RU97100167A - METHOD FOR REMOVING WASTE OF OX, ALENDRONATE AND ITS BY-PRODUCTS - Google Patents

METHOD FOR REMOVING WASTE OF OX, ALENDRONATE AND ITS BY-PRODUCTS

Info

Publication number
RU97100167A
RU97100167A RU97100167/04A RU97100167A RU97100167A RU 97100167 A RU97100167 A RU 97100167A RU 97100167/04 A RU97100167/04 A RU 97100167/04A RU 97100167 A RU97100167 A RU 97100167A RU 97100167 A RU97100167 A RU 97100167A
Authority
RU
Russia
Prior art keywords
amino
acid
bisphosphonic acid
salts
phosphorus
Prior art date
Application number
RU97100167/04A
Other languages
Russian (ru)
Other versions
RU2126415C1 (en
Inventor
С.Венкатарамани Эдаманал
Л.Форман Эндрю
Дж.Маглитт Ральф (младший)
Маккини Дональд
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/254,805 external-priority patent/US5449819A/en
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Application granted granted Critical
Publication of RU2126415C1 publication Critical patent/RU2126415C1/en
Publication of RU97100167A publication Critical patent/RU97100167A/en

Links

Claims (10)

1. Способ удаления фосфорсодержащих отходов, включающий следующие стадии: а) контактирование водной среды, содержащей соли омега-амино-(C2-C6)алкилиден-1-гидрокси-1,1-бифосфоновой кислоты, метансульфокислоты, фосфористой кислоты и фосфорной кислоты, с хлоридом кальция в количестве 2-10 вес. ч. хлорида кальция, взятого в виде безводной соли, на 100 об. ч. среды; b) контактирование указанного раствора со стадии (а) с оксидом кальция, взятом в количестве, достаточном, чтобы вызвать осаждение солей, содержащих кальций и фосфор; с) контактирование указанной смеси со стадии (b) с кислотой, чтобы довести рН водной части смеси до примерно 6-8, чтобы вызвать осаждение указанных солей, содержащих кальций и фосфор; d) отделения указанной осажденной смеси солей, содержащих кальций и фосфор, из водной среды.1. A method for removing phosphorus-containing wastes, comprising the following stages: a) contacting an aqueous medium containing salts of omega-amino (C 2 -C 6 ) alkylidene-1-hydroxy-1,1-bisphosphonic acid, methanesulfonic acid, phosphorous acid and phosphoric acid , with calcium chloride in an amount of 2-10 weight. including calcium chloride, taken in the form of an anhydrous salt, per 100 vol. hours of Wednesday; b) contacting said solution from step (a) with calcium oxide, taken in an amount sufficient to cause precipitation of salts containing calcium and phosphorus; c) contacting said mixture from step (b) with an acid to bring the pH of the aqueous portion of the mixture to about 6-8 to precipitate said salts containing calcium and phosphorus; d) separating said precipitated mixture of salts containing calcium and phosphorus from the aqueous medium. 2. Способ по п. 1, в котором указанную омега-амино(C2-C6)алкилиден-1,1-бифосфоновую кислоту выбирают из 4-амино-1-гидроксибутилиден-1,1-бифосфоновой кислоты, 2-амино-1-гидроксиизобутилиден-1,1-бифосфоновой кислоты, 3-амино-1-гидроксипропилиден-1,1-бифосфоновой кислоты, 5-амино-1-гидроксипентилиден-1,1-бифосфоновой кислоты и 6-амино-1-гидроксигексилиден-1,1-бифосфоновой кислоты.2. The method according to claim 1, wherein said omega-amino (C 2 -C 6 ) alkylidene-1,1-bisphosphonic acid is selected from 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid, 2-amino 1-hydroxyisobutylidene-1,1-bisphosphonic acid, 3-amino-1-hydroxypropylidene-1,1-bisphosphonic acid, 5-amino-1-hydroxypentylidene-1,1-bisphosphonic acid and 6-amino-1-hydroxyhexylidene-1 , 1-bisphosphonic acid. 3. Способ по п. 2, в котором указанная омега-амино(C2-C6)алкилиден-1,1-бифосфоновая кислота является 4-амино-1-гидроксибутилиден-1,1-бифосфоновой кислотой.3. The method of claim 2, wherein said omega-amino (C 2 -C 6 ) alkylidene-1,1-bisphosphonic acid is 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid. 4. Способ по п. 1, в котором указанные соли омега-амино(C2-C6)алкилиден-1-гидрокси-1,1-бифосфоновой кислоты, метансульфокислоты, фосфористой и фосфорной кислот являются натриевыми солями.4. The method according to claim 1, wherein said salts of omega-amino (C 2 -C 6 ) alkylidene-1-hydroxy-1,1-bisphosphonic acid, methanesulfonic acid, phosphorous and phosphoric acids are sodium salts. 5. Способ по п. 1, в котором указанный хлорид кальция находится в форме гексагидрата. 5. The method of claim 1, wherein said calcium chloride is in the form of hexahydrate. 6. Способ по п. 1, в котором указанный хлорид кальция на стадии (а) присутствует в количестве 2-7%(вес/об.) маточного раствора. 6. The method of claim 1, wherein said calcium chloride in step (a) is present in an amount of 2-7% (w / v) of the mother liquor. 7. Способ по п. 1, в котором указанный рН на стадии (b) равен примерно 10-12. 7. The method of claim 1, wherein said pH in step (b) is about 10-12. 8. Способ по п. 1, в котором добавляемая на стадии (с) кислота представляет собой соляную кислоту. 8. The method of claim 1, wherein the acid added in step (c) is hydrochloric acid. 9. Осажденная смесь солей, содержащих кальций и фосфор, полученная способом по п. 1. 9. The precipitated mixture of salts containing calcium and phosphorus obtained by the method according to p. 1. 10. Осажденная смесь по п. 9, содержащая алендронат. 10. The precipitated mixture according to claim 9, containing alendronate.
RU97100167/04A 1994-06-06 1995-06-02 Method of removing phosphorus-containing waste resulting from preparation of omega-amino-(c2-c6) alkylidene- 1-hydroxy-1,1-bisphosphonic acid salts, and deposited mixture of calcium-and phosphorus-containing salts RU2126415C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US254,805 1994-06-06
US08/254,805 US5449819A (en) 1994-06-06 1994-06-06 Process for removing waste pox, alendronate and its by products
PCT/US1995/006964 WO1995033755A1 (en) 1994-06-06 1995-06-02 PROCESS FOR REMOVING WASTE POx, ALENDRONATE AND ITS BY-PRODUCTS

Publications (2)

Publication Number Publication Date
RU2126415C1 RU2126415C1 (en) 1999-02-20
RU97100167A true RU97100167A (en) 1999-02-20

Family

ID=22965653

Family Applications (1)

Application Number Title Priority Date Filing Date
RU97100167/04A RU2126415C1 (en) 1994-06-06 1995-06-02 Method of removing phosphorus-containing waste resulting from preparation of omega-amino-(c2-c6) alkylidene- 1-hydroxy-1,1-bisphosphonic acid salts, and deposited mixture of calcium-and phosphorus-containing salts

Country Status (23)

Country Link
US (1) US5449819A (en)
EP (1) EP0765332B1 (en)
AT (1) ATE187730T1 (en)
AU (1) AU686819B2 (en)
BR (1) BR9507932A (en)
CA (1) CA2191772A1 (en)
CZ (1) CZ289545B6 (en)
DE (1) DE69513977T2 (en)
DK (1) DK0765332T3 (en)
ES (1) ES2141942T3 (en)
FI (1) FI964895A0 (en)
GR (1) GR3032591T3 (en)
HR (1) HRP950319B1 (en)
HU (1) HUT76709A (en)
NZ (1) NZ287775A (en)
PT (1) PT765332E (en)
RO (1) RO117614B1 (en)
RU (1) RU2126415C1 (en)
SK (1) SK281649B6 (en)
TW (1) TW299334B (en)
UA (1) UA45972C2 (en)
WO (1) WO1995033755A1 (en)
YU (1) YU36295A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
US6160165A (en) 1998-12-10 2000-12-12 Aesgen, Inc. Method for preparation of disodium pamidronate
US6794536B1 (en) 1998-12-10 2004-09-21 Aesqen, Inc. Method for preparation of disodium pamidronate
CA2372450A1 (en) * 2001-05-10 2001-09-19 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate
JP3857706B2 (en) * 2002-05-17 2006-12-13 テバ ファーマシューティカル インダストリーズ リミティド Use of specific diluents to make bisphosphonic acid
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
US20060134190A1 (en) * 2004-12-16 2006-06-22 Banner Pharmacaps Inc. Formulations of bisphosphonate drugs with improved bioavailability
US8076483B2 (en) * 2006-05-11 2011-12-13 M/S. Ind Swift Laboratories Limited Process for the preparation of pure risedronic acid or salts

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3716484A (en) * 1971-05-10 1973-02-13 Michigan Chem Corp Process for substantial removal of phosphates from wastewaters
US3816306A (en) * 1972-05-19 1974-06-11 C Roy Copper etchant effluent treatment
DE2732777C2 (en) * 1977-07-20 1979-09-13 Benckiser-Knapsack Gmbh, 6802 Ladenburg N-carboxyalkane-aminoalkane-polyphosphonic acids and their alkali metal salts and processes for their preparation
DE2758306C3 (en) * 1977-12-27 1981-05-27 Benckiser-Knapsack Gmbh, 6802 Ladenburg Process for the preparation of N-sulfoalkanaminoalkanephosphonic acids or their alkali salts
JPS5888097A (en) * 1981-11-19 1983-05-26 Ebara Infilco Co Ltd Purification of filthy water such as night soil
IT1201087B (en) * 1982-04-15 1989-01-27 Gentili Ist Spa PHARMACOLOGICALLY ACTIVE BIPPHOSPHONES, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS
US4450047A (en) * 1983-01-28 1984-05-22 Penwalt Corporation Process for recovering anhydrous alkanesulfonic acids by reduced pressure, falling film evaporation
US4761406A (en) * 1985-06-06 1988-08-02 The Procter & Gamble Company Regimen for treating osteoporosis
US4689154A (en) * 1985-11-15 1987-08-25 Occidental Chemical Corporation Process for removing phosphorus from industrial waste water
US4938846A (en) * 1986-12-08 1990-07-03 Atochem, North America, Inc. Preparation of anhydrous alkanesulfonic acid
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5128040A (en) * 1989-08-02 1992-07-07 Polytechnic University Wastewater treatment process
JP2720096B2 (en) * 1990-04-17 1998-02-25 新日本製鐵株式会社 Method for simultaneous removal of BOD, nitrogen compounds and phosphorus compounds in wastewater
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids

Similar Documents

Publication Publication Date Title
LV11471A (en) Contribution to the production of 4-amino-1-hydroxybutylidine-1,1-diphosphorus islands
RU97100167A (en) METHOD FOR REMOVING WASTE OF OX, ALENDRONATE AND ITS BY-PRODUCTS
KR850007062A (en) Method for preparing N, N-diacetic acid amino methylenephosphonic acid
HUP0203078A2 (en) Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
EP0837682B1 (en) Therapeutic use of 1-amino-3-(n,n-dimethylamino)-propyliden-1,1-bisphosphonic acid and its salts
RU97100188A (en) METHOD OF REGENERATION AND RECYCLIZATION OF METHANESULPHONE ACID AND PHOSPHORIC ACID
ES548042A0 (en) A PROCEDURE FOR THE PREPARATION OF VAN-COMICINA HYDROCHLORIDE
RU2126415C1 (en) Method of removing phosphorus-containing waste resulting from preparation of omega-amino-(c2-c6) alkylidene- 1-hydroxy-1,1-bisphosphonic acid salts, and deposited mixture of calcium-and phosphorus-containing salts
KR970703351A (en) Process for removing waste POx, alendronate and its by-products
PT1803727E (en) Improved process for manufacture of 4-amino-hydroxybutylidene-1,1-bisphosphonic acid and its salts
HUT40451A (en) Process for preparing n-/phosphono-methyl/-glycine
AR020313A1 (en) PROCESS TO PREPARE A DIALQUILESTER OF N-PHOSPHONOMETIL-GLICINA
ATE346086T1 (en) METHOD FOR PRODUCING N2-(1(S)-CARBOXY-3-PHENYLPROPYL)-L-LYSYL-L-PROLINE
PL171708B1 (en) Method of obtaining a herbicide not intended for use in agriculture
TH18940A (en) The process for the preparation of an acid (L) or (D) - homoalanin, 4-il (methyl), phosphinic and acid salts by separating the resymate mixture.