukast sodium
CN101528917B (en) * 2006-10-02 2015-07-29 科德克希思公司 The Statins pure for the preparation of stereoisomerism and the composition of synthetic intermediate thereof and method
KR101502634B1 (en) * 2007-02-08 2015-03-16 코덱시스, 인코포레이티드 Ketoreductases and uses thereof
US7977078B2 (en) 2007-08-24 2011-07-12 Codexis, Inc. Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
EP2198018B1 (en) 2007-09-13 2013-11-20 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
KR20100061571A (en) * 2007-09-28 2010-06-07 코덱시스, 인코포레이티드 Ketoreductase polypeptides and uses thereof
JP5646328B2 (en) 2007-10-01 2014-12-24 コデクシス， インコーポレイテッド Ketreductase polypeptide for the production of azetidinone
SI2329013T1 (en) * 2008-08-27 2016-03-31 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010025287A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8273554B2 (en) 2008-08-29 2012-09-25 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
EP2467473B1 (en) 2009-08-19 2016-03-23 Codexis, Inc. Ketoreductase polypeptides for the preparation of phenylephrine
CN101899406B (en) * 2010-04-27 2012-02-22 北京大学 Bacterial strain for removing polycyclic aromatic hydrocarbons and/or degrading polycyclic aromatic hydrocarbons and application thereof
EP2566497B1 (en) 2010-05-04 2015-07-29 Codexis, Inc. Biocatalysts for ezetimibe synthesis
US10405554B2 (en) 2011-07-25 2019-09-10 Monsanto Technology Llc Compositions and methods for controlling head blight disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943528A (en) * 1988-11-22 1990-07-24 Nitto Chemical Industry Co., Ltd. Process for the production of optically active (R)-(-)-3-halo-1,2-propanediol
US5270324A (en) * 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
CA2111372C (en) * 1992-12-22 2007-01-16 Robert N. Young Diaryl 5,6-fusedheterocyclic acids as leukotriene antagonists

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