RU97102352A - AGENT STIMULATING SOLID FABRIC - Google Patents

AGENT STIMULATING SOLID FABRIC

Info

Publication number
RU97102352A
RU97102352A RU97102352/14A RU97102352A RU97102352A RU 97102352 A RU97102352 A RU 97102352A RU 97102352/14 A RU97102352/14 A RU 97102352/14A RU 97102352 A RU97102352 A RU 97102352A RU 97102352 A RU97102352 A RU 97102352A
Authority
RU
Russia
Prior art keywords
agent
polysaccharide
chitosan
use according
hard tissue
Prior art date
Application number
RU97102352/14A
Other languages
Russian (ru)
Other versions
RU2153877C2 (en
Inventor
Ханссон Ханс-Арне
Йоханссон-Руден Гунилла
Ларм Олле
Original Assignee
Астра Актиеболаг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9402528A external-priority patent/SE9402528D0/en
Application filed by Астра Актиеболаг filed Critical Астра Актиеболаг
Publication of RU97102352A publication Critical patent/RU97102352A/en
Application granted granted Critical
Publication of RU2153877C2 publication Critical patent/RU2153877C2/en

Links

Claims (20)

1. Применение хитозана и фиксированного на нем полисахарида, выбранного из гепарина, гепарансульфата, хондроитинсульфатов и декстрансульфата, для производства агента, способного обеспечить стимулированную регенерацию твердой ткани.1. The use of chitosan and a polysaccharide fixed on it, selected from heparin, heparan sulfate, chondroitin sulfates and dextransulfate, for the manufacture of an agent capable of providing stimulated regeneration of solid tissue. 2. Применение по п. 1, отличающееся тем, что стимулированная регенерация твердой ткани создается в связи с имплантатами в твердую ткань, такую как костная ткань. 2. The use according to claim 1, characterized in that the stimulated regeneration of hard tissue is created in connection with implants in hard tissue, such as bone tissue. 3. Применение по п. 1 или 2, отличающееся тем, что полисахарид фиксируется на хитозане посредством ионных связей. 3. The use according to claim 1 or 2, characterized in that the polysaccharide is fixed on chitosan through ionic bonds. 4. Применение по п. 1 или 2, отличающееся тем, что полисахарид фиксируется на хитозане посредством ковалентных связей. 4. The use according to claim 1 or 2, characterized in that the polysaccharide is fixed on chitosan through covalent bonds. 5. Применение по любому из предыдущих пп. 1 - 4, отличающееся тем, что полисахаридом является гепарид или гепарансульфат. 5. The use according to any one of the preceding claims. 1 to 4, characterized in that the polysaccharide is heparide or heparan sulfate. 6. Применение по любому из предыдущих пп. 1 - 5, отличающееся тем, что агент находится в форме порошка или раствора. 6. The use according to any one of the preceding claims. 1 to 5, characterized in that the agent is in the form of a powder or solution. 7. Применение по любому из пп. 1 - 5, отличающееся тем, что агент находится в форме геля. 7. The use according to any one of paragraphs. 1 to 5, characterized in that the agent is in the form of a gel. 8. Применение по любому из пп. 1 - 5, отличающееся тем, что агент находится в форме гранул. 8. The use according to any one of paragraphs. 1 to 5, characterized in that the agent is in the form of granules. 9. Применение по любому из предыдущих пп. 1 - 8, отличающееся тем, что хитозан имеет степень N-ацетилирования не более приблизительно 90% и, предпочтительнее, не более приблизительно 50%. 9. The use according to any one of the preceding claims. 1 to 8, characterized in that the chitosan has a degree of N-acetylation of not more than approximately 90% and, more preferably, not more than approximately 50%. 10. Применение по п. 9, отличающееся тем, что хитозан имеет степень N-ацетилирования менее приблизительно 25%. 10. The use of claim 9, wherein the chitosan has an N-acetylation degree of less than about 25%. 11. Применение по любому из пп. 2 - 10, отличающееся тем, что имплантат включает в себя титан. 11. The use according to any one of paragraphs. 2 to 10, characterized in that the implant includes titanium. 12. Способ стимуляции и/или ускорения регенерации твердой ткани, который характеризуется нанесением на соответствующий участок агента, включающего хитозан и фиксированный на нем полисахарид, который выбирают из гепарина, гепарансульфата, хондроитинсульфатов и декстрансульфата, в количестве, достаточном для стимуляции. 12. A method of stimulating and / or accelerating the regeneration of hard tissue, which is characterized by applying to an appropriate site an agent including chitosan and a polysaccharide fixed on it, which is selected from heparin, heparan sulfate, chondroitin sulfates and dextransulfate, in an amount sufficient to stimulate. 13. Способ по п. 12, отличающийся тем, что регенерация связана оссеоинтеграцией. 13. The method according to p. 12, characterized in that the regeneration is associated with osseointegration. 14. Способ по п. 13, отличающийся тем, что оссеоинтеграция выполняется в связи с имплантатами в твердую ткань, такую как костная ткань. 14. The method according to p. 13, characterized in that the osseointegration is performed in connection with implants in hard tissue, such as bone tissue. 15. Способ по пп. 12 - 14, отличающийся тем, что указанный агент наносят в форме порошка. 15. The method according to PP. 12 to 14, characterized in that said agent is applied in powder form. 16. Способ по пп. 12 - 14, отличающийся тем, что указанный агент наносят в форме геля. 16. The method according to PP. 12 to 14, characterized in that said agent is applied in gel form. 17. Способ по любому из пп. 12 - 16, отличающийся тем, что полисахарид представляет гепарин или гепарансульфат. 17. The method according to any one of paragraphs. 12 to 16, characterized in that the polysaccharide is heparin or heparan sulfate. 18. Способ по пп. 13, 14 или 17, отличающийся тем, что агент наносят путем погружения той части имплантата, которая предназначена для интегрирования в твердую ткань, в раствор хитозана и полисахарида. 18. The method according to PP. 13, 14 or 17, characterized in that the agent is applied by immersion of that part of the implant, which is intended to be integrated into hard tissue, in a solution of chitosan and polysaccharide. 19. Имплантат, предназначенный для интегрирования в твердую ткань, который характеризуется тем, что по меньшей мере часть имплантата, которая предназначена для интегрирования, покрыта агентом, стимулирующим регенерацию твердой ткани, включающим в себя хитозан и фиксированный на нем полисахарид, который выбирают из гепарина, гепарансульфата, хондроитинсульфатов и декстрансульфата. 19. An implant designed to integrate into hard tissue, which is characterized in that at least a portion of the implant that is intended to integrate is coated with an agent that stimulates the regeneration of hard tissue, including chitosan and a polysaccharide fixed on it, which is selected from heparin, heparan sulfate, chondroitin sulfates and dextransulfate. 20. Имплантат по п. 19, отличающийся тем, что он включает в себя титан. 20. The implant according to claim 19, characterized in that it includes titanium.
RU97102352/14A 1994-07-19 1995-07-13 Agent stimulating regeneration of solid tissue RU2153877C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9402528A SE9402528D0 (en) 1994-07-19 1994-07-19 Hard tissue stimulant with electricity
SE9402528-5 1994-07-19

Publications (2)

Publication Number Publication Date
RU97102352A true RU97102352A (en) 1999-02-27
RU2153877C2 RU2153877C2 (en) 2000-08-10

Family

ID=20394768

Family Applications (1)

Application Number Title Priority Date Filing Date
RU97102352/14A RU2153877C2 (en) 1994-07-19 1995-07-13 Agent stimulating regeneration of solid tissue

Country Status (22)

Country Link
US (1) US5894070A (en)
EP (1) EP0771206B1 (en)
JP (1) JP3492377B2 (en)
KR (1) KR100395724B1 (en)
CN (1) CN1081923C (en)
AT (1) ATE219678T1 (en)
BR (1) BR9508322A (en)
CA (1) CA2194462C (en)
CZ (1) CZ289981B6 (en)
DE (1) DE69527203T2 (en)
DK (1) DK0771206T3 (en)
ES (1) ES2178675T3 (en)
FI (1) FI970202A0 (en)
HU (1) HU220770B1 (en)
IS (1) IS1793B (en)
MX (1) MX9700443A (en)
NO (1) NO310223B1 (en)
NZ (1) NZ290219A (en)
PL (1) PL181764B1 (en)
RU (1) RU2153877C2 (en)
SE (1) SE9402528D0 (en)
WO (1) WO1996002259A1 (en)

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