RU96114993A - Derivatives of N-substituted 3-azabicyclo [3.2.0] Heptane - Google Patents
Derivatives of N-substituted 3-azabicyclo [3.2.0] HeptaneInfo
- Publication number
- RU96114993A RU96114993A RU96114993/04A RU96114993A RU96114993A RU 96114993 A RU96114993 A RU 96114993A RU 96114993/04 A RU96114993/04 A RU 96114993/04A RU 96114993 A RU96114993 A RU 96114993A RU 96114993 A RU96114993 A RU 96114993A
- Authority
- RU
- Russia
- Prior art keywords
- group
- hydrogen
- substituted
- carbon atoms
- unsubstituted
- Prior art date
Links
- -1 N-substituted 3-azabicyclo [3.2.0] Heptane Chemical class 0.000 title claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000004432 carbon atoms Chemical group C* 0.000 claims 7
- 229910052801 chlorine Chemical group 0.000 claims 5
- 239000000460 chlorine Chemical group 0.000 claims 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 239000011737 fluorine Substances 0.000 claims 5
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical group 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 1
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000004430 oxygen atoms Chemical group O* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Claims (2)
где R1 - фенил или тиенил, незамещенные или моно- или дизамещенные галогеном, алкилом с 1-4 атомами углерода, трифторметилом, гидроксилом, алкокси-группой с 1-4 атомами углерода, амино-группой, монометиламино-группой, диметиламино-группой, циано-группой или нитро-группой,
R2 - водород или фенил, незамещенный или замещенный галогеном, метокси-группой, гидроксилом, амино-группой,
A - водород или группы
где R3 - водород или гидроксил,
R4 - водород или
R3 и R4 вместе обозначают атом кислорода,
R5 - тиенил или нафтил, незамещенные или замещенные фтором или хлором,
R6 - водород или метил,
R7 - фенил, дизамещенный фтором, хлором, гидроксилом, метоксигруппой или монозамещенный амино-группой, алкиламино-группой с 1-4 атомами углерода, диалкиламино-группой с 1-4 атомами углерода в каждой алкильной части, или незамещенные или замещенные фтором, хлором или нитро-группой тиенил, нафтил, бензофурил, бензотиенил, индолил, N-метилиндолил или инденил, циклоалкил с 3-6 атомами углерода.1. Derivatives of N-substituted 3-azabicyclo [3.2.0] heptane of formula (I)
where R 1 is phenyl or thienyl, unsubstituted or mono- or disubstituted with halogen, alkyl with 1-4 carbon atoms, trifluoromethyl, hydroxyl, alkoxy group with 1-4 carbon atoms, amino group, monomethylamino group, dimethylamino group, cyano group or nitro group,
R 2 is hydrogen or phenyl, unsubstituted or substituted by halogen, methoxy, hydroxyl, amino,
A - hydrogen or groups
where R 3 is hydrogen or hydroxyl,
R 4 is hydrogen or
R 3 and R 4 together represent an oxygen atom,
R 5 - thienyl or naphthyl, unsubstituted or substituted by fluorine or chlorine,
R 6 is hydrogen or methyl,
R 7 - phenyl disubstituted with fluorine, chlorine, hydroxyl, methoxy group or monosubstituted with an amino group, an alkylamino group with 1-4 carbon atoms, dialkylamino group with 1-4 carbon atoms in each alkyl part, or unsubstituted or substituted with fluorine, chlorine or a nitro group of thienyl, naphthyl, benzofuryl, benzothienyl, indolyl, N-methylindolyl or indenyl, cycloalkyl with 3-6 carbon atoms.
R9 - водород, метил,
R10 - водород, метил,
R9 и R10 вместе с кольцевым атомом углерода представляют собой спироциклопропановое кольцо,
R11 - фенил или бензил, незамещенные или замещенные фтором, хлором, циано-группа,
n - 1, 2, 3, 4,
и их соли с физиологически переносимыми кислотами.R 8 is hydrogen, fluorine, chlorine, alkyl with 1-4 carbon atoms, methoxy, amino,
R 9 is hydrogen, methyl,
R 10 is hydrogen, methyl,
R 9 and R 10 together with a ring carbon atom represent a spirocyclopropane ring,
R 11 is phenyl or benzyl, unsubstituted or substituted by fluorine, chlorine, cyano group,
n - 1, 2, 3, 4,
and their salts with physiologically tolerated acids.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4341402.8 | 1993-12-04 | ||
| DE4341402A DE4341402A1 (en) | 1993-12-04 | 1993-12-04 | N-substituted azabicycloheptane derivatives, their preparation and use |
| PCT/EP1994/003910 WO1995015312A1 (en) | 1993-12-04 | 1994-11-26 | N-substituted azabicycloheptane derivatives used, for example, as neuroleptics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU96114993A true RU96114993A (en) | 1998-10-20 |
| RU2136678C1 RU2136678C1 (en) | 1999-09-10 |
Family
ID=6504204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU96114993A RU2136678C1 (en) | 1993-12-04 | 1994-11-26 | N-substituted 3-azabicyclo[32,0]heptane derivatives |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5616705A (en) |
| EP (1) | EP0740658B1 (en) |
| JP (1) | JP3883567B2 (en) |
| KR (1) | KR100331407B1 (en) |
| CN (1) | CN1054844C (en) |
| AT (1) | ATE244222T1 (en) |
| AU (1) | AU679812B2 (en) |
| BR (1) | BR9408244A (en) |
| DE (2) | DE4341402A1 (en) |
| ES (1) | ES2202348T3 (en) |
| FI (1) | FI962323A (en) |
| HR (1) | HRP940960A2 (en) |
| HU (1) | HU220070B (en) |
| IL (1) | IL111862A (en) |
| NO (1) | NO306400B1 (en) |
| NZ (1) | NZ276411A (en) |
| PL (1) | PL314840A1 (en) |
| RU (1) | RU2136678C1 (en) |
| TW (1) | TW324007B (en) |
| UA (1) | UA44721C2 (en) |
| WO (1) | WO1995015312A1 (en) |
| ZA (1) | ZA949593B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4427648A1 (en) * | 1994-08-04 | 1996-02-08 | Basf Ag | N-Stubstituted 3-azabicyclo [3,2,0,] heptane derivatives, their preparation and use |
| DE4341402A1 (en) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituted azabicycloheptane derivatives, their preparation and use |
| DE4427647A1 (en) * | 1994-08-04 | 1996-02-08 | Basf Ag | N-substituted azabicycloheptane derivatives, their preparation and use |
| YU2901A (en) | 1998-07-17 | 2004-05-12 | Agouron Pharmaceuticals Inc. | Compounds, compositions and methods for stimulating neuronal growth and elongation |
| DE19836404A1 (en) * | 1998-08-12 | 2000-02-17 | Basf Ag | New benzimidazolonyl-substituted 3-azabicyclo (3.2.0) heptane derivatives, useful e.g. as neuroleptics, antidepressants, hypnotics and sedatives |
| US6458821B1 (en) | 1998-08-12 | 2002-10-01 | Abbott Laboratories | N-substituted azabicycloheptane derivatives, production and use thereof |
| DE19836406A1 (en) * | 1998-08-12 | 2000-02-17 | Basf Ag | New S,S-dioxobenzisothiazolinyl-substituted 3-azabicyclo (3.2.0) heptane derivatives, useful e.g. as neuroleptics, antidepressants, hypnotics and sedatives |
| FR2791345B1 (en) * | 1999-03-26 | 2001-05-04 | Adir | NOVEL BENZO [3,4] CYCLOBUTA [1,2-C] PYRROLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US7135484B2 (en) | 2002-08-14 | 2006-11-14 | Abbott Laboratories | Azabicyclic compounds are central nervous system active agents |
| JP4629576B2 (en) * | 2002-08-14 | 2011-02-09 | アボット・ラボラトリーズ | Azabicyclo compounds as central nervous system active agents |
| ATE423769T1 (en) * | 2002-08-23 | 2009-03-15 | Ranbaxy Lab Ltd | FLUORINE AND SULFONYLAMINO CONTAINING, 3,6-DISUBSTITUTED AZABICYCLO 3.1.0 HEXANE DERIVATIVES AS MUSCARINO RECEPTOR ANTAGONISTS |
| FR2953514B1 (en) * | 2009-12-09 | 2011-12-23 | Servier Lab | NOVEL AZABICYCLO [3.2.0] HEPT-3-YL DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| CN105473554B (en) * | 2013-07-10 | 2019-08-13 | 沃泰克斯药物股份有限公司 | Condensed piperidine amide as ion channel modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4112353A1 (en) * | 1991-04-16 | 1992-10-22 | Basf Ag | 1,3,4-TRISUBSTITUTED PIPERIDINE DERIVATIVES, THEIR PRODUCTION AND USE |
| DE4219973A1 (en) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituted azabicycloheptane derivatives, their preparation and use |
| DE4243287A1 (en) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituted azabicycloheptane derivatives, their preparation and use |
| DE4341402A1 (en) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituted azabicycloheptane derivatives, their preparation and use |
-
1993
- 1993-12-04 DE DE4341402A patent/DE4341402A1/en not_active Withdrawn
-
1994
- 1994-11-26 CN CN94194394A patent/CN1054844C/en not_active Expired - Fee Related
- 1994-11-26 KR KR1019960702910A patent/KR100331407B1/en not_active IP Right Cessation
- 1994-11-26 BR BR9408244A patent/BR9408244A/en not_active Application Discontinuation
- 1994-11-26 US US08/632,398 patent/US5616705A/en not_active Expired - Lifetime
- 1994-11-26 NZ NZ276411A patent/NZ276411A/en unknown
- 1994-11-26 AT AT95901436T patent/ATE244222T1/en not_active IP Right Cessation
- 1994-11-26 JP JP51538095A patent/JP3883567B2/en not_active Expired - Fee Related
- 1994-11-26 HU HU9601511A patent/HU220070B/en not_active IP Right Cessation
- 1994-11-26 DE DE59410304T patent/DE59410304D1/en not_active Expired - Lifetime
- 1994-11-26 RU RU96114993A patent/RU2136678C1/en active
- 1994-11-26 PL PL94314840A patent/PL314840A1/en unknown
- 1994-11-26 AU AU10671/95A patent/AU679812B2/en not_active Ceased
- 1994-11-26 EP EP95901436A patent/EP0740658B1/en not_active Expired - Lifetime
- 1994-11-26 ES ES95901436T patent/ES2202348T3/en not_active Expired - Lifetime
- 1994-11-26 WO PCT/EP1994/003910 patent/WO1995015312A1/en active IP Right Grant
- 1994-11-26 UA UA96072631A patent/UA44721C2/en unknown
- 1994-11-29 HR HRP4341402.8A patent/HRP940960A2/en not_active Application Discontinuation
- 1994-12-02 IL IL11186294A patent/IL111862A/en not_active IP Right Cessation
- 1994-12-02 ZA ZA949593A patent/ZA949593B/en unknown
- 1994-12-05 TW TW083111265A patent/TW324007B/en active
-
1996
- 1996-06-03 NO NO962285A patent/NO306400B1/en not_active IP Right Cessation
- 1996-06-03 FI FI962323A patent/FI962323A/en unknown
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